Abstract
Magnetic particle imaging (MPI) is a quantitative imaging method that uses the nonlinear re-magnetization behavior of ferromagnetic nanoparticles to determine their local concentration. Superparamagnetic iron oxide (SPIO) particles represent such suitable nanoparticles. SPIOs are readily available as clinically approved contrast agents for liver examinations in magnetic resonance imaging (MRI), and usually administered into the bloodstream via intravenous injection. Starting from a brief overview of the history of the discovery and ongoing research on MPI in Sect. 24.2, Sect. 24.3 introduces the technical concepts of MPI. Section 24. 4 will explain how to get to actual images, once data has been acquired. Section 24.5 describes alternative system designs next to traditional, symmetric geometries commonly used for medical imaging devices, and other uses of magnetic particle imaging technology, like spectroscopy. A possible combination of MPI with magnetic resonance tomography (MRT) for hybrid MPI/MRT systems is introduced in Sect.24.5.3. Finally, Sect. 24.6 discusses potential applications for MPI and how it can provide clinical benefits, covering cardiovascular applications in Sect.24.6.1, oncology applications in Sect.24.6.2, cell labeling/tracking in Sect. 24.6.3, and concluding with applications that require new, modified tracer materials in Sect. 24.6.4.
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References
B. Gleich, J. Weizenecker: Tomographic imaging usingthe nonlinear response of magnetic particles, Nature 435, 1214–1217 (2005)
B. Gleich: Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel, German Patent DE-10151778-A1 (2001)
B. Gleich, J. Weizenecker, J. Borgert: Experimental results on fast 2-D-encoded magnetic particle imaging, Phys. Med. Biol. 53, N81–N84 (2008)
J. Weizenecker, B. Gleich, H. Dahnke, J. Rahmer, J. Borgert: Three-dimensional real-time in vivo magnetic particle imaging, Phys. Med. Biol. 54, L1–L10 (2009)
P. Goodwill, G.C. Lee, G. Scott, P. Stang, S. Conolly: Direct imaging of ferumoxides using magnetic particle imaging: Sensitivity and instrument construction, Proc. Intl. Soc. Mag. Reson. Med. (2009)
P. Goodwill, G. Scott, P. Stang, G.C. Lee, D. Morris, S. Conolly: Direct imaging of SPIOs in mice using magnetic particle imaging: Instrument construction and 3-D imaging, Proc. Intl. Soc. Mag. Reson. Med. (2009) p. 596
P. Goodwill, C. Scott, P. Stang, S. Conolly: Narrowband magnetic particle imaging, IEEE Trans. Med. Imaging 28(8), 1231–1237 (2009)
J. Weizenecker, J. Borgert, B. Gleich: A simulation study on the resolution and sensitivity of magnetic particle imaging, Phys. Med. Biol. 52, 6363–6374 (2007)
T. Knopp, S. Biederer, T.F. Sattel, J. Weizenecker, B. Gleich, J. Borgert, T.M. Buzug: Trajectory analysis for magnetic particle imaging, Phys. Med. Biol. 54(2), 385–397 (2009)
J. Weizenecker, B. Gleich, J. Borgert: Magnetic particle imaging using a field free line, J. Phys. D: Appl. Phys. 41, 105009–105012 (2008)
T. Knopp, T.F. Sattel, S. Biederer, T.M. Buzug: Field-free line formation in a magnetic field, J. Phys. A: Math. Theor. 43, 012002 (2010)
T.F. Sattel, S. Biederer, T. Knopp, K. Lüdtke-Buzug, B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug: Single-Sided Coil Configuration for Magnetic Particle Imaging, Springer IFMBE, Vol. 25/VII (Springer, Munich 2009)
S. Biederer, T.F. Sattel, T. Knopp, K. Lüdtke-Buzug, B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug: A spectrometer for magnetic particle imaging, Proc. 4th Eur. Congr. Med. Biomed. Eng., IFMBE Proc., Vol.25 (Springer, Berlin Heidelberg 2008) pp.2313–2316
S. Biederer, T. Knopp, T.F. Sattel, K. Lüdtke-Buzug, B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug: Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging, J. Phys. D: Appl. Phys. 42(20), 205007 (2009)
J.B. Weaver, A.M. Rauwerdink, C.R. Sullivan, I. Baker: Signal dependence on frequency in magnetic particle imaging, Med. Phys. 34(6), 2361 (2007)
J.B. Weaver, A.M. Rauwerdink: An alternative spatial encoding method for magnetic nanoparticle imaging, Med. Phys. 35(6), 2642 (2008)
J.B. Weaver, E.W. Hansen, A.M. Rauwerdink: Estimating temperature from the magnetic nanoparticle magnetization, Med. Phys. 35(6), 2907–2908 (2008)
J.B. Weaver, A.M. Rauwerdink, C.R. Sullivan, I. Baker: Frequency distribution of the nanoparticle magnetization in the presence of a static as well as a harmonic magnetic field, Med. Phys. 35(5), 1988–1995 (2008)
A.M. Rauwerdink, E.W. Hansen, J.B. Weaver: Nanoparticle temperature estimation in combined AC and DC magnetic fields, Phys. Med. Biol. 54, L51–L55 (2009)
J. Moreland, J. Eckstein, Y. Lin, S.-H. Liou, S. Ruggiero: Magnetic particle imaging with a cantilever torque magnetometer, 2007 APS March Meeting, http://meetings.aps.org/Meeting/MAR07/Event/ 62054, 2007
J. Bohnert, B. Gleich, J. Weizenecker, J. Borgert, O. Dössel: Evaluation of induced current densities and SAR in the human body by strong magnetic fields around 100 kHz, IFMBE Proc. (Springer, Berlin Heidelberg 2008) pp. 2532–2535
J. Bohnert, B. Gleich, J. Weizenecker, J. Borgert, O. Dössel: Optimizing coil currents for reduced SAR in magnetic particle imaging, IFMBE Proc. (2009) pp. 249–252
K. Lüdtke-Buzug, S. Biederer, T.F. Sattel, T. Knopp, T.M. Buzug: Particle-Size Distribution of Dextranand Carboxydextan-Coated Superparamagnetic Nanoparticlesfor Magnetic Particle Imaging, World Congress on Medical Physics and Biomedical Engineering, Springer IFMBE, Vol. 25/VIII (Springer, Munich 2009)
K. Lüdtke-Buzug, S. Biederer, T.F. Sattel, T. Knopp, T.M. Buzug: Preparation and characterization of dextran-covered Fe3O4 nanoparticles for magnetic particle imaging, Proc. 4th Eur. Congr. Med. Biomed. Eng., IFMBE Proc., Vol. 22 (Springer, Berlin Heidelberg 2008) pp. 2343–2346
M.R. Ferguson, K. Minard, K.M. Krishnan: Optimization of nanoparticle core size for magnetic particle imaging, J. Magn. Magn. Mater. 10, 1548–1551 (2009)
D.E. Markov, N.P.M. Haex, J. van Zanten, H. Grull, H.M.B. Boeve: Magnetic particle imaging: Quantitative assessment of tracer performance, 7th Int. Conf. on the Scientific and Clinical Applications of Magnetic Carriers (Vancouver 2008)
N.P.M. Haex, J. van Zanten, H. Grull, D.E. Markov, H.M.B. Boeve: Magnetic nanoparticles as imaging agents for magnetic particle imaging, 7th Int. Conf. on the Scientific and Clinical Applications of Magnetic Carriers (Vancouver 2009)
J.W.M. Bulte, B. Gleich, J. Weizenecker, S. Bernard, P. Walczak, D.E. Markov, H.C.J. Aerts, J. Borgert, H. Boeve: Developing Cellular MPI: Initial Experience (ISMRM, Toronto 2008) pp. 201–204
S. Chikazumi, S.H. Charap: Physics of Magnetism (John Wiley & Sons, New York 1964)
Z.-P. Liang, P.C. Lauterbur: Principles of Magnetic Resonance Imaging: A Signal Processing Perspective (Wiley-IEEE Press, New York 1999)
J.B. Johnson: Thermal agitation of electricity in conductors, Phys. Rev. 32, 97–109 (1928)
T.F. Sattel, T. Knopp, S. Biederer, B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug: Single-sided device for magnetic particle imaging, J. Phys. D: Appl. Phys. 42(2), 1–5 (2009)
W. Press, S. Teukolsky, W. Saul, B. Flannery: Numerical Recepies in C: The Art of Scientific Computing (Cambridge Univ. Press, Cambridge, New York 1992)
A. Macovski, S. Conolly: Novel approaches to lowcost MRI, Magn. Reson. Med. 30(2), 221–230 (1993)
R.D. Venook, N.I. Matter, M. Ramachandran, S.E. Ungersma, G.E. Gold, N.J. Giori, A. Macovski, G.C. Scott, S.M. Conolly: Prepolarized magnetic resonance imaging around metal orthopedic implants, Magn. Reson. Med. 56(1), 177–186 (2006)
S.E. Ungersma, N.I. Matter, J.W. Hardy, R.D. Venook, A. Macovski, S.M. Conolly, G.C. Scott: Magnetic resonance imaging with T1 dispersion contrast, Magn. Reson. Med. 55(6), 1362–1371 (2006)
R. Schmitt, S. Froehner, J. Brunn, M. Wagner, H. Brunner, O. Cherevatyy, F. Gietzen, G. Christopoulos, S. Kerber, F. Fellner: Congenital anomalies of the coronary arteries: imaging with contrast-enhanced, multidetector computed tomography, Eur. Radiol. 15(6), 1110–1121 (2005)
M.B. Nienhuis, J.P. Ottervanger, H.J.G. Bilo, B.D. Dikkeschei, F. Zijlstra: Prognostic value of troponin after elective percutaneous coronary intervention: A meta-analysis, Catheter Cardiovasc. Interv. 71(3), 318–324 (2008)
D.E. Kuhl, R.G. Edwards: Image separation radioisotope scanning, Radiology 80, 653–662 (1963)
D.A. Chesler, J.R.B. Hoop, G.L. Brownell: Transverse section imaging of myocardium with 13 NH4, J. Nucl. Med. 14, 623–627 (1973)
M.M. Ter-Pogossian, M.E. Phelps, E.J. Hoffman, N.A. Muullani: A positron emission transaxial tomography for nuclear medicine imaging (PETT), Radiology 114, 89–98 (1975)
Z.A. Fayad, V. Fuster: Clinical imaging of the high-risk or vulnerable atherosclerotic plaque, Circ. Res. 89, 305–316 (2001)
V. Saxena, I. Gonzales-Gomez, W.E. Laug: A non-invasive multimodal technique to monitor brain tumor vascularization, Phys. Med. Biol. 52, 5295–5308 (2007)
A. Luciani, E. Itti, A. Rahmouni, M. Meignan, O. Clement: Lymph node imaging: basic principles, Eur. J. Radiol. 58, 338–344 (2006)
A. Jordan, R. Scholz, P. Wust, H. Fähling, J. Krause, W. Wlodarczyk, B. Sander, T. Vogl, R. Felix: Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo, Int. J. Hyperth. 13(6), 587–605 (1997)
M. Magnani, L. Rossi, M. D’ascenzo, I. Panzani, L. Bigi, A. Zanella: Erythrocyte engineeringfor drug delivery and targeting, Biotechnol. Appl. Biochem. 8(1), 1–6 (1998)
J.G. Zheng, Z.M. Yao, C.Y. Shu, Y. Zhang, X. Zhang: Role of SPECT/CT in diagnosis of hepatic hemangiomas, World J. Gastroenterol. 11(34), 5336–5341 (2005)
S.I. Zink, S.K. Ohki, B. Stein, D.A. Zambuto, R.J. Rosenberg, J.J. Choi, D.S. Tubbs: Noninvasive evaluation of active lower gastrointestinal bleeding: comparison between contrast-enhanced MDCT and 99mTc-labeled RBC scintigraphy, AJR Am. J. Roentgenol. 181(4), 1107–1114 (2008)
D.M. Howarth: The role of nuclear medicine in the detection of acute gastrointestinal bleeding, Semin. Nucl. Med. 36(2), 133–146 (2006)
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Borgert, J., Gleich, B., Buzug, T.M. (2011). Magnetic Particle Imaging. In: Kramme, R., Hoffmann, KP., Pozos, R.S. (eds) Springer Handbook of Medical Technology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74658-4_24
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