Abstract
To investigate the mechanisms underlying the initiation and propagation of intracellular Ca 2 + waves, we developed a three-dimensional ventricular E-Cell (3Dv E-Cell), where cell membrane, nucleus, ryanodine receptor clusters, Z-disk, cytoplasm are modeled as spatially distributed structures. For the simulation of Ca 2 + sparks and Ca 2 + diffusion, a modified Fire-Diffuse-Fire model is used with stochastic rules for triggering Ca 2 + release. The 3Dv E-Cell is used to illustrate how stochastic properties of Ca 2 + sparks can lead to complex spatio-temporal intracellular wave processes and allows the incorporation of spatial data sets (protein distribution) into the geometry.
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Li, P., Lancaster, M., Holden, A.V. (2007). A Three Dimensional Ventricular E-Cell (3Dv E-Cell) with Stochastic Intracellular Ca 2 + Handling. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_19
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DOI: https://doi.org/10.1007/978-3-540-72907-5_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72906-8
Online ISBN: 978-3-540-72907-5
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