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Tumoren der Epidermis

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Pathologie

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Zusammenfassung

Die Epidermis als Grenzfläche zwischen Organismus und Umwelt ist einer Vielzahl äußerer Einflüsse ausgesetzt, von denen etliche ein tumorigenes oder gar karzinogenes Potenzial besitzen. Unter diesen spielt wahrscheinlich das UV-Licht eine zentrale Rolle, jedoch auch thermische, mechanische oder toxische Einwirkungen sowie pathogene Mikroorganismen können eine Bedeutung haben. Die meist virusinduzierten, seltener bakteriell bedingten tumoralen Epithelproliferationen werden unter dem Kapitel der infektiösen Hauterkrankungen abgehandelt.

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Literatur

  • Ackerman AB, de Viragh PA, Chongchitnant N (1993) Neoplasms with follicular differentiation.

    Google Scholar 

  • Altman J, Mehregan AH (1971) Inflammatory linear verrucose epidermal nevus. Arch Dermatol 104:385–389

    Article  PubMed  CAS  Google Scholar 

  • Argenyi ZB, Huston BM, Argenyi EE, Maillet MW, Hurt MA (1994) Large-cell acanthoma of the skin. A study by image analysis cytometry and immunohistochemistry. Am J Dermatopathol 16:140–144

    PubMed  CAS  Google Scholar 

  • Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63:8–18

    Article  PubMed  CAS  Google Scholar 

  • Aroni K, Lazaris AC, Nikolaou I, Saetta A, Kavantzas N, Davaris PS (2001) Signet ring basal cell carcinoma. A case study emphasizing the differential diagnosis of neoplasms with signet ring cell formation. Pathol Res Pract 197:853–856

    PubMed  CAS  Google Scholar 

  • Baer RL, Garcia RL, Partsalidou V, Ackerman AB (1981) Papillated squamous cell carcinoma in situ arising in a seborrheic keratosis. J Am Acad Dermatol 5:561–565

    Article  PubMed  CAS  Google Scholar 

  • Bale AE, Yu KP (2001) The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 10:757–762

    Article  PubMed  CAS  Google Scholar 

  • Barksdale SK, O’Connor N, Barnhill R (1997) Prognostic factors for cutaneous squamous cell and basal cell carcinoma. Determinants of risk of recurrence, metastasis, and development of subsequent skin cancers. Surg Oncol Clin N Am 6:625–638

    PubMed  CAS  Google Scholar 

  • Barr RJ, Graham JH (1979) Granular cell basal cell carcinoma. A distinct histopathologic entity. Arch Dermatol 115:1064–1067

    Article  PubMed  CAS  Google Scholar 

  • Basler RS, Jacobs SI, Taylor WB (1978) Ichthyosis hystrix. Arch Dermatol 114:1059–1060

    Article  PubMed  CAS  Google Scholar 

  • Battifora H, Silva EG (1986) The use of antikeratin antibodies in the immunohistochemical distinction between neuroendocrine (Merkel cell) carcinoma of the skin, lymphoma, and oat cell carcinoma. Cancer 58:1040–1046

    Article  PubMed  CAS  Google Scholar 

  • Becker SW (1951) Seborrheic keratosis and verruca, with special reference to the melanotic variety. AMA Arch Derm Syphilol 63:358–372

    PubMed  CAS  Google Scholar 

  • Beer TW, Shepherd P, Theaker JM (2000) Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin. Histopathology 37:218–223

    Article  PubMed  CAS  Google Scholar 

  • Berman A, Winkelmann RK (1978) Inflammatory seborrheic keratoses with mononuclear cell infiltration. J Cutan Pathol 5:353–360

    Article  PubMed  CAS  Google Scholar 

  • Bolshakov S, Walker CM, Strom SS, Selvan MS, Clayman GL, el Naggar A, Lippman SM, Kripke ML, Ananthaswamy HN (2003) p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. Clin Cancer Res 9:228–234

    PubMed  CAS  Google Scholar 

  • Bowman PH, Ratz JL, Knoepp TG, Barnes CJ, Finley EM (2003) Basosquamous carcinoma. Dermatol Surg 29:830–832

    Article  PubMed  Google Scholar 

  • Box NF, Duffy DL, Irving RE, Russell A, Chen W, Griffyths LR, Parsons PG, Green AC, Sturm RA (2001) Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. J Invest Dermatol 116:224–229

    Article  PubMed  CAS  Google Scholar 

  • Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ (1996) Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Investig Dermatol Symp Proc 1:136–142

    PubMed  CAS  Google Scholar 

  • Brenner B, Sulkes A, Rakowsky E, Feinmesser M, Yukelson A, Bar-Haim E, Katz A, Idelevich E, Neuman A, Barhana M, Fenig E (2001) Second neoplasms in patients with Merkel cell carcinoma. Cancer 91:1358–1362

    Article  PubMed  CAS  Google Scholar 

  • Brownstein MH, Fernando S, Shapiro L (1973) Clear cell acanthoma: clinicopathologic analysis of 37 new cases. Am J Clin Pathol 59:306–311

    PubMed  CAS  Google Scholar 

  • Burke JS (1985) Malignant lymphomas of the skin: their differentiation from lymphoid and nonlymphoid cutaneous infiltrates that simulate lymphoma. Semin Diagn Pathol 2:169–182

    PubMed  CAS  Google Scholar 

  • Byrd-Gloster AL, Khoor A, Glass LF, Messina JL, Whitsett JA, Livingston SK, Cagle PT (2000) Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor. Hum Pathol 31:58–62

    Article  PubMed  CAS  Google Scholar 

  • Campbell C, Quinn AG, Ro YS, Angus B, Rees JL (1993) p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin. J Invest Dermatol 100:746–748

    Article  PubMed  CAS  Google Scholar 

  • Centeno JA, Mullick FG, Martinez L, Page NP, Gibb H, Longfellow D, Thompson C, Ladich ER (2002) Pathology related to chronic arsenic exposure. Environ Health Perspect 110 Suppl 5:883–886

    PubMed  CAS  Google Scholar 

  • Cerroni L, Kerl H (1997) Primary cutaneous neuroendocrine (Merkel cell) carcinoma in association with squamous- and basal-cell carcinoma. Am J Dermatopathol 19:610–613

    Article  PubMed  CAS  Google Scholar 

  • Chan JK, Suster S, Wenig BM, Tsang WY, Chan JB, Lau AL (1997) Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 21:226–234

    Article  PubMed  CAS  Google Scholar 

  • Chang LC, Sheu HM, Huang YS, Kuo KW (2000) Quantitative determination of the expression of xeroderma pigmentosum F gene in human nonmelanoma skin cancers. Biochem Biophys Res Commun 273:454–458

    Article  PubMed  CAS  Google Scholar 

  • Cleaver JE, Crowley E (2002) UV damage, DNA repair and skin carcinogenesis. Front Biosci 7:d1024–d1043

    Article  PubMed  CAS  Google Scholar 

  • Cockerell CJ (2000) Histopathology of incipient intraepidermal squamous cell carcinoma („actinic keratosis“). J Am Acad Dermatol 42:11–17

    Article  PubMed  CAS  Google Scholar 

  • Cockerell CJ (2003) Pathology and pathobiology of the actinic (solar) keratosis. Br J Dermatol 149 Suppl 66:34–36

    Article  PubMed  Google Scholar 

  • Coit DG (2001) Merkel cell carcinoma. Ann Surg Oncol 8:99S–102S

    PubMed  CAS  Google Scholar 

  • Cook MG, Ridgway HA (1979) The intra-epidermal epithelioma of Jadassohn: a distinct entity. Br J Dermatol 101:659–667

    Article  PubMed  CAS  Google Scholar 

  • Couve-Privat S, Bouadjar B, Avril MF, Sarasin A, Daya-Grosjean L (2002) Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients. Cancer Res 62:7186–7189

    PubMed  CAS  Google Scholar 

  • Cramer SF, Heggeness LM (1989) Signet-ring squamous cell carcinoma. Am J Clin Pathol 91:488–491

    PubMed  CAS  Google Scholar 

  • Cramer SF, Mandel MA, Hauler R, Lever WF, Jenson AB (1981) Squamous cell carcinoma arising in a linear epidermal nevus. Arch Dermatol 117:222–224

    Article  PubMed  CAS  Google Scholar 

  • Czarnecki D, Meehan CJ, Bruce F, Culjak G (2002) The majority of cutaneous squamous cell carcinomas arise in actinic keratoses. J Cutan Med Surg 6:207–209

    PubMed  CAS  Google Scholar 

  • de Faria J (1985) Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma? J Clin Pathol 38:1273–1277

    Article  PubMed  Google Scholar 

  • Degos R, Delort J, Civatte J, Poiares BA (1962) [Epidermal tumor with an unusual appearance: clear cell acanthoma]. Ann Dermatol Syphiligr (Paris) 89:361–371

    CAS  Google Scholar 

  • Dumaz N, Drougard C, Sarasin A, Daya-Grosjean L (1993) Specific UV-induced mutation Natl Acad Sci U S A 90:10529–10533

    Article  CAS  Google Scholar 

  • Egawa K, Honda Y, Ono T, Kuroki M (1998) Immunohistochemical demonstration of carcinoembryonic antigen and related antigens in various cutaneous keratinous neoplasms and verruca vulgaris. Br J Dermatol 139:178–185

    Article  PubMed  CAS  Google Scholar 

  • Evans HL, Smith JL (1980) Spindle cell squamous carcinomas and sarcoma-like tumors of the skin: a comparative study of 38 cases. Cancer 45:2687–2697

    Article  PubMed  CAS  Google Scholar 

  • Farmer ER, Helwig EB (1980) Metastatic basal cell carcinoma: a clinicopathologic study of seventeen cases. Cancer 46:748–757

    Article  PubMed  CAS  Google Scholar 

  • Ferlicot S, Plantier F, Rethers L, Bui AD, Wechsler J (2000) Lymphoepithelioma-like carcinoma of stroma reaction. J Cutan Pathol 27:306–311

    Article  PubMed  CAS  Google Scholar 

  • Fitzpatrick JE, Whalen EA (1999) Basal cell carcinoma or not? Histological variants and mimics of the most common cutaneous malignancy. Semin Cutan Med Surg 18:15–24

    Article  PubMed  CAS  Google Scholar 

  • Forslund O, Ly H, Reid C, Higgins G (2003) A broad spectrum of human papillomavirus types is present in the skin of Australian patients with non-melanoma skin cancers and solar keratosis. Br J Dermatol 149:64–73

    Article  PubMed  CAS  Google Scholar 

  • Franchimont C, Pierard GE, Van Cauwenberge D, Damseaux M, Lapiere CH (1982) Episodic progression and regression of basal cell carcinomas. Br J Dermatol 106:305–310

    Article  PubMed  CAS  Google Scholar 

  • Frigerio B, Capella C, Eusebi V, Tenti P, Azzopardi JG (1983) Merkel cell carcinoma of the skin: the structure and origin of normal Merkel cells. Histopathology 7:229–249

    Article  PubMed  CAS  Google Scholar 

  • Garcia JA, Cohen PR, Herzberg AJ, Wallis ME, Rapini RP (1995) Pleomorphic basal cell carcinoma. J Am Acad Dermatol 32:740–746

    Article  PubMed  CAS  Google Scholar 

  • Giglia-Mari G, Sarasin A (2003) TP53 mutations in human skin cancers. Hum Mutat 21:217–228

    Article  PubMed  CAS  Google Scholar 

  • Goldberg HS (1980) Basal cell epitheliomas developing in a localized linear epidermal nevus. Cutis 25:295–7, 299

    PubMed  CAS  Google Scholar 

  • Gomez LG, DiMaio S, Silva EG, Mackay B (1983) Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skin. Am J Surg Pathol 7:171–177

    PubMed  CAS  Google Scholar 

  • Graham JH, Helwig EB (1973) Erythroplasia of Queyrat. A clinicopathologic and histochemical study. Cancer 32:1396–1414

    Article  PubMed  CAS  Google Scholar 

  • Gray MH, Smoller BS, McNutt NS (1991) Carcinogenesis in porokeratosis. Evidence for a role relating to chronic growth activation of keratinocytes. Am J Dermatopathol 13:438–444

    PubMed  CAS  Google Scholar 

  • Grob JJ, Rava MC, Gouvernet J, Fuentes P, Piana L, Gamerre M, Sarles JC, Bonerandi JJ (1991) The relation between seborrheic keratoses and malignant solid tumours. A case-control study. Acta Derm Venereol 71:166–169

    PubMed  CAS  Google Scholar 

  • Gushi A, Kanekura T, Kanzaki T, Eizuru Y (2003) Detection and sequences of human papillomavirus DNA in nongenital seborrhoeic keratosis of immunopotent individuals. J Dermatol Sci 31:143–149

    Article  PubMed  CAS  Google Scholar 

  • Happle R (1995) Epidermal nevus syndromes. Semin Dermatol 14:111–121

    Article  PubMed  CAS  Google Scholar 

  • Harrist TJ, Murphy GF, Mihm MC, Jr. (1980) Oral warty dyskeratoma. Arch Dermatol 116:929–931

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto K, Lee MW, D’Annunzio DR, Balle MR, Narisawa Y (1998) Pagetoid Merkel cell carcinoma: epidermal origin of the tumor. J Cutan Pathol 25:572–579

    Article  PubMed  CAS  Google Scholar 

  • Hattori H (2003) Merkel cell carcinoma composed of small, intermediate and squamous cell foci showing mutually exclusive expression of neuroendocrine markers and cytokeratin 20. Br J Dermatol 148:183–185

    Article  PubMed  CAS  Google Scholar 

  • Heenan PJ, Cole JM, Spagnolo DV (1990) Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). An adnexal epithelial neoplasm. Am J Dermatopathol 12:7–16:7–16

    Google Scholar 

  • Hemminki K, Zhang H, Czene K (2003) Time trends and familial risks in squamous cell carcinoma of the skin. Arch Dermatol 139:885–889

    Article  PubMed  Google Scholar 

  • Hitchcock CL, Bland KI, Laney RG, III, Franzini D, Harris B, Copeland EM, III (1988) 207:201–207

    Google Scholar 

  • Hodak E, Jones RE, Ackerman AB (1993) Solitary keratoacanthoma is a squamous-cell carcinoma: three examples with metastases. Am J Dermatopathol 15:332–342

    PubMed  CAS  Google Scholar 

  • Innocenzi D, Barduagni F, Cerio R, Wolter M (1994) Disseminated eruptive clear cell acanthoma--a case report with review of the literature. Clin Exp Dermatol 19:249–253

    Article  PubMed  CAS  Google Scholar 

  • Iyer PV, Leong AS (1992) Poorly differentiated squamous cell carcinomas of the skin can express vimentin. J Cutan Pathol 19:34–39

    Article  PubMed  CAS  Google Scholar 

  • Izaki S, Hirai A, Yoshizawa Y, Kitamura K, Inoue T, Hatoko M, Itoyama S, Inazu M (1993) Carcinosarcoma of the skin: immunohistochemical and electron microscopic observations. J Cutan Pathol 20:272–278

    Article  PubMed  CAS  Google Scholar 

  • Jimenez FJ, Burchette JLJ, Grichnik JM, Hitchcock MG (1995) Ber-EP4 immunoreactivity in normal skin and cutaneous neoplasms. Mod Pathol 8:854–858

    PubMed  CAS  Google Scholar 

  • Kaddu S, Dong H, Mayer G, Kerl H, Cerroni L (2002) Warty dyskeratoma − „follicular dyskeratoma“: analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm. J Am Acad Dermatol 47:423–428

    Article  PubMed  Google Scholar 

  • Kane CL, Keehn CA, Smithberger E, Glass LF (2004) Histopathology of cutaneous squamous cell carcinoma and its variants. Semin Cutan Med Surg 23:54–61

    Article  PubMed  Google Scholar 

  • Kao GF (1986) Carcinoma arising in Bowen’s disease. Arch Dermatol 122:1124–1126

    Article  PubMed  CAS  Google Scholar 

  • Kim YC, Vandersteen DP, Chung YJ, Myong NH (2001) Signet ring cell basal cell carcinoma: a basal cell carcinoma with myoepithelial differentiation. Am J Dermatopathol 23:525–529

    Article  PubMed  CAS  Google Scholar 

  • Koduru PR, Dicostanzo DP, Jhanwar SC (1989) Non random cytogenetic changes characterize Merkel cell carcinoma. Dis Markers 7:153–161

    PubMed  CAS  Google Scholar 

  • Koseki S, Aoki T, Ansai S, Hozumi Y, Mitsuhashi Y, Kondo S (1999) An immunohistochemical study of E-cadherin expression in human squamous cell carcinoma of the skin: relationship between decreased expression of E-cadherin in the primary lesion and regional lymph node metastasis. J Dermatol 26:416–422

    PubMed  CAS  Google Scholar 

  • Kossard S, Rosen R (1992) Cutaneous Bowen’s disease. An analysis of 1001 cases according to age, sex, and site. J Am Acad Dermatol 27:406–410

    PubMed  CAS  Google Scholar 

  • Kuo T (1980) Clear cell carcinoma of the skin. A variant of the squamous cell carcinoma that simulates sebaceous carcinoma. Am J Surg Pathol 4:573–583

    PubMed  CAS  Google Scholar 

  • Kwa RE, Campana K, Moy RL (1992) Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 26:1–26

    PubMed  CAS  Google Scholar 

  • Landman G, Taylor RM, Friedman KJ (1990) Cutaneous papillary squamous cell carcinoma. A report of two cases. J Cutan Pathol 17:105–110

    Article  PubMed  CAS  Google Scholar 

  • Langer K, Wuketich S, Konrad K (1994) Pigmented clear cell acanthoma. Am J Dermatopathol 16:134–139

    PubMed  CAS  Google Scholar 

  • Lear JT, Smith AG (1997) Basal cell carcinoma. Postgrad Med J 73:538–542

    PubMed  CAS  Google Scholar 

  • LeBoit PE (1995) Is keratoacanthoma a variant of squamous cell carcinoma. New insights into an old controversy ... soon? Am J Dermatopathol 17:319–320

    PubMed  CAS  Google Scholar 

  • Lehrer MS, Hershock D, Ming ME (2004) Merkel cell carcinoma. Curr Treat Options Oncol 5:195–199

    Article  PubMed  Google Scholar 

  • Lerchin E, Rahbari H (1975) Adamantinoid basal cell epithelioma. A histological variant. Arch Dermatol 111:586–588

    Article  PubMed  CAS  Google Scholar 

  • Lever WF (1947) Adenoacanthoma of sweat glands. Arch Dermatol Syphilol 56:157–171

    CAS  Google Scholar 

  • Lever WF (1983) Inverted follicular keratosis is an irritated seborrheic keratosis. Am J Dermatopathol 5:474

    Article  PubMed  CAS  Google Scholar 

  • Liang SB, Furihata M, Takeuchi T, Sonobe H, Ohtsuki Y (2001) Reduced human mismatch repair protein expression in the development of precancerous skin lesions to squamous cell carcinoma. Virchows Arch 439:622–627

    PubMed  CAS  Google Scholar 

  • Lind AC, Breer WA, Wick MR (1999) Lymphoepithelioma-like carcinoma of the skin with apparent origin in the epidermis − a pattern or an entity? A case report. Cancer 85:884–890

    Article  PubMed  CAS  Google Scholar 

  • Liu Y, Mangini J, Saad R, Silverman AR, Abell E, Tung MY, Graner SR, Silverman JF (2003) Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma. Appl Immunohistochem Mol Morphol 11:326–329

    PubMed  CAS  Google Scholar 

  • Mai KT, Alhalouly T, Landry D, Stinson WA, Perkins DG, Yazdi HM (2002) Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget’s disease. Histopathology 41:331–336

    Article  PubMed  CAS  Google Scholar 

  • Manaka L, Kadono S, Kawashima M, Kobayashi T, Imokawa G (2001) The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1. Br J Dermatol 145:895–903

    Article  PubMed  CAS  Google Scholar 

  • Marks R, Rennie G, Selwood T (1988) The relationship of basal cell carcinomas and squamous cell carcinomas to solar keratoses. Arch Dermatol 124:1039–1042

    Article  PubMed  CAS  Google Scholar 

  • Martin RC, Edwards MJ, Cawte TG, Sewell CL, McMasters KM (2000) Basosquamous carcinoma: analysis of prognostic factors influencing recurrence. Cancer 88:1365–1369

    Article  PubMed  Google Scholar 

  • Mazereeuw-Hautier J, Thibaut I, Bonafe JL (2002) Acantholytic dyskeratotic epidermal nevus: a rare histopathologic feature. J Cutan Pathol 29:52–54

    Article  PubMed  CAS  Google Scholar 

  • Miettinen M, Lasota J (1995) Cutaneous lymphoma-simulating Merkel cell carcinoma-molecular genetic demonstration of a clonal disease with divergent immunophenotypes. Mod Pathol 8:769–774

    PubMed  CAS  Google Scholar 

  • Mikhail GR, Mehregan AH (1982) Basal cell carcinoma in seborrheic keratosis. J Am Acad Dermatol 6:500–506

    PubMed  CAS  Google Scholar 

  • Mott RT, Smoller BR, Morgan MB (2004) Merkel cell carcinoma: a clinicopathologic study with prognostic implications. J Cutan Pathol 31:217–223

    Article  PubMed  Google Scholar 

  • Nappi O, Wick MR, Pettinato G, Ghiselli RW, Swanson PE (1992) Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. Am J Surg Pathol 16:429–438

    PubMed  CAS  Google Scholar 

  • Nasca MR, Innocenzi D, Micali G (1999) Penile cancer among patients with genital lichen sclerosus. J Am Acad Dermatol 41:911–914

    Article  PubMed  CAS  Google Scholar 

  • Ohnishi T, Watanabe S (1995) Immunohistochemical characterization of keratin expression in clear cell acanthoma. Br J Dermatol 133:186–193

    Article  PubMed  CAS  Google Scholar 

  • Olsen KE, Westermark P (1994) Amyloid in basal cell carcinoma and seborrheic keratosis. Acta Derm Venereol 74:273–275

    PubMed  CAS  Google Scholar 

  • Oram Y, Orengo I, Baer SC, Ocal T (1994) p53 Protein expression in squamous cell carcinomas from sun-exposed and non-sun-exposed sites. J Am Acad Dermatol 31:417–422

    PubMed  CAS  Google Scholar 

  • Ordonez NG (2000) Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am J Surg Pathol 24:1217–1223

    Article  PubMed  CAS  Google Scholar 

  • Patterson JW, Kao GF, Graham JH, Helwig EB (1986) Bowenoid papulosis. A clinicopathologic study with ultrastructural observations. Cancer 57:823–836

    Article  PubMed  CAS  Google Scholar 

  • Petter G, Haustein UF (2000) Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma. Dermatol Surg 26:521–530

    Article  PubMed  CAS  Google Scholar 

  • Porter WM, Francis N, Hawkins D, Dinneen M, Bunker CB (2002) Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. Br J Dermatol 147:1159–1165

    Article  PubMed  CAS  Google Scholar 

  • Rao BK, Freeman RG, Poulos EG, Arbesfeld L, Rendon M (1994) The relationship between basal cell epithelioma and seborrheic keratosis. A study of 60 cases. J Dermatol Surg Oncol 20:761–764

    PubMed  CAS  Google Scholar 

  • Reck A, Pathmanathan T, Lagnado R, Parham DM (1996) Clear cell basal carcinoma: an unusual variant. Histopathology 29:390–391

    Article  PubMed  CAS  Google Scholar 

  • Requena L, Martin L, Farina MC, Pique E, Escalonilla P (1996) Keloidal basal cell carcinoma. A new clinicopathological variant of basal cell carcinoma. Br J Dermatol 134:953–957

    Article  PubMed  CAS  Google Scholar 

  • Rippey JJ (1998) Why classify basal cell carcinomas? Histopathology 32:393–398

    Article  PubMed  CAS  Google Scholar 

  • Rulon DB, Helwig EB (1974) Cutaneous sebaceous neoplasms. Cancer 33:82–102

    Article  PubMed  CAS  Google Scholar 

  • Saldanha G, Fletcher A, Slater DN (2003) Basal cell carcinoma: a dermatopathological and molecular biological update. Br J Dermatol 148:195–202

    Article  PubMed  CAS  Google Scholar 

  • Sanchez YE, del Rio E, Requena L (1992) Large-cell acanthoma is a distinctive condition. Am J Dermatopathol 14:140–147

    Google Scholar 

  • Sanchez YE, Simon P, Requena L, Ambrojo P, de Eusebio E (2000) Solitary keratoacanthoma: a self-healing proliferation that frequently becomes malignant. Am J Dermatopathol 22:305–310

    Article  Google Scholar 

  • Schubert B, Rudolph P (2001) Basal cell carcinoma: a natural milieu for melanocytes? Am J Dermatopathol 23:558–560

    Article  PubMed  CAS  Google Scholar 

  • Schwartz RA (1995) Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 32:1–21

    Article  PubMed  CAS  Google Scholar 

  • Schwartz RA (1997) The actinic keratosis. A perspective and update. Dermatol Surg 23:1009–1019

    Article  PubMed  CAS  Google Scholar 

  • Serewko MM, Popa C, Dahler AL, Smith L, Strutton GM, Coman W, Dicker AJ, Saunders NA (2002) Alterations in gene expression and activity during squamous cell carcinoma development. Cancer Res 62:3759–3765

    PubMed  CAS  Google Scholar 

  • Sexton M, Jones DB, Maloney ME (1990) Histologic pattern analysis of basal cell carcinoma. Study of a series of 1039 consecutive neoplasms. J Am Acad Dermatol 23:1118–1126

    PubMed  CAS  Google Scholar 

  • Sibley RK, Dahl D (1985) Primary neuroendocrine (Merkel cell?) carcinoma of the skin. II. An immunocytochemical study of 21 cases. Am J Surg Pathol 9:109–116

    Article  PubMed  CAS  Google Scholar 

  • Sibley RK, Dehner LP, Rosai J (1985) Primary neuroendocrine (Merkel cell?) carcinoma of the skin. I. A clinicopathologic and ultrastructural study of 43 cases. Am J Surg Pathol 9:95–108

    Article  PubMed  CAS  Google Scholar 

  • Sigel JE, Skacel M, Bergfeld WF, House NS, Rabkin MS, Goldblum JR (2001) The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma. J Cutan Pathol 28:520–524

    Article  PubMed  CAS  Google Scholar 

  • Sina B, Kauffman CL (1995) Fibroepithelioma of Pinkus: eccrine duct spread of basal cell carcinoma. Am J Dermatopathol 17:634–636

    Article  PubMed  CAS  Google Scholar 

  • Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH (1997) Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol 37:734–739

    Article  PubMed  CAS  Google Scholar 

  • Smith PD, Patterson JW (2001) Merkel cell carcinoma (neuroendocrine carcinoma of the skin). Am J Clin Pathol 115 Suppl:S68–S78

    Google Scholar 

  • Solomon LM, Fretzin DF, Dewald RL (1968) The epidermal nevus syndrome. Arch Dermatol 97:273–285

    Article  PubMed  CAS  Google Scholar 

  • Spielvogel RL, Austin C, Ackerman AB (1983) Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. Am J Dermatopathol 5:427–442

    PubMed  CAS  Google Scholar 

  • Strutton GM (1997) Pathological variants of basal cell carcinoma. Australas J Dermatol 38 Suppl 1:S31–S35

    Google Scholar 

  • Sturm RA (2002) Skin colour and skin cancer – MC1R, the genetic link. Melanoma Res 12:405–416

    Article  PubMed  CAS  Google Scholar 

  • Su LD, Fullen DR, Lowe L, Uherova P, Schnitzer B, Valdez R (2002) CD117 (KIT receptor) expression in Merkel cell carcinoma. Am J Dermatopathol 24:289–293

    Article  PubMed  Google Scholar 

  • Su WP (1982) Histopathologic varieties of epidermal nevus. A study of 160 cases. Am J Dermatopathol 4:161–170

    Article  PubMed  CAS  Google Scholar 

  • Swanson SA, Cooper PH, Mills SE, Wick MR (1988) Lymphoepithelioma-like carcinoma of the skin. Mod Pathol 1:359–365

    PubMed  CAS  Google Scholar 

  • Szymanski FJ (1957) Warty dyskeratoma; a benign cutaneous tumor resembling Darier’s disease microscopically. AMA Arch Derm 75:567–572

    PubMed  CAS  Google Scholar 

  • Tagami H, Yamada M (1978) Seborrheic keratosis: an acantholytic variant. J Cutan Pathol 5:145–149

    Article  PubMed  CAS  Google Scholar 

  • Tatemoto Y, Saka M, Tanimura T, Mori M (1987) Immunohistochemical observations on binding of monoclonal antibody to epithelial membrane antigen in epithelial tumors of the oral cavity and skin. Oral Surg Oral Med Oral Pathol 64:721–726

    Article  PubMed  CAS  Google Scholar 

  • Tope WD, Nowfar-Rad M, Kist DA (2000) Ber-EP4-positive phenotype differentiates actinic keratosis from superficial basal cell carcinoma. Dermatol Surg 26:415–418

    Article  PubMed  CAS  Google Scholar 

  • Tozawa T, Ackerman AB (1987) Basal cell carcinoma with follicular differentiation. Am J Dermatopathol 9:474–482

    Article  PubMed  CAS  Google Scholar 

  • Tronnier M (2002) [Keratoacanthoma. A variant of highly differentiated squamous cell carcinoma and its differential diagnosis]. Pathologe 23:65–70

    Article  PubMed  CAS  Google Scholar 

  • Van Gele M, Boyle GM, Cook AL, Vandesompele J, Boonefaes T, Rottiers P, Van Roy N, De Paepe A, Parsons PG, Leonard JH, Speleman F (2004) Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma. Oncogene 23:2732–2742

    Article  PubMed  CAS  Google Scholar 

  • Van Gele M, Kaghad M, Leonard JH, Van Roy N, Naeyaert JM, Geerts ML, Van Belle S, Cocquyt V, Bridge J, Sciot R, Wolf-Peeters C, De Paepe A, Caput D, Speleman F (2000) Mutation analysis of P73 and TP53 in Merkel cell carcinoma. Br J Cancer 82:823–826

    Article  PubMed  Google Scholar 

  • Vandeweyer E, Sales F, Deraemaecker R (2001) Cutaneous verrucous carcinoma. Br J Plast Surg 54:168–170

    Article  PubMed  CAS  Google Scholar 

  • Vincent-Salomon A, de la RA, Salmon R, Validire P, Zafrani B, Sastre-Garau X (1996) Frequent association of human papillomavirus 16 and 18 DNA with anal squamous cell and basaloid carcinoma. Mod Pathol 9:614–620

    PubMed  CAS  Google Scholar 

  • Visscher D, Cooper PH, Zarbo RJ, Crissman JD (1989) Cutaneous neuroendocrine (Merkel cell) carcinoma: an immunophenotypic, clinicopathologic, and flow cytometric study. Mod Pathol 2:331–338

    PubMed  CAS  Google Scholar 

  • Walsh NM (2001) Primary neuroendocrine (Merkel cell) carcinoma of the skin: morphologic diversity and implications thereof. Hum Pathol 32:680–689

    Article  PubMed  CAS  Google Scholar 

  • Wick MR (1987) Monoclonal antibodies in diagnostic dermatopathology. Am J Dermatopathol 9:185–188

    PubMed  CAS  Google Scholar 

  • Wick MR (1999) Tumors of the epidermis. 2:969–1002

    Google Scholar 

  • Wieland U, Jurk S, Weissenborn S, Krieg T, Pfister H, Ritzkowsky A (2000) Erythroplasia of queyrat: coinfection with cutaneous carcinogenic human papillomavirus type 8 and genital papillomaviruses in a carcinoma in situ. J Invest Dermatol 115:396–401

    Article  PubMed  CAS  Google Scholar 

  • Yang DT, Holden JA, Florell SR (2004) CD117, CK20, TTF-1, and DNA topoisomerase II-alpha antigen expression in small cell tumors. J Cutan Pathol 31:254–261

    Article  PubMed  Google Scholar 

  • Yeatman JM, Kilkenny M, Marks R (1997) The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency? Br J Dermatol 137:411–414

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa K, Katagata Y, Kondo S (1995) Relative amounts of keratin 17 are higher than those of keratin 16 in hair-follicle-derived tumors in comparison with nonfollicular epithelial skin tumors. J Invest Dermatol 104:396–400

    Article  PubMed  CAS  Google Scholar 

  • Zabel RJ, Vinson RP, McCollough ML (2000) Malignant melanoma arising in a seborrheic keratosis. J Am Acad Dermatol 42:831–833

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Pathologisches Institut, Mühlenstr. 31, 45759, Recklinghausen, Deutschland

    Pierre Rudolph

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  1. Pierre Rudolph
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Editors and Affiliations

  1. Department of Pathological Anatomy, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spanien

    Antonio Cardesa

  2. Pathologisches Institut, Mühlenstr. 31, 45759, Recklinghausen, Deutschland

    Pierre Rudolph

  3. Dermatopathologische Gemeinschaftspraxis, Siemensstr. 6/1, 88048, Friedrichshafen, Deutschland

    Thomas Mentzel

  4. Department of Pathology HP 437, University Medical Center St. Radbound, P.O. Box 9101, 6500, Nijmegen, Niederlande

    Pieter J. Slootweg

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Rudolph, P. (2009). Tumoren der Epidermis. In: Cardesa, A., Rudolph, P., Mentzel, T., Slootweg, P. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72885-6_31

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  • DOI: https://doi.org/10.1007/978-3-540-72885-6_31

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