Brucellosis affects millions of animals and humans world-wide; in humans, over 500,000 new cases are reported annually. Although some vaccines are available for its prevention in animals, none exist for humans. The causative agent is the facultative intracellular bacterial pathogen belonging to the genus Brucella and is transmitted from animals to humans; infected animals experience abortion and humans undulant fever. Brucella spp. belong to the order Rhizobiales within the class alpha-Proteobacteria. This places them in a group of bacteria noted for their abilities to live in soil (e.g. Ochrobactrum) or form close associations with their host and result in either a disease (e.g. phytopathogenic Agrobacterium) or non-disease state (symbiotic Rhizobium). The scientists contributing to the chapter have a vast array of experience in studying this intracellular bacterial pathogen. The topics covered include disease history, vaccines and zoonotic implications, taxonomy, diagnostic and population dynamics, comparative and functional genomics, and host pathogen interactions related to the Brucella spp. In all, the chapter is a comprehensive look at the Brucella and the means by which we are trying to minimize the negative impacts it has on the animal kingdom.
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Sriranganathan, N. et al. (2009). Brucella. In: Nene, V., Kole, C. (eds) Genome Mapping and Genomics in Animal-Associated Microbes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74042-1_1
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