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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Modern head and neck cancer treatment, including accelerated and hyperfractionated fractionation schedules, are known to increase acute side effects to radiation. Furthermore, concurrent chemoradiation aggravates acute mucosal reaction (Brizel et al. 1998), which now has become the limiting factor in radical head and neck cancer treatment. For this reason, supportive care strategies are necessary to prevent, treat, and alleviate discomfort and to maintain nutrition and compliance to treatment.

Highly variable study designs, small sample sizes, and lack of consistent results do not allow strictly evidence-based recommendations for basic oral care and prevention and treatment of side effects, including mucositis (Rubenstein et al. 2004; Sutherland and Browman 2001). Consequentially, institutional strategies and oral care programs are based on guidelines with low levels of evidence or on clinical experience only.

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References

  • Andreassen CN, Grau C, Lindegaard JC (2003) Chemical radio-protection: a critical review of amifostine as a cytoprotec-tor in radiotherapy. Semin Radiat Oncol 13:62–72

    Article  PubMed  Google Scholar 

  • Arends J, Bodoky G, Bozzetti F et al. (2006) ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 25:245–259

    Article  PubMed  CAS  Google Scholar 

  • Beer KT, Krause KB, Zuercher T et al. (2005) Early percutaneous endoscopic gastrostomy insertion maintains nutritional state in patients with aerodigestive tract cancer. Nutr Cancer 52:29–34

    Article  PubMed  Google Scholar 

  • Belazi M, Velegraki A, Koussidou-Eremondi T et al. (2004) Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer: prevalence, azole susceptibility pro-fi les and response to antifungal treatment. Oral Microbiol Immunol 19:347–351

    Article  PubMed  CAS  Google Scholar 

  • Boström Å, Lindman H, Swartling C et al. (2001) Potent corti-costeroid cream (mometasone furoate) signifi cantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 59:257–265

    Article  PubMed  Google Scholar 

  • Brizel DM, Albers ME, Fisher SR et al. (1998) Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 338:1798–1804

    Article  PubMed  CAS  Google Scholar 

  • Brizel DM, Wasserman TH, Henke M et al. (2000) Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18:3339–3345

    PubMed  CAS  Google Scholar 

  • Browman G P, Mohide EA, Willan A et al. (2002) Association between smoking during radiotherapy and prognosis in head and neck cancer: a follow-up study. Head Neck 24:1031–1037

    Article  PubMed  Google Scholar 

  • Browman G P, Wong G, Hodson I et al. (1993) Infl uence of cigarette smoking on the effi cacy of radiation therapy in head and neck cancer. N Engl J Med 328:159–163

    Article  PubMed  CAS  Google Scholar 

  • Budach W, Bolke E, Homey B (2007) Severe cutaneous reaction during radiation therapy with concurrent cetuximab. N Engl J Med 357:514–515

    Article  PubMed  CAS  Google Scholar 

  • Buentzel J, Micke O, Adamietz IA et al. (2006) Intravenous ami-fostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study. Int J Radiat Oncol Biol Phys 64:684–691

    PubMed  CAS  Google Scholar 

  • Cady J (2007) Nutritional support during radiotherapy for head and neck cancer: the role of prophylactic feeding tube placement. Clin J Oncol Nurs 11:875–880

    Article  PubMed  Google Scholar 

  • Clarkson JE, Worthington H V, Eden OB (2007) Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev (2):CD001973

    Google Scholar 

  • Corvò R, Amichetti M, Ascarelli A et al. (2008) Effects of fl u-conazole in the prophylaxis of oropharyngeal candidiasis in patients undergoing radiotherapy for head and neck tumour: results from a double-blind placebo-controlled trial. Eur J Cancer Care 17:270–277

    Article  Google Scholar 

  • Davies AA, Smith GD, Harbord R et al. (2006) Nutritional interventions and outcome in patients with cancer or pre-invasive lesions: systematic review. J Natl Cancer Inst 98:961–973

    Article  PubMed  Google Scholar 

  • Donnelly S, Davis MP, Walsh D et al. (2002) Morphine in cancer pain management: a practical guide. Support Care Cancer 10:13–35

    Article  PubMed  Google Scholar 

  • El-Sayed S, Nabid A, Shelley W et al. (2002) Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III randomized, controlled trial evaluating the clinical effi -cacy of an antimicrobial lozenge using a validated mucosi-tis scoring system. J Clin Oncol 20:3956–3963

    Article  PubMed  CAS  Google Scholar 

  • Elting LS, Cooksley CD, Chambers MS et al. (2007) Risks, outcomes and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys 68:1110–1120

    PubMed  Google Scholar 

  • Epstein JB, Silverman S Jr, Paggiarino DA et al. (2001) Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Cancer 92: 875–885

    Article  PubMed  CAS  Google Scholar 

  • Finch PW, Rubin JS (2006) Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. JNCI 98:812–824

    PubMed  CAS  Google Scholar 

  • Fung SM, Ferrill MJ (2002) Granulocyte macrophage-colony stimulating factor and oral mucositis. Ann Pharmacother 36:517–520

    Article  PubMed  CAS  Google Scholar 

  • Foote RL, Loprinzi CL, Frank AR et al. (1994) Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis. J Clin Oncol 12:2630–2633

    PubMed  CAS  Google Scholar 

  • Franzén L, Bjermer L, Henriksson R et al. (1989) Does smoking protect against radiation-induced pneumonitis? Int J Radiat Biol 56:721–724

    Article  PubMed  Google Scholar 

  • Gillespie MB, Brodsky MB, Day TA et al. (2004) Swallowing-related quality of life after head and neck cancer treatment. Laryngoscope 114:1362–1367

    Article  PubMed  Google Scholar 

  • Grau C, Hansen HS, Specht L et al. (2006) Morbidity of accelerated radiotherapy for head and neck caner: prevalence and peak incidence of acute and late morbidity endpoints in the DAHANCA 6 & 7 randomized trial. Radiother Oncol 81(suppl 1):S130

    Google Scholar 

  • Henk JM (1997) Controlled trials of synchronous chemotherapy with radiotherapy in head and neck cancer: overview of radiation morbidity. Clin Oncol (R Coll Radiol) 9:308–312

    CAS  Google Scholar 

  • Isenring E, Hill J, Davidson W et al. (2008) Evidence based practice guidelines for the nutritional management of patients receiving radiation therapy. Nutr Diet 65(Suppl 1):S1–S20

    Google Scholar 

  • Jensen K, Jensen AB, Grau C (2007) Smoking has a negative impact upon health related quality of life after treatment for head and neck cancer. Oral Oncol 43:187–192

    Article  PubMed  Google Scholar 

  • Johansen J, Bertelsen A, Hansen CR et al. (2008) Setup errors in patients undergoing image guided radiation treatment. Relationship to body mass index and weight loss. Acta Oncologica 47(7):1454–1458

    Article  PubMed  Google Scholar 

  • Keefe DM, Rassias G, O'Neil L et al. (2007a) Severe mucositis: how can nutrition help? Cur Opin Clin Nutrit Metab Care 10:627–631

    Article  CAS  Google Scholar 

  • Keefe DM, Schubert MM, Elting LS et al. (2007b) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820–831

    Article  CAS  Google Scholar 

  • Kondrup J, Allison S P, Elia M et al. (2003) ESPEN guidelines for nutrition screening. Clin Nutr 22:415–421

    Article  PubMed  CAS  Google Scholar 

  • Koretz RL (2007) Should patients with cancer be offered nutritional support: does the benefit outweigh the burden?. Eur J Gastroenterol Hepatol 19:379–382

    Article  PubMed  Google Scholar 

  • Kwong KK (2004) Prevention and treatment of oropharyngeal mucositis following cancer therapy: are there new approaches? Cancer Nurs 27:183–205

    Article  PubMed  Google Scholar 

  • Lalla RV, Sonis ST, Peterson DE (2008) Management of oral mucositis in patients who have cancer. Dent Clin N Am 52:61–77

    Article  PubMed  Google Scholar 

  • Lee H, Havrila C, Bravo V et al. (2008) Effect of oral nutritional supplementation on weight loss and percutaneous endo-scopic gastrostomy tube rates in patients treated with radiotherapy for oropharyngeal carcinoma. Support Care Cancer 16:285–289

    Article  PubMed  Google Scholar 

  • Lees J (1999) Incidence of weight loss in head and neck cancer patients on commencing radiotherapy treatment at a regional oncology centre. Eur J Cancer Care (Engl) 8: 133–136

    Article  CAS  Google Scholar 

  • Löser C, Aschl G, Hébuterne X et al. (2005) ESPEN guidelines on artifi cial enteral nutrition – percutaneous endoscopic gastrostomy (PEG). Clin Nutr 24:848–861

    Article  PubMed  Google Scholar 

  • McDonnell AM, Lenz KL (2007) Palifermin: role in the prevention of chemotherapy- and radiation-induced mucositis. Ann Pharmacother 41:86–94

    PubMed  CAS  Google Scholar 

  • Mirabell R, Allal AS, Mermillod B et al. (1999) The infl uence of fi eld size and other radiotherapy parameters on acute tox-icity in pharyngolaryngeal cancer. Strahlenther Onkol 175:74–77

    Article  Google Scholar 

  • Momm F, Weissenberger C, Bartelt S et al. (2003) Moist skin care can diminish acute radiation-induced skin toxicity. Strahlenther Onkol 179:708–712

    Article  PubMed  Google Scholar 

  • Nicholson AB (2007) Methadone for cancer pain. Cochrane database Syst Rev (4):CD003971

    Google Scholar 

  • Overgaard J, Hansen HS, Specht L et al. (2003) Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet 362(9388):933–940

    Article  PubMed  Google Scholar 

  • Poulsen MG, Denham JW, Peters LJ et al. (2001) A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: a Trans-Tasman Radiation Oncology Group Study. Radiother Oncol 60:113–122

    Article  PubMed  CAS  Google Scholar 

  • Poulsen MG, Riddle B, Keller J et al. (2008) Predictors of acute grade 4 swallowing toxicity in patients with stages III and IV squamous carcinoma of the head and neck treated with radiotherapy alone. Radiother.Oncol 87:253–259

    Article  PubMed  Google Scholar 

  • Prada A, Chiesa F (1987) Effects of benzydamine on the oral mucositis during antineoplastic radiotherapy and/or intra-arterial chemotherapy. Int J Tissue React 9:115–119

    PubMed  CAS  Google Scholar 

  • Rabinovitch R, Grant B, Berkey BA et al. (2006) Impact of nutrition support on treatment outcome in patients with locally advanced head and neck squamous cell cancer treated with defi nitive radiotherapy: a secondary analysis of RTOG trial 90–03. Head Neck 28:287–296

    Article  PubMed  Google Scholar 

  • Ramirez-Amador V, Silverman S, Jr., Mayer P et al. (1997) Candidal colonization and oral candidiasis in patients undergoing oral and pharyngeal radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84:149–153

    Article  PubMed  CAS  Google Scholar 

  • Ravasco P, Monteiro-Grillo I, Marques VP et al. (2005) Impact of nutrition on outcome: a prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy. Head Neck 27:659–668

    Article  PubMed  Google Scholar 

  • Ringash J, Lockwood G, O'Sullivan B et al. (2008) Hyperfractionated, accelerated radiotherapy for locally advanced head and neck cancer: quality of life in a prospective phase I/II trial. Radiother Oncol 87:181–187

    Article  PubMed  Google Scholar 

  • Rosen LS, Ehtesham A, Davis ID et al. (2006) Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer receiving fl uorouracil-based chemotherapy. J Clin Oncol 24:5194–5200

    Article  PubMed  CAS  Google Scholar 

  • Rubenstein EB, Peterson DE, Schubert M et al. (2004) Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucosi-tis. Cancer 100(Suppl 9):2026–2046

    Article  PubMed  Google Scholar 

  • Rubin JS, Bottaro D P, Chedid M et al. (1995) Keratinocyte growth factor. Cell Biol Int 19:399–411

    Article  PubMed  CAS  Google Scholar 

  • Rugg T, Saunders MI, Dische S (1990) Smoking and mucosal reactions to radiotherapy. Br J Radiol 63:554–556

    Article  PubMed  CAS  Google Scholar 

  • Stokman MA, Spijkervet FK, Burlage FR et al. (2003) Oral mucositis and selective elimination of oral fl ora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial. Br J Cancer 88:1012–1016

    Article  PubMed  CAS  Google Scholar 

  • Stratton RJ, Elia M (2007) Who benefi ts from nutritional support: what is the evidence? Eur J Gastroenterol Hepatol 19:353–358

    Article  PubMed  Google Scholar 

  • Sutherland SE, Browman GP (2001) Prophylaxis of oral mucositis in irradiated head-and-neck cancer patients: a proposed classifi cation scheme of interventions and meta-analysis of randomized controlled trials. Int J Radiat Oncol Biol Phys 49:917–930

    Article  PubMed  CAS  Google Scholar 

  • Trotti A, Bellm LA, Epstein JB et al. (2003) Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol 66(3):253–262

    Article  PubMed  Google Scholar 

  • Van den Broek GB, Balm AJM, van den Brekel MWM et al. (2006) Relationship between clinical factors and the incidence of toxicity after intra-arterial chemoradiation for head and neck cancer. Radiother Oncol 81:143–150

    Article  PubMed  Google Scholar 

  • Waldron J, Warde P, Irish J et al. (2008) A dose escalation study of hyperfractionated accelerated radiation delivered with integrated neck surgery (HARDWINS) for the management of advanced head and neck cancer. Radiother.Oncol 87:173–180

    Article  PubMed  Google Scholar 

  • Worthington H V, Clarkson JE, Eden OB (2008) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev (4):CD000978

    Google Scholar 

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Johansen, J., Herrstedt, J. (2009). Supportive Therapy Including Nutrition. In: Harari, P.M., Connor, N.P., Grau, C. (eds) Functional Preservation and Quality of Life in Head and Neck Radiotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73232-7_26

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  • DOI: https://doi.org/10.1007/978-3-540-73232-7_26

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