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RNA Interference pp 225–256Cite as

RNA Silencing in Mammalian Oocytes and Early Embryos

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 320))

Abstract

RNA silencing is a common term for homology-dependent silencing phenomena found in the majority of eukaryotic species. RNA silencing pathways share several conserved components. The common denominator of these pathways is the presence of specific, short (21–25 nt) RNA molecules generated from different double-stranded RNA substrates by a specific RNase III activity. Short RNA molecules serve as a template for sequence-specific effects including transcriptional silencing, mRNA degradation, and inhibition of translation. This review will discuss possible roles of RNA silencing pathways in mouse oocytes and early embryos as well as the use of RNA silencing for experimental inhibition of gene expression in this model system.

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  1. Institute of Molecular Genetics, Czech Academy of Sciences, Videnska 1083, 14220, Prague, Czech Republic

    Petr Svoboda

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  1. Cold Spring Harbor Laboratory, Cold Spring Harbor Fellows Program, Cold Spring Harbor, NY, 11771

    Patrick J. Paddison

  2. Department of Molecular & Experimental Medicine Division of Oncovirology, The Scripps Research Institute, 10550 N. Torrey Pines Road, BCC-239, La Jolla, CA, 92037, USA

    Peter K. Vogt

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Svoboda, P. (2008). RNA Silencing in Mammalian Oocytes and Early Embryos. In: Paddison, P.J., Vogt, P.K. (eds) RNA Interference. Current Topics in Microbiology and Immunology, vol 320. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75157-1_11

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