Skip to main content

Non-Invasive Impedance based Continuous Glucose Monitoring System

  • Conference paper

Part of the IFMBE Proceedings book series (IFMBE,volume 17)


The aim of this work is to describe the ongoing development of a non-invasive continuous glucose monitoring system based on Impedance Spectroscopy (IS). Previous work has shown the importance of taking a multi-sensor approach to aid in the compensation of various potentially perturbing parameters, such as the impact of environmental/body temperature, changes in the blood perfusion of the measured skin, underlying tissue volume and changes in the sensor / skin contact due to movements. Here we describe how this multisensor concept has been implemented into an integrated functional model (FM). In our recent studies, this integrated FM has been tested in an experimental clinical study in subject groups with patients with Diabetes type I/II (D) and healthy subjects (ND). The relation between changes in the blood glucose concentration and the impedance of the skin / underlying tissue has been investigated under controlled clinical conditions. The clinical study protocol allowed the use of an intravenous glucose clamp technique to control the subject’s glucose concentration and enabled two hyperglycemic episodes to be achieved within a ten hour study day.


  • Blood Glucose Concentration
  • Functional Model
  • Continuous Glucose Monitoring
  • Impedance Spectroscopy
  • Underlying Tissue

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Khalil, OS (2004) Non-invasive glucose measurement technologies: an update from 1999 to the dawn of the new millennium. Diabetes Technol Ther 6(5):660-697.

    CrossRef  MathSciNet  Google Scholar 

  2. Caduff A, Dewarrat F, Talary MS et al. (2006) Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy. Biosens Bioelectron 22:598-604

    CrossRef  Google Scholar 

  3. Pfutzner A, Caduff A, Larbig M et al. (2004) Impact of posture and fixation technique on impedance spectroscopy used for continuous and noninvasive glucose monitoring. Diab TechnolTher 6:435-441.

    CrossRef  Google Scholar 

  4. Forst T, Caduff A, Talary M et al. (2006) Impact of Environmental Temperature on Skin Thickness and Microvascular Blood Flow in Subjects With and Without Diabetes. Diab Technol Ther 8:94-101.

    CrossRef  Google Scholar 

  5. Heinemann L and Ampudia-Blasco FJ (1994) Glucose clamps with the Biostator: a critical reappraisal. Horm Metab Res 26:579-583.

    CrossRef  Google Scholar 

  6. Huber D, Städler N, Jonasson L et al. (2007) Multisensor data fusion for non-invasive continuous glucose monitoring, submitted

    Google Scholar 

  7. Adrogue HJ, Madias NE (2000) Hyponatremia. N Engl J Med 342:1581-1589.

    CrossRef  Google Scholar 

  8. Talary MS, Dewarrat F, Huber D et al. (2007) In vivo life sign application of dielectric spectroscopy and non-invasive glucose monitoring. JNCS in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Editor information

Editors and Affiliations

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Talary, M., Dewarrat, F., Huber, D., Falco-Jonasson, L., Caduff, A. (2007). Non-Invasive Impedance based Continuous Glucose Monitoring System. In: Scharfetter, H., Merwa, R. (eds) 13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography. IFMBE Proceedings, vol 17. Springer, Berlin, Heidelberg.

Download citation

  • DOI:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-73840-4

  • Online ISBN: 978-3-540-73841-1

  • eBook Packages: EngineeringEngineering (R0)