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Voltage-Gated Calcium Channels in Nociception

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Book cover Sensing with Ion Channels

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 11))

Voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of membrane ion channels ubiquitously expressed throughout the central and peripheral nervous systems. VGCCs contribute to various physiological processes and transduce electrical activity into other cellular functions. This chapter provides an overview of biophysical properties of VGCCs, including regulation by auxiliary subunits, and their physiological role in neuronal functions. Subsequently, then we focus on N-type calcium (Cav2.2) channels, in particular their diversity and specific antagonists. We also discuss the role of N-type calcium channels in nociception and pain transmission through primary sensory dorsal root ganglion neurons (nociceptors). It has been shown that these channels are expressed predominantly in nerve terminals of the nociceptors and that they control neurotransmitter release. To date, important roles of N-type calcium channels in pain sensation have been elucidated genetically and pharmacologically, indicating that specific N-type calcium channel antagonists or modulators are particularly useful as therapeutic drugs targeting chronic and neuropathic pain.

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    Takahiro Yasuda & David J. Adams

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  1. University of Queensland, Qld 4072, Brisbane, Australia

    Boris Martinac

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© 2008 Springer-Verlag Berlin Heidelberg

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Yasuda, T., Adams, D.J. (2008). Voltage-Gated Calcium Channels in Nociception. In: Martinac, B. (eds) Sensing with Ion Channels. Springer Series in Biophysics, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72739-2_13

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