The aim of this work is to describe the ongoing development of a non-invasive continuous glucose monitoring system based on Impedance Spectroscopy (IS). Previous work has shown the importance of taking a multi-sensor approach to aid in the compensation of various potentially perturbing parameters, such as the impact of environmental/body temperature, changes in the blood perfusion of the measured skin, underlying tissue volume and changes in the sensor / skin contact due to movements. Here we describe how this multisensor concept has been implemented into an integrated functional model (FM). In our recent studies, this integrated FM has been tested in an experimental clinical study in subject groups with patients with Diabetes type I/II (D) and healthy subjects (ND). The relation between changes in the blood glucose concentration and the impedance of the skin / underlying tissue has been investigated under controlled clinical conditions. The clinical study protocol allowed the use of an intravenous glucose clamp technique to control the subject’s glucose concentration and enabled two hyperglycemic episodes to be achieved within a ten hour study day.
- Blood Glucose Concentration
- Functional Model
- Continuous Glucose Monitoring
- Impedance Spectroscopy
- Underlying Tissue
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Talary, M., Dewarrat, F., Huber, D., Falco-Jonasson, L., Caduff, A. (2007). Non-Invasive Impedance based Continuous Glucose Monitoring System. In: Scharfetter, H., Merwa, R. (eds) 13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography. IFMBE Proceedings, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73841-1_164
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-73840-4
Online ISBN: 978-3-540-73841-1