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Predicting Functional Residues in DNA Glycosylases by Analysis of Structure and Conservation

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Practical Bioinformatics

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 15))

Almost every biochemist and molecular biologist with an interest in protein research confronts the question of the role played by individual amino acid residues in a specific polypeptide. The wide variety of experimental techniques available to address this question can be categorized into two general approaches: functional and structural. In the former case, the residue in question is chemically modified or mutated; in the latter, the relationships with neighboring residues are defined and biological function is inferred. Each approach has its advantages and limitations and the most accurate information is provided when both are used together.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, 630090, Novosibirsk, Russia

    Dmitry O. Zharkov

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  1. Dmitry O. Zharkov
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Editors and Affiliations

  1. International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109, Warsaw, Poland

    Janusz M. Bujnicki

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Zharkov, D.O. (2008). Predicting Functional Residues in DNA Glycosylases by Analysis of Structure and Conservation. In: Bujnicki, J.M. (eds) Practical Bioinformatics. Nucleic Acids and Molecular Biology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74268-5_11

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  • DOI: https://doi.org/10.1007/978-3-540-74268-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-74267-8

  • Online ISBN: 978-3-540-74268-5

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