Abstract
Acquired Glanzmann thrombasthenia is a rare bleeding disorder which is characterized by a blank bleeding history, rapid onset of bleeding tendency with a significantly prolonged bleeding time but normal platelet counts and normal expression of platelet membrane glycoproteins (GP). Etiologically, platelet antibodies bind on or close by the GP IIb and/or IIIa and inhibit binding of fibrinogen and von Willebrand factor (VWF) to platelets [1]. These antibodies mostly emerge in the scope of lymphoproliferative or autoimmune diseases. An association with a myelodysplastic syndrome (MDS) which we observed in our presented patient has not been described in the literature to our knowledge. This coincidence supports the thesis of loss of T cell regulation in MDS and establishes the basis for new immunosuppressive therapeutic approaches to acquired Glanzmann thrombasthenia.
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Trummer, A., Tiede, A., Eisert, R. (2008). Acquired Glanzmann Thrombasthenia in a Patient with Myelodysplastic Syndrome. In: Scharrer, I., Schramm, W. (eds) 37th Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73535-9_37
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DOI: https://doi.org/10.1007/978-3-540-73535-9_37
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