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Practical Bioinformatics pp 169–190Cite as

Finding Missing tRNA Modification Genes: A Comparative Genomics Goldmine

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 15))

As the adapters between mRNAs and the elongating peptide chain, transfer RNAs (tRNA) are at the nexus of the genetic code and of the translation apparatus. Prior to their participation in translation, tRNAs must undergo extensive processing of the nascent transcript. The post-transcriptional processing of tRNAs involves a number of functionally distinct events essential for tRNA maturation (Altman et al. 1995; Björk 1995; Deutscher 1995; Westaway and Abelson 1995). The phenomenon of nucleoside modification is perhaps the most remarkable of these events, and results in a wealth of structural changes to the canonical nucleosides (Björk 1995). Although other RNA species also exhibit varying degrees of nucleoside modification, it is only in the tRNA that a rich structural diversity is realized.

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    Valérie de Crécy-Lagard

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  1. International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109, Warsaw, Poland

    Janusz M. Bujnicki

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Crécy-Lagard, V.d. (2008). Finding Missing tRNA Modification Genes: A Comparative Genomics Goldmine. In: Bujnicki, J.M. (eds) Practical Bioinformatics. Nucleic Acids and Molecular Biology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74268-5_8

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  • DOI: https://doi.org/10.1007/978-3-540-74268-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-74267-8

  • Online ISBN: 978-3-540-74268-5

  • eBook Packages: Springer Book Archive

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