The frequency of lifestyle-related diseases such as diabetes, hypertension and obesity has increased over the last few decades in the developed industrial nations. These diseases can lead to further serious conditions, such as cardiovascular and cerebrovascular diseases. The incidence of allergic diseases such as hay fever, asthma and allergic dermatitis has also been increasing, so that about 30% of the developed world’s population is now affected. The causes for increased disease incidence are likely to involve a complex interaction of genetics and the living environment with lifestyle choices such as the quality and quantity of food and level of physical activity. Prevention of lifestyle-related and allergic diseases has become increasingly important, since they seriously affect quality of life, and their economic costs have become a burden on even the most developed economies. Thus, there is a strong societal demand for effective prophylactic and mitigating therapies. Many foods are known to have qualities that reduce the risk of lifestylerelated diseases, some of which are due to bioactive peptides. Transgenic plants can thus be generated with components that have activity against lifestyle-related or allergic diseases. High-value-added crops, such as genetically engineered rice, that promote human health would have many benefits for consumers and producers alike, and should be socially acceptable irrespective of their genetic modification status by virtue of a net positive in any risk-benefit analysis.
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References
Arai S, Osawa T, Ohigashi H, et al. (2001) A mainstay of functional food science in Japan–history, present status, and future outlook. Biosci Biotechnol Biochem 65:1–13
Conrad U, Fiedler U (1998) Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol Biol 38:101–109
Croft AJ, Washida H, Okita TW, Ogawa M, Kumamaru T, Satoh H (2004) Targeting of proteins to endoplasmic reticulum-derived compartments in plants. The importance of RNA localization. Plant Physiol 136:3414–3419
Daniell H, Streatfield SJ, Wycoff K (2001) Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 6:219–226
Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF (1987) Glucogon-like peptide 1 stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84:3434–3438
Fischer R, Emans N (2000) Molecular farming of pharmaceutical proteins. Transgenic Res 9:279–299
Fischer R, Stoger E, Schillberg S, Christou P, Twyman RM (2004) Plant-based production of biopharmaceuticals. Curr Opin Plant Biol 7:152–158
Frew AJ (2003) Immunotherapy of allergic disease. J Allergy Clin Immunol 111:S712–S719
Hamada S, Ishiyama K, Sakulsingharoj C, et al. (2003) Dual regulated RNA transport pathways to the cortical region in developing rice endosperm. Plant Cell 15:2265–2272
Hirahara K, Tatsuta T, Takatori T, et al. (2001) Preclinical evaluation of an immunotherapeutic peptide comprising 7 T-cell determinats of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens. J Allergy Clin Immunol 108:94–100
Hiroi T, Takaiwa F (2006) Peptide immunotherapy for allergeic diseases using a rice-based edible vaccine. Curr Opin Allergy Clin Immunol 6:455–460
Hood EE, Woodard SL, Horn ME (2002) Monoclonal antibody manufacturing in transgenic plants–myths and realities. Curr Opin Biotechnol 13:630–635
Iida S (1995) Screening and genetic analysis of rice seed storage protein mutants. Gamma Field Symp 34:31–48
Kawagoe Y, Suzuki K, Tasaki M, et al. (2005) The critical role of disulfide bond formation in protein sorting in the endosperm of rice. Plant Cell 17:1141–1153
Kearney PM, Whelton M, Reynolds K, Whelton PK, He J (2004) Worldwide prevalence of hypertension: a systematic review. J Hypertens 22:11–19
Kitts DD, Weiler K (2003) Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr Pharm Des 9:1309–1323
Korhonen H, Pihlanto A (2003) Food-derived bioactive peptides – opportunities for designing future foods. Curr Pharm Des 9:1297–1308
Larche M, Wraith DC (2005) Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 11:S69–S76
Ma JKC, Pascal MW, Drake PW, Christou P (2003) The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 4:794–805
Matoba N, Usui H, Fujita H, Yoshikawa M (1999) A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett 452:181–184
Matoba N, Doyama N, Yamada Y, Maruyama N, Utsumi S Yoshikawa M (2001) Design and production of genetically modified soybean protein with anti-hypertensive activity by incorporating potent analogue of ovokinin (2–7). FEBS Lett 497:50–54
Mayer L, Shao L (2004) Therapeutic potential of oral tolerance. Nature Rev Immunol 4:407–419
Nagaoka S, Futamura Y, Miwa K, et al. (2001) Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin. Biochem Biophys Res Commun 281:11–17
Nandi S, Suzuki YA, Huang J, et al. (2002) Expression of human lactoferrin in transgenic rice grains for the application in infant formula. Plant Sci 163:713–722
Nicolson DJ, Dikinson HO, Campbell F, Mason JM (2004) Lifestyle interventions or drugs for patients with essential hypertension: a systematic review. J Hypertens 22:2043–2048
Onishi K, Matoba N, Yamada Y, et al. (2004) Optimal designing of beta-conglycinin to genetically incorporate RPLKPW, a potent anti-hypertensive peptide. Peptides 25:37–43
Onodera Y, Suzuki A, Wu CY, Washida H, Takaiwa F (2001) A rice functional transcriptional activator, RISBZ1, responsible for endosperm-specific expression of storage protein genes through GCN4 motif. J Biol Chem 276:14139–14152
Prak K, Maruyama Y, Maruyama N, Utsumi S (2006) Design of genetically modified soybean proglycinin A1aB1b with multiple copies of bioactive peptide sequences. Peptide 27:1179–1186
Qu LQ, Takaiwa F (2004) Evaluation of tissue specificity and expression strength of rice seed component gene promoters in transgenic rice. Plant Biotech J 2:113–125
Rutherfurd-Markwick KJ, Moughan PJ (2005) Bioactive peptides derived from food. J AOAC Int 88:955–966
Schouten A, Roosien J, van Engelen FA, et al. (1996) The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco. Plant Mol Biol 30:781–793
Sharma A, Sharma R, Imamura M, Yamakawa M, Machii H (2000) Transgenic expression of cecropin B, an antibacterial peptide from Bombyx mori, confers enhanced resistance to bacterial leaf blight in rice. FEBS Lett 484:7–11
Stoger E, Ma JKC, Fischer R, Christou P (2005) Sowing the seeds of success: pharmaceutical proteins from plants. Curr Opin Biotech 16:167–173
Sugita K, Endo-Kasahara S, Tada Y, et al. (2005) Genetically modified rice seeds accumulating GLP-1 analogue stimulate insulin secretion from a mouse pancreatic beta-cell line. FEBS Lett 579:1085–1088
Tada Y, Utsumi S, Takaiwa F (2003) Foreign gene products can be enhanced by introduction into low storage protein mutants. Plant Biotech J 1:411–422
Takagi H, Hiroi T, Yang L, et al. (2005a) A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci USA 102:17525–17530
Takagi H, Saito S, Yang L, Nagasaka S, Nishizawa N, Takaiwa F (2005b) Oral immunotherapy against a pollen allergy using a seed-based peptide vaccine. Plant Biotech J 3:521–533
Takagi H, Hirose S, Yasuda H, Takaiwa F (2006) Biochemical safety evaluation of transgenic rice seeds expressing T cell epitopes of Japanese cedar pollen allergens. J Agric Food Chem 54:9901–9905
Takaiwa F, Takagi H, Hirose S, Wakasa Y (2007) Endosperm tissue is good production platform for artificial recombinant proteins in transgenic rice. Plant Biotech J 5:84–92
Torres E, Gonzalez-Melendi P, Stoger E, et al. (2001) Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments. Plant Physiol 127:1212–1223
Twyman RM, Stoger E, Schillberg S, Christou P, Fischer R (2003) Molecular farming in plants: host systems and expression technology. Trends Biotech 21:570–578
Wakasa Y, Yasuda H, Takaiwa F (2006) High accumulation of bioactive peptide in transgenic rice seeds by expression of introduced multiple genes. Plant Biotech J 4:499–510
Wallner BP, Gefter ML (1996) Peptide therapy for treatment of allergic diseases. Clin Immunol Immunopathol 80:105–109
Walmsley AM, Arntzen CJ (2000) Plants for delivery of edible vaccines. Curr Opin Biotech 11:126–129
Wandelt CI, Khan MRI, Craig S, Schroeder HE, Spencer D, Higgins TJV (1992) Vicillin with carboxy-terminal KDEL is retained in the endoplasmic reticulum and accumulates to high levels in the leaves of transgenic plants. Plant J 2:181–192
Weir GC, Mojsov S, Hendrick GK, Hebener JF (1989) Glucagon-like peptide 1 (7–37) actions on endocrine pancreas. Diabetes 38:338–342
Wu CY, Suzuki A, Washida H, Takaiwa F (1998) The GCN4 motif in a rice glutelin gene is essential for endosperm-specific gene expression and is activated by Opaque-2 in transgenic rice plants. Plant J 14:673–683
Yamada Y, Matoba N, Usui H, Onishi K, Yoshikawa M (2002) Design of a highly potent anti-hypertensive peptide based on ovokinin (2–7). Biosci Biotechnol Biochem 66:1213–1217
Yamamoto MP, Onodera Y, Touno SM, Takaiwa F (2006) Synergism between RPBF Dof and RISBZ1 bZIP activators in the regulation of rice seed expression genes. Plant Physiol 141:1694–1707
Yang LJ, Tada Y, Yamamoto MP, Zhao H, Yoshikawa M, Takaiwa F (2006) A transgenic rice seed accumulating an antihypertensive peptide reduces the blood pressure of spontaneously hypertensive rats. FEBS Lett 580:3315–3320
Yang SH, Moran DL, Jia HW, Bicar EH, Lee M, Scott MP (2002) Expression of a synthetic porcine α-lactoalbumin gene in the kernels of transgenic maize. Trangenic Res 11:11–20
Yasuda H, Tada Y, Hayashi Y, Jomori T, Takaiwa F (2005) Expression of the small peptide GLP-1 in transgenic plants. Trangenic Res 14:677–684
Yasuda H, Hayashi Y, Jomori T, Takaiwa F (2006) The correlation between expression and localization of a foreign gene product in rice endosperm. Plant Cell Physiol 47:756–763
Yoshikawa M, Fujita H, Matoba N, et al. (2000) Bioactive peptides derived from food proteins preventing lifestyle-related diseases. BioFactors 12:143–146
Yoshitomi T, Hirahara K, Kawaguchi J, et al. (2002) Three T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen antigens, retain their immunogenicity and tolerogenicity in a linked peptide. Immunology 107:517–522
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Takaiwa, F., Yang, L., Yasuda, H. (2008). Health-promoting Transgenic Rice: Application of Rice Seeds as a Direct Delivery System for Bioactive Peptides in Human Health. In: Hirano, HY., Sano, Y., Hirai, A., Sasaki, T. (eds) Rice Biology in the Genomics Era. Biotechnology in Agriculture and Forestry, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74250-0_26
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