Zusammenfassung
Das breite Spektrum der gutartigen ekkrin und apokrin differenzierten Adnextumoren wird dargestellt und es wird auf histologische Varianten und morphologische Übergänge zwischen einzelnen Tumorentitäten hingewiesen. Da sich Porokarzinome, Spiradenokarzinome, Zylindrokarzinome und Hidradenokarzinome aus vorbestehenden gutartigen Läsionen entwickeln, werden die differentialdiagnostisch wichtigsten Abgrenzungskriterien dieser Karzinome dargestellt. Das mikrozystische Adnexkarzinom hat große Ähnlichkeit mit gutartigen syringoiden und follikulären Adnextumoren. Dieses Karzinom wird über den Nachweis des infiltrierenden Tumorwachstums mit perineuralen Tumorausläufern diagnostiziert. Die diagnostischen Herausforderungen im breiten morphologischen Spektrum des ausschließlich akral vorkommenden aggressiven digitalen papillären Adenokarzinoms werden besprochen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abenoza P, Ackermann AB (1990) Neoplasms with eccrine differentiation. Lea & Febiger, Philadelphia S. 373−412
Arai Y, Kusakabe H, Kiyokane K (2003) A case of syringocystadenocarcinoma papilliferum in situ occuring partially in syringocystadenoma papilliferum. J Dermatol 30:146−150
Argenyi ZB, Nguyen AV, Balogh K, Sears JK, Whitaker DC (1992) Malignant eccrine spiradenoma. Am J Dermatopathol 14:381−390
Armitage NC, Jass JR, Richman PI, Thomson JP, Phillips RK (1989) Paget’s disease of the anus: a clinicopathological study. Br J Surg 76:60−63
Armstrong DKB, Walsh MY, Corbett JR (1998) Multiple facial eccrine hidrocystomas: effective topical therapy with atropine. Br J Dermatol 139:558−559
Bellezza G, Sidoni A, Bucciarelli E (2000) Primary mucinous carcinoma of the skin. Am J Dermatopathol 22:166−170
Biernat W, Biernat S (1996) Cutaneous adnexal carcinoma arising within a solitary cylindroma-spiradenoma. Am J Dermatopathol 18:77−82
Bjarke T, Ternesten-Bratel A, Hedblad M, Rausing A (2003) Carcinoma and eccrine syringofibroadenoma: a report of five cases. J Cutan Pathol 30:382−392
Braun-Falco M, Hein R, Ring J (2001) Zylindrospiradenome bei Brooke-Spiegler-Syndrom. Hautarzt 52:1021−1025
Brown HM, Wilkinson EJ (2002) Uroplakin-III to distinguish primary vulvar Paget disease from Paget disease secondary to urothelial carcinoma. Hum Pathol 33:545−548
Carroll P, Goldstein GD, Brown CW (2000) Metastatic microcystic adnexal carcinoma in an immunocompromised patient. Dermatol Surg 26:531−534
Ceballos PI, Penneys NS, Acosta R (1990) Aggressive digital papillary adenocarcinoma. J Am Acad Dermatol 23:331−334
Chang SE, Ahn SJ, Choi JH, Sung KJ, Moon KC, Koh JK (1999) Primary adenoid cystic carcinoma of skin with lung metastasis.J Am Acad Dermatol 40:640−642
Cooper PH, Mills SE, Leonard DD, Santa Cruz DJ, Headington JT, Barr RJ, Katz DA (1985) Sclerosing sweat duct (syringomatous) carcinoma. Am J Surg Pathol 9:422−433
Coras B, Vogt T, Hohenleutner U, Landthaler M, Karrer S (2003) Porokeratotischer duktaler Naevus eccrinicus. JDDG 1:797−800
De Viragh PA, Szeimies RM, Eckert F (1997) Apocrine cystadenoma, apocrine hidrocystoma, and eccrine hidrocystoma: three distinct tumors defined by expressions of keratins and human milk fat globulin 1. J Cutan Pathol 24:249−255
Donner LR, Ruff T, Diaz JA (1995) Well-differentiated malignant cylindroma with partially preserved hyaline sheaths. Am J Dermatopathol 17:169−173
Duke WH, Sherrod TT, Lupton GP (2000) Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). Am J Surg Pathol 24:775−784
Eckert F, Pfau A, Landthaler M (1994) Das adenoid-zystische Schweißdrüsenkarzinom. Hautarzt 45:318−323
Eckert F, Schmid U, Hardmeier T, Altmannsberger M (1992) Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases. Histopathology 21:161−165
Fernandez-Acenero MJ, Sanchez TA, Sanchez MC, Requena L (2003) Ectopic hidradenoma papilliferum: a case report and literature review. Am J Dermatopathol 25:176−178
Fox SB, Cotton DWK (1992) Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? Am J Dermatopathol 14:149−154
Friedman PM, Friedman RH, Jiang B, Nouri K, Amonette R, Robins P (1999) Microcystic adnexal carcinoma: collaborative series review and update. J Am Acad Dermatol 41:225−231
Galadari E, Mehregan AH, Lee KC (1987) Malignant transformation of eccrine tumors. J Cutan Pathol 14:15−22
Gartmann H, Bieß B (1992) Verruköses mikrozystisches Adnexkarzinom der Nase. Z Hautkr 67:148−154
Gerretsen AL, van der Putte SC, Deenstra W, van Vloten WA (1993) Cutaneous cylindroma with malignant transformation. Cancer 72:1618−1623
Goldblum JR, Hart WR (1997) Vulvar Paget’s disease: a clinicopathologic and immunohistochemical study of 19 cases. Am J Surg Pathol 21:1178−1187
Goldblum JR, Hart WR (1998) Perianal Paget’s disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adcenocarcinoma. Am J Surg Pathol 22:170−179
Goldner R (1970) Eccrine poromatosis. Arch Derm 101:606−608
Goldstein DJ, Barr RJ, Santa Cruz DJ (1982) Microcystic adnexal carcinoma: a distinct clinicopathologic entitiy. Cancer 50:566−572
Granter SR, Seeger K, Calonje E, Busam K, McKee PH (2000) Malignant eccrine spiradenoma (Spiradenocarcinoma). Am J Dermatopath 22:97−103
Harvell JD, Kerschmann RL, LeBoit PE (1996) Eccrine or apocrine poroma? Six poromas with divergent adnexal differentiation. Am J Dermatopathol 18:1−9
Hassab-El-Naby HM, Tam S, White WL, Ackerman AB (1989) Mixed tumors of the skin. Am J Dermatopathol 11:413−428
Helwig EB, Hackney VC (1955) Syringadenoma papilliferum: lesions with and without nevus sebaceous and basal cell carcinoma. Arch Dermatol 71:361−372
Hernández-Pérez E, Cestoni-Parducci R (1985) Nodular hidradenoma und hidradenocarcinoma. J Am Acad Dermatol 12:15−20
Hirsch P, Helwig EB (1961) Chondroid syringoma. Arch Dermatol 84:835−847
Huet P, Dandurand M, Pignodel C, Guillot B (1996) Metastasizing eccrine porocarcinoma: report of a case and review of the literature. J Am Acad Dermatol 35:860−864
Ishida-Yamamoto A, Sato K, Wada T, Takahashi H, Iizuka H (2001) Syringocystadenocarcinoma papilliferum: case report and immunohistochemical comparison with its benign counterpart. J Am Acad Dermatol 45:755−759
Janniger CK, Brodkin RH (1990) Eruptive syringomas. Cutis 46:247−249
Jansen T, Kind P, Plewig G (1993) Ekkrin-angiomatöses Hamartom: Seltene Variante eines Schweißdrüsentumors. H+G 68:363−367
Johnson BL Jr., Helwig EB (1969) Eccrine acrospiroma. Cancer 23:641−657
Kao GF, Helwig EB, Graham JH (1987) Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. J Cutan Pathol 14:129−146
Karimipour DJ, Johnson TM, Kang S, Wang TS, Lowe L (1996) Mucinous carcinoma of the skin. J Am Acad Dermatol 34:323−326
Kato N, Yasukawa K, Onozuka T (1998) Primary cutaneous adenoid cystic carcinoma with lymph node metastasis. Am J Dermatopathol 20:571−577
Kersting DW (1963) Clear cell hidradenoma and hidradenocarcinoma. Arch Dermatol 87:323−333
Kiehl P, Vakilzadeh F, Richter K, Kapp A, Böcking A (1997) Identification of aneuploidy in recurrent clear cell hidradenoma by DNA image cytometry (ICM-DNA). J Cutan Pathol 24:314−321
Kolde G, Macher E, Grundmann E (1991) Metastasizing eccrine porocarcinoma: report of two cases with fatale outcome. Pathol Res Pract 187:477−481
Kuo HW, Ohara K (2003) Pigmented eccrine poroma: a report of two cases and study with dermatoscopy. Dermatol Surg 29:1076−1079
Langel DJ, Yeatts RP, White WL (2001) Primary signet ring cell carcinoma of the eyelid: report of a case demonstrating further analogy to lobular carcinoma of the breast with a literature review. Am J Dermatopathol 23:444−449
Langfritz K, Grabbe S, Kovacs G, Pötter R, Kolde G (1993) Metastasierendes ekkrines Porokarzinom. Hautarzt 44:176−179
Lau J, Kohler S (2003) Keratin profile of intraepidermal cells in Paget’s disease, extramammary Paget’s disease, and pagetoid squamous cell carcinoma in situ. J Cutan Pathol 30:449−454
LeBoit PE, Sexton M (1993) Microcystic adnexal carcinoma of the skin. J Am Acad Dermatol 29:609−618
Leonard N, Smith D, McNamara P (2003) Low-grade malignant eccrine spiradenoma with systemic metastases. Am J Dermatopathol 25:253−255
Maeda T, Mori H, Matsuo T, Nakagawa J, Yamauchi H, Tuziguchi H, Hongou Y (1996) Malignant eccrine poroma with multiple visceral metastases: report of a case with autopsy findings. J Cutan Pathol 23:566−570
Mazoujian G, Margolis R (1988) Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin. Am J Dermatopathol 10:28−35
Mehregan AH, Mehregan DA (1990) Syringoma-like sweat duct proliferation in scalp alopecias. J Cutan Pathol 17:355−357
Metze D, Wigbels B, Hildebrand A (2001) Familiäre Syringome: Eine seltene klinische Variante. Hautarzt 52:1045−1048
Metzler G, Schaumburg-Lever G, Hornstein O, Rassner G (1996) Malignant chondroid syringoma: immunohistopathology. Am J Dermatopathol 18:83−89
Meybehm M, Fischer HP, Lehringer-Polzin M (1993) Schweißdrüsenkarzinom auf dem Boden gruppierter Spiradenome. H+G 68:240−244
Moore TO, Orman HL, Orman SK, Helm KF (2001) Poromas of the head and neck. J Am Acad Dermatol 44:48−52
Neill JS, Park HK (1993) Apocrine nevus: light microscopic, immunohistochemical and ultrastructural studies of a case. J Cutan Pathol 20:79−83
Nickoloff BJ, Fleischmann HE, Carmel J, Wood CC, Roth RJ (1986) Microcystic adnexal carcinoma. Arch Dermatol 122:290−294
Numata M, Hosoe S, Itoh N, Munakata Y, Hayashi S, Maruyama Y (1985) Syringadenocarcinoma papilliferum. J Cutan Pathol 12:3−7
Patrizi A, Neri I, Marzaduri S (1998) Syringoma: a review of twenty-nine cases. Acta Derm Venereol 78:460−462
Pelle MT, Pride HB, Tyler WB (2002) Eccrine angiomatous hamartoma. J Am Acad Dermatol 47:429−435
Perniciaro C, Muller SA, Zelickson BD, Snow JL (1994) Hidroacanthoma spimplex: an ultrastructural and immunohistochemical study. J Cutan Pathol 21:274−279
Pinkus H, Rogin JR, Goldman P (1956) Eccrine poroma. Tumors exhibiting features of the epidermal sweat duct unit. Arch Dermatol 74:511−521
Pizinger K, Michal M (2000) Malignant cylindroma in Brooke-Spiegler syndrome. Dermatology 201:255−257
Pujol RM, LeBoit PE, Su WPD (1997) Microcystic adnexal carcinoma with extensive sebaceous differentiation. Am J Dermatopathol 19:358−362
Rank C, Bastian BC, Pistner H, Bröcker EB, Hamm H (1996) Das mikrozystische Adnexkarzinom der Haut. Hautarzt 47:284−288
Requena L, Kirya H, Ackermann AB (1998) Cylindrocarcinoma. In: Neoplasms with apocrine differentiation. Lippincott-Raven: S.733−750
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E (2001) Eccrine porocarcinoma (malignant eccrine poroma). Am J Surg Pathol 25:710−720
Ronnen M, Ben-Dor D, Huszar M (2002) Recurrent polymorphous sweat gland carcinoma of the skin. J Am Acad Dermatol 46:914−916
Rütten A (2002) Ekkrine Schweißdrüsenkarzinome der Haut. Pathologe 23:79−88
Rütten A, Kutzner H, Hügel H (1994) Das adenoid-zystische Karzinom der Haut. Akt Dermatol 20:119−121
Rütten A, Kutzner H, Sahre EM (1993) Spiradenokarzinom. Akt Dermatol 19:157−159
Rulon DB, Helwig EB (1977) Papillary eccrine adenoma. Arch Dermatol 113:596−598
Saitoh A, Ohtake N, Fukuda S, Tamaki K (1993) Clear cell of eccrine glands in a patient with clear cell syringoma associated with diabetes mellitus. Am J Dermatopathol 15:166−168
Sánchez Yus E, Aguilar A, Urbina F, Cristóbal MC, Vázquez F, Requena L (1988) Malignant cutaneous mixed tumor. Am J Dermatopathol 10:330−334
Santa Cruz DJ (1987) Sweat gland carcinomas: a comprehensive review. Semin Diagn Pathol 4:38−74
Santa Cruz DJ , Meyers JH, Gnepp DR, Perez BM (1978) Primary mucinous carcinoma of the skin. Br J Dermatol 98:645−653
Schwarze HP, Loche F, Lamant L, Kuchta J, Bazex J (2000) Microcystic adnexal carcinoma induced by multiple radiatic therapy. Int J Dermatol 39:369−372
Shvili D, Rothem A (1986) Fulminant metastasizing chrondoid syringoma of the skin. Am J Dermatopathol 8:321−325
Starink TM (1997) Eccrine syringofibroadenoma: multiple lesions representing a new cutaneous marker of the Schöpf syndrome, and solitary nonhereditary tumors. J Am Acad Dermatol 36:569−576
Stoof TJ, Starink TM, Nieboer C (1989) Porokeratotic eccrine ostial and dermal duct nevus. J Am Acad Dermatol 20:924−927
Swanson PE, Cherwitz DL, Neumann MP, Wick MR (1987) Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases. J Cutan Pathol 14:65−86
Swanson PE, Mazoujian G, Mills SE, Campbell RJ, Wick MR (1991) Immunoreactivity for estrogen receptor protein in sweat gland tumors. Am J Surg Pathol 15:835−841
Tateyama H, Eimoto T, Tada T, Inagaki H, Nakamura T, Yamauchi R (1995) p53 protein and proliferating cell nuclear antigen in eccrine poroma and porocarcinoma. Am J Dermatopathol 17:457−464
Tellechea O, Reis JP, Marques C et al. (1995) Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? Am J Dermatopathol 17:499−505
Urso C, Bondi R, Paglierani M, Salvadori A, Anichini C, Giannini A (2001) Carcinomas of sweat glands: report of 60 cases. Arch Pathol Lab Med 125:498−505
Urso C, Paglierani M, Bondi R (1993) Histologic spectrum of carcinomas with eccrine ductal differentiation (sweat-gland ductal carcinomas). Am J Dermatopathol 15:435−440
Vang R, Cohen PR (1999) Ectopic hidradenoma papilliferum: a case report and review of the literature. J Am Acad Dermatol 41:115−118
Veraldi S, Gianotti R, Pabisch S et al. (1991) Pigmented apocrine hidrocystoma − a report of two cases and review of the literature. Clin Exp Dermatol 16:18−21
Virgili A, Marzola A, Corazza M (2000) Vulvar hidradenoma papilliferum. A review of 10.5 years’ experience. J Reprod Med 45:616−618
Völter C, Baier G, Schwager K, Müller JG, Rose C (2002) Malignes dermales Zylindrom bei der Brooke-Spiegler-Phakomatose. Laryngo-Rhino-Otol 81:243−246
Vogelbruch M, Böcking A, Rütten A, Kapp A, Kiehl P (2000) DNA image cytometry in malignant und benign sweat gland tumours. Br J Dermatol 142:688−693
Welke S, Goos M (1982) Das chondroide Syringom. Hautarzt 33:15−17
Wick MR, Swanson PE (1986) Primary adenoid cystic carcinoma of the skin. Am J Dermatopathol 8:2−13
Winkelmann RK, McLeod WA (1966) The dermal duct tumor. Arch Dermatol 94:50−55
Yamamoto O, Doi Y, Hamada T, Hisaoka M, Sasaguri Y (2002) An immunohistochemical and ultrastructural study of syringocystadenoma papilliferum. Br J Dermatol 147:936−945
Yen A, Sanchez RL, Fearneyhough P, Tschen J, Wagner RF (1997) Mucoepidermoid carcinoma with cutaneous presentation. J Am Acad Dermatol 37:340−342
Zumdick M, Milde P, Ruzicka T, Hoelzle E (1995) Cutaneous apocrine mixed tumor with follicular differentiation. Hautarzt 46:481−484
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Rütten, A. (2009). Schweißdrüsentumoren. In: Cardesa, A., Rudolph, P., Mentzel, T., Slootweg, P. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72885-6_33
Download citation
DOI: https://doi.org/10.1007/978-3-540-72885-6_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72884-9
Online ISBN: 978-3-540-72885-6
eBook Packages: Medicine (German Language)