Abstract
Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling specificity. Compartmentation of cAMP signaling is maintained by the clustering of cAMP signaling enzymes in discrete units by the scaffolding protein A-kinase anchoring proteins (AKAP). In doing so, AKAPs provide the molecular architecture for the cAMP micordomains that underlie the spacial-temporal control of cAMP signaling.
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Abbreviations
- PKA:
-
cAMP-dependent protein kinase
- C:
-
PKA catalytic subunit
- RI:
-
PKA regulatory subunit type I
- RII:
-
PKA regulatory subunit type II
- AKAP:
-
A-kinase anchoring protein
- PDE:
-
Phosphodiesterase
- RyR:
-
Ryanodine receptor
- PP2A:
-
Protein phosphatase 2A
- Epac:
-
Exchange protein activated by cAMP
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Dodge-Kafka, K.L., Bauman, A., Kapiloff, M.S. (2008). A-Kinase Anchoring Proteins as the Basis for cAMP Signaling. In: Klussmann, E., Scott, J. (eds) Protein-Protein Interactions as New Drug Targets. Handbook of Experimental Pharmacology, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72843-6_1
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DOI: https://doi.org/10.1007/978-3-540-72843-6_1
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