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Drug-Induced Respiratory Disease in Cardiac Patients

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Integrated Cardiothoracic Imaging with MDCT

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

By definition, adverse reactions to drugs develop unpredictably in patients exposed to therapeutic doses of ‘drugs,’ which include such respiratory gases as dioxygen (O2) and nitric oxide (NO). Accordingly, misuse, disuse, drug interactions, deliberate or accidental overdoses, illicit drugs, and radiation therapy are outside the province of this chapter. Notwithstanding that, it is difficult to cover this topic without mentioning the features of respiratory reactions occasioned by abused substances, herbals, radiation therapy, overdoses of drugs, and procedures when these overlap with the features or are in the differentials list for drug-induced respiratory disease (Hagan and Burney 2007).

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References

  • Ahmed J, Philpott J, Lew GS, Blunt D (2005) Airway obstruction: a rare complication of thrombolytic therapy. J Laryngol Otol 119:819–821

    Article  CAS  PubMed  Google Scholar 

  • Alapat PM, Zimmerman JL (2008) Toxicology in the critical care unit. Chest 133:1006–1013

    Article  PubMed  Google Scholar 

  • al-Fallouji HK, Snow DG, Kuo MJ, Johnson PJ (1993) Spontaneous retropharyngeal haematoma: two cases and a review of the literature. J Laryngol Otol 107:649–650

    Article  CAS  PubMed  Google Scholar 

  • Babu KS, Salvi SS (2000) Aspirin and asthma. Chest 118:1470–1476

    Article  CAS  PubMed  Google Scholar 

  • Babu KS, Marshall BG (2004) Drug-induced airways diseases. Clin Chest Med 25:113–122

    Article  PubMed  Google Scholar 

  • Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD (2002) Acute fi brinous and organizing pneumonia. A histologic pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med 126:1064–1070

    PubMed  Google Scholar 

  • Bedrossian CW, Warren CJ, Ohar J, Bhan R (1997) Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry. Ann Diagn Pathol 1:47–56

    Article  CAS  PubMed  Google Scholar 

  • Bonniaud P, Camus C, Jibbaoui A, Kazambu K, Baudouin N, Foucher P, Camus P (2006) Drug-induced respiratory emergencies. In: Fein A, Kamholz S, Ost D (eds) Respiratory emergencies. Edward Arnold, London, pp 269–290

    Google Scholar 

  • Camus P, Martin WJ II, Rosenow EC III (2004) Amiodarone pulmonary toxicity. Clin Chest Med 25:65–76

    Article  PubMed  Google Scholar 

  • Camus P (2004) Drug-induced pleural disease. In: Bouros D (ed) Pleural disorders. M Dekker, New York, pp 317–352

    Google Scholar 

  • Champion L, Stern M, Israel-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H, Porcher R, Morelon E (2006) Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 144:505–509

    PubMed  Google Scholar 

  • Chiu AG, Krowiak EJ, Deeb ZE (2001) Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology. Laryngoscope 111:1729–1731

    Article  CAS  PubMed  Google Scholar 

  • Cleverley JR, Screaton NJ, Hiorns MP, Flint JD, Müller NL (2002) Drug-induced lung disease: high-resolution CT and histological findings. Clin Radiol 57:292–299

    Article  PubMed  Google Scholar 

  • Costabel U, Uzaslan E, Guzman J (2004) Bronchoalveolar lavage in drug-induced lung disease. Clin Chest Med 25:25–36

    Article  PubMed  Google Scholar 

  • Coudert B, Bailly F, André F, Lombard JN, Camus P (1992) Amiodarone pneumonitis: bronchoalveolar lavage findings in 15 patients and review of the literature. Chest 102:1005–1012

    Article  CAS  PubMed  Google Scholar 

  • Dean DE, Schultz DL, Powers RH (2001) Asphyxia due to angiotensin-converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease. J Forensic Sci 46:1239–1243

    CAS  PubMed  Google Scholar 

  • Di Pasquale G, Salpietro V, Boaron M (1990) Spontaneous mediastinal hematoma during therapy with oral anticoagulants. G Ital Cardiol 20:972–975

    PubMed  Google Scholar 

  • Dicpinigaitis PV (2006) Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Chest 129:169S–173S

    Article  CAS  PubMed  Google Scholar 

  • Donaldson L, Grant IS, Naysmith MR, Thomas JS (1998) Acute amiodarone-induced lung toxicity. Intensive Care Med 24:626–630

    Article  CAS  PubMed  Google Scholar 

  • Dransfield MT, Rowe SM, Johnson JE, Bailey WC, Gerald LB (2008) Use of beta blockers and the risk of death in hospitalised patients with acute exacerbations of COPD. Thorax 63:301–305

    Article  CAS  PubMed  Google Scholar 

  • Ernawati DK, Stafford L, Hughes JD (2008) Amiodarone-induced pulmonary toxicity. Br J Clin Pharmacol 66:82–87

    Article  CAS  PubMed  Google Scholar 

  • Etminan M, Gill S, Fitzgerald M, Samii A (2006) Challenges and opportunities for pharmacoepidemiology in drugtherapy decision making. J Clin Pharmacol 46:6–9

    Article  PubMed  Google Scholar 

  • Fernandez AB, Karas RH, Alsheikh-Ali AA, Thompson PD (2008) Statins and interstitial lung disease: A systematic review of the literature and of FDA adverse event reports. Chest 08-0943 (Epub ahead of print)

    Google Scholar 

  • Flieder DB, Travis WD (2004) Pathologic characteristics of drug-induced lung disease. Clin Chest Med 25:37–46

    Article  PubMed  Google Scholar 

  • Foucher P, Biour M, Blayac JP, Godard P, Sgro C, Kuhn M, Vergnon JM, Vervloet D, Pfitzenmeyer P, Ollagnier M, Mayaud C, Camus P (1997) Drugs that may injure the respiratory system. Eur Respir J 10:265–279

    Article  CAS  PubMed  Google Scholar 

  • Gluecker T, Capasso P, Schnyder P, Gudinchet F, Schaller MD, Revelly JP, Chiolero R, Vock P, Wicky S (1999) Clinical and radiologic features of pulmonary edema. Radio-Graphics 19:1507–1531; discussion 1532–1503

    CAS  Google Scholar 

  • Greenberger PA, Rotskoff BD, Lifschultz B (2007) Fatal anaphylaxis: postmortem findings and associated comorbid diseases. Ann Allergy Asthma Immunol 98:252–257

    Article  PubMed  Google Scholar 

  • Gruchalla RS, Pirmohamed M (2006) Clinical practice. Antibiotic allergy. N Engl J Med 354:601–609

    Article  CAS  PubMed  Google Scholar 

  • Hagan IG, Burney K (2007) Radiology of recreational drug abuse. RadioGraphics 27:919–940

    Article  PubMed  Google Scholar 

  • Hauser T, Mahr A, Metzler C, Coste J, Sommerstein R, Gross WL, Guillevin L, Hellmich B (2008) The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: a case-crossover study. Thorax 63:677–682

    Article  CAS  PubMed  Google Scholar 

  • Hayek ER, Speakman E, Rehmus E (2005) Acute doxorubicin cardiotoxicity. N Engl J Med 352:2456–2457

    Article  CAS  PubMed  Google Scholar 

  • Hill AB (1965) The environment and disease: association or causation?. Proc Roy Soc Med 58:295–300

    CAS  PubMed  Google Scholar 

  • Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S (2005) Herb-drug interactions: a literature review. Drugs 65:1239–1282

    Article  CAS  PubMed  Google Scholar 

  • Irey NS (1976) Tissue reactions to drugs. Am J Pathol 82:613–647

    CAS  PubMed  Google Scholar 

  • Iskandar SB, Kasasbeh ES, Mechleb BK, Garcia I, Jackson A, Fahrig S, Albalbissi K, Henry PD (2006) Alveolar hemorrhage: an underdiagnosed complication of treatment with glycoprotein IIb/IIIa inhibitors. J Interv Cardiol 19:356–363

    Article  PubMed  Google Scholar 

  • Johnson BD, Beck KC, Olson LJ, O’Malley KA, Allison TG, Squires RW, Gau GT (2001) Pulmonary function in patients with reduced left ventricular function. Chest 120:1869–1876

    Article  CAS  PubMed  Google Scholar 

  • Kaynar AM, Bhavani-Shankar K, Mushlin PS (1999) Lingual hematoma as a potential cause of upper airway obstruction. Anesth Analg 89:1573–1575

    Article  CAS  PubMed  Google Scholar 

  • Leuppi JD, Schnyder P, Hartmann K, Reinhart WH, Kuhn M (2001) Drug-induced bronchospasm: analysis of 187 spontaneously reported cases. Respiration 68:341–351

    Article  Google Scholar 

  • Levy JH, Adkinson NF Jr (2008) Anaphylaxis during cardiac surgery: implications for clinicians. Anesth Analg 106:392–403

    Article  PubMed  Google Scholar 

  • Low I, Stables S (2006) Anaphylactic deaths in Auckland, New Zealand: a review of coronial autopsies from 1985 to 2005. Pathology 38:328–332

    Article  PubMed  Google Scholar 

  • Mason JW (2001) Amiodarone pulmonary toxicity and Professor Hounsfi eld. J Cardiovasc Electrophysiol 12:437–438

    Article  CAS  PubMed  Google Scholar 

  • Matsuno O, Okubo T, Hiroshige S, Takenaka R, Ono E, Ueno T, Nureki S, Ando M, Miyazaki E, Kumamoto T (2007) Drug-induced lymphocyte stimulation test is not useful for the diagnosis of drug-induced pneumonia. Tohoku J Exp Med 212:49–53

    Article  PubMed  Google Scholar 

  • Moore TJ, Walsh CS, Cohen MR (2004) Reported adverse event cases of methemoglobinemia associated with benzocaine products. Arch Intern Med 164:1192–1196

    Article  PubMed  Google Scholar 

  • Morelock SY, Sahn SA (1999) Drugs and the pleura. Chest 116:212–221

    Article  CAS  PubMed  Google Scholar 

  • Myers JL, Kennedy JI, Plumb VJ (1987) Amiodarone lung: pathologic findings in clinically toxic patients. Hum Pathol 18:349–354

    Article  CAS  PubMed  Google Scholar 

  • Nanda S, Konnur N (2006) Adolescent drug and alcohol use in the 21st century. Pediatr Ann 35:193–199

    PubMed  Google Scholar 

  • Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30:239–245

    CAS  PubMed  Google Scholar 

  • Newcomb AE, Clarke CP (2005) Spontaneous pneumomediastinum: a benign curiosity or a signifi cant problem? Chest 128:3298–3302

    Article  PubMed  Google Scholar 

  • Picado C, Castillo JA, Montserrat JM, Agusti-Vidal A (1989) Aspirin-intolerance as a precipitating factor of lifethreatening attacks of asthma requiring mechanical ventilation. Eur Respir J 2:127–129

    CAS  PubMed  Google Scholar 

  • Plataki M, Bouros D (2004) Iatrogenic and rare pleural effusion. In: Bouros D (ed) Pleural disorders. M Dekker, New York, pp 897–913

    Google Scholar 

  • Pleskow WW, Stevenson DD, Mathison DA, Simon RA, Schatz M, Zeiger RS (1982) Aspirin desensitization in aspirinsensitive asthmatic patients: clinical manifestations and characterization of the refractory period. J Allergy Clin Immunol 69:11–19

    Article  CAS  PubMed  Google Scholar 

  • Pneumotox® (1997, 2008) http://www.pneumotox.com: (Website). Producers: P Foucher, P Camus. Last update: August 2008

    Google Scholar 

  • Popovsky MA (2008) Transfusion-related acute lung injury: Incidence, pathogenesis and the role of multicomponent apheresis in its prevention. Transfusion Med Hemother 35:76–79

    Article  Google Scholar 

  • Prosnitz RG, Chen YH, Marks LB (2005) Cardiac toxicity following thoracic radiation. Semin Oncol 32:S71–S80

    Article  PubMed  Google Scholar 

  • Pumphrey RSH (2000) Lessons from management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 30:1144–1150

    Article  CAS  PubMed  Google Scholar 

  • Pumphrey RS, Roberts IS (2000) Postmortem findings after fatal anaphylactic reactions. J Clin Pathol 53:273–276

    Article  CAS  PubMed  Google Scholar 

  • Rosado A, Vives R, Gonzalez R, Rodriguez J (2003) Can NSAIDs intolerance disappear? A study of three cases. Allergy 58:689–690

    Article  CAS  PubMed  Google Scholar 

  • Rothman RB (2000) The age-adjusted mortality rate from primary pulmonary hypertension, in age range 20 to 54 years, did not increase during the years of peak “Phen/Fen” use. Chest 118:1516–1517

    Article  CAS  PubMed  Google Scholar 

  • Rothman KJ, Lanes S, Sacks ST (2004) The reporting odds ratio and its advantages over the proportional reporting ratio. Pharmacoepidemiol Drug Safety 13:519–523

    Article  Google Scholar 

  • Rubin RL (2005) Drug-induced lupus. Toxicology 209:135–147

    Article  CAS  PubMed  Google Scholar 

  • Rubin RL (1999) Etiology and mechanisms of drug-induced lupus. Curr Opin Rheumatol 11:357–363

    Article  CAS  PubMed  Google Scholar 

  • Salpeter SR, Ormiston TM, Salpeter EE, Poole PJ, Cates CJ (2003) Cardioselective beta-blockers for chronic obstructive pulmonary disease: a meta-analysis. Respir Med 97:1094–1101

    Article  CAS  PubMed  Google Scholar 

  • Shojania KG (2000) Coumadin-induced lingual hemorrhage mimicking angioedema. Am J Med 109:77–78

    Article  CAS  PubMed  Google Scholar 

  • Silliman CC, Ambruso DR, Boshkov LK (2005) Transfusionrelated acute lung injury. Blood 105:2266–2273

    Article  CAS  PubMed  Google Scholar 

  • Skroubis G, Galiatsou E, Metafratzi Z, Karahaliou A, Kitsakos A, Nakos G (2005) Amiodarone-induced acute lung toxicity in an ICU setting. Acta Anaesthesiol Scand 49:569–571

    Article  CAS  PubMed  Google Scholar 

  • Sondhi D, Lippmann M, Murali G (2004) Airway compromise due to angiotensin-converting enzyme inhibitorinduced angioedema: clinical experience at a large community teaching hospital. Chest 126:400–404

    Article  CAS  PubMed  Google Scholar 

  • Souza CA, Muller NL, Johkoh T, Akira M (2006) Drug-induced eosinophilic pneumonia: high-resolution CT findings in 14 patients. AJR Am J Roentgenol 186:368–373

    Article  PubMed  Google Scholar 

  • Spitz DJ (2003) An unusual death in an asthmatic patient. Am J Forensic Med Pathol 24:271–272

    Article  PubMed  Google Scholar 

  • Srihari VH, Lee TW (2008) Evidence based case report — Pulmonary embolism in a patient taking clozapine. Br Med J 336:1499–1501

    Article  Google Scholar 

  • Stalnikowicz R, Amitai Y, Bentur Y (2004) Aphrodisiac druginduced hemolysis. J Toxicol Clin Toxicol 42:313–316

    Article  CAS  PubMed  Google Scholar 

  • Stelfox HT, Ahmed SB, Fiskio J, Bates DW (2004) Monitoring amiodarone’s toxicities: Recommendations, evidence, and clinical practice. Clin Pharmacol Ther 75:110–122

    Article  CAS  PubMed  Google Scholar 

  • Stewart JI, Chawla R, Lloyd JM, Kane GC (2008) Amiodarone pneumonitis. Respir Care 53:370–375

    PubMed  Google Scholar 

  • Sunderji R, Kanji Z, Gin K (2000) Pulmonary effects of low dose amiodarone: a review of the risks and recommendations for surveillance. Can J Cardiol 16:1435–1440

    CAS  PubMed  Google Scholar 

  • Troughton RW, Richards AM, Yandle TG, Frampton CM, Nicholls MG (2007) The effects of medications on circulating levels of cardiac natriuretic peptides. Ann Med 39:242–260

    Article  CAS  PubMed  Google Scholar 

  • van Mieghem W, Coolen L, Malysse I, Lacquet LM, Deneffe GJD, Demedts MGP (1994) Amiodarone and the development of ARDS after lung surgery. Chest 105:1642–1645

    Article  PubMed  Google Scholar 

  • Vaszar LT, Stevenson DD (2001) Aspirin-induced asthma. Clin Rev Allergy Immunol 21:71–87

    Article  CAS  PubMed  Google Scholar 

  • Vernhet H, Bousquet C, Durand G, Giron J, Senac JP (2001) Reversible amiodarone-induced lung disease: HRCT findings. Eur Radiol 11:1697–1703

    Article  CAS  PubMed  Google Scholar 

  • Webb LM, Lieberman P (2006) Anaphylaxis: a review of 601 cases. Ann Allergy Asthma Immunol 97:39–43

    Article  PubMed  Google Scholar 

  • Wright SE, Snowden CP, Athey SC, Leaver AA, Clarkson JM, Chapman CE, Roberts DRD, Wallis JP (2008) Acute lung injury after ruptured abdominal aortic aneurysm repair: The effect of excluding donations from females from the production of fresh frozen plasma. Crit Care Med 36:1796–1802

    Article  PubMed  Google Scholar 

  • Wright RO, Lewander WJ, Woolf AD (1999) Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 34:646–656

    Article  CAS  PubMed  Google Scholar 

  • Yahalom J, Portlock CS (2008) Long-term cardiac and pulmonary complications of cancer therapy. Hematol Oncol Clin North Am 22:305–318, VII

    Article  PubMed  Google Scholar 

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Camus, P., Camus, C., Foucher, P. (2009). Drug-Induced Respiratory Disease in Cardiac Patients. In: Rémy-Jardin, M., Rémy, J. (eds) Integrated Cardiothoracic Imaging with MDCT. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72387-5_9

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  • DOI: https://doi.org/10.1007/978-3-540-72387-5_9

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