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Ultrasound Contrast Agents for Molecular Imaging

  • Chapter
Molecular Imaging I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 185/1))

Abstract

The successful use of targeted ultrasound contrast agents (USCAs) for qualitative US-based imaging has been shown by several academic and industrial research groups in different animal models. Furthermore, techniques have been developed that enable the in-vivo quantification of targeted microbubbles (MBs). USCAs for quantitative functional and molecular imaging in small animals can be used for a more detailed characterization of new and established disease models and provide quantitative biological insights into the interaction between drug and target or target and disease in living animals.

The advantages of such contrast agents in research and development are seen to be as follows:

  • new functional or molecular findings in the complex biology of disease development

  • these findings can lead to new therapeutic strategies or drug candidates

  • a better understanding of the treatment effects of new and existing drug candidates

  • a more sensitive and specific characterization of early treatment effects in living animals

  • identification of in-vivo biomarkers for translational medicine

Further outcomes are seen in speeding up the evaluation of new drug compounds and in a reduction of the number of animals used for biomedical research.

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Author information

Authors and Affiliations

  1. Global Drug Discovery, Bayer Schering Pharma AG, 13342, Berlin, Germany

    Peter Hauff & Michael Reinhardt

  2. Imaging Research, Sunnybrook and Women’s Research Institute, Toronto, ON, Canada

    Stuart Foster

Authors
  1. Peter Hauff
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  2. Michael Reinhardt
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  3. Stuart Foster
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Corresponding author

Correspondence to Peter Hauff .

Editor information

Editors and Affiliations

  1. Forschungsschwerpunkt Innovative Krebsdiagnostik und -therapie (E), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Wolfhard Semmler (Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020) (Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020)

  2. Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts des Isar des Technischen Universität München, Ismaninger Str. 22, 81675, München, Germany

    Markus Schwaiger

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Hauff, P., Reinhardt, M., Foster, S. (2008). Ultrasound Contrast Agents for Molecular Imaging. In: Semmler, W., Schwaiger, M. (eds) Molecular Imaging I. Handbook of Experimental Pharmacology, vol 185/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72718-7_11

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