Zusammenfassung
Der Begriff Ecstasy wird meistens synonym für 3,4- Methylendioxymethamphetamin (MDMA) verwandt. MDMA ist die verbreiteteste Jugenddroge nach Cannabis und in der Regel auch der einzige Inhaltsstoff der Ecstasypillen. Nur gelegentlich werden chemische Analoga wie 3,4-Methylendioxyamphetamin und 3,4-Methylendioxyethylamphetamin, die hinsichtlich ihrer Wirkungen kaum vom MDMA zu unterscheiden sind, als Ecstasy verkauft. Deutlich seltener beinhalten die Ecstasypillen andere Substanzen wie Amphetaminstimulanzien, Koffein u. a. Vereinfachend werden im Folgenden die Begriffe Ecstasy und MDMA synonym verwandt.
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15.4 Literatur
Azmitia EC (2007): Serotonin and brain: evolution, neuroplasticity, and homeostasis. Int Rev Neurobiol 77: 31–56.
Bolla KI, McCann UD, Ricaurte GA (1998): Memory impairment in abstinent MDMA („Ecstasy“) users. Neurology 51: 1532–1537.
Buchert R, Thomasius R, Petersen K, Wilke F, Obrocki J, Nebeling B et al. (2006): Reversibility of ecstasy-induced reduction in serotonin transporter availability in polydrug ecstasy users. Eur J Nucl Med Mol Imaging 33: 188–199.
Bzg A: Bundeszentrale für gesundheitliche Aufklärung (2001): Die Drogenaffinität Jugendlicher in der Bundesrepublik Deutschland 2001. Eine Wiederholungsbefragung der BZgA. Köln, Bundeszentrale für gesundheitliche Aufklärung
Chang L, Ernst T, Grob CS, Poland RE (1999): Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, „ecstasy“) users. J Magn Reson Imaging 10: 521–526.
Cowan RL, Lyoo IK, Sung SM, Ahn KH, Kim MJ, Hwang J et al. (2003): Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study. Drug Alcohol Depend 72: 225–235.
Cowan RL (2007): Neuroimaging research in human MDMA users: a review. Psychopharmacology (Berl) 189: 539–556.
Curran HV, Verheyden SL (2003): Altered response to tryptophan supplementation after long-term abstention from MDMA (ecstasy) is highly correlated with human memory function. Psychopharmacology (Berl) 169: 91–103.
Daumann J, Fimm B, Willmes K, Thron A, Gouzoulis-Mayfrank E (2003): Cerebral activation in abstinent ecstasy (MDMA) users during a working memory task: a functional magnetic resonance imaging (fMRI) study. Brain Res Cogn Brain Res 16: 479–487.
Daumann J, Fischermann T, Pilatus U, Thron A, Moeller-Hartmann W, Gouzoulis-Mayfrank E (2004): Proton magnetic resonance spectroscopy in ecstasy (MDMA) users. Neurosci Lett 362: 113–116.
Daumann J, Fischermann T, Heekeren K, Henke K, Thron A, Gouzoulis-Mayfrank E (2005): Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users. Psychopharmacology (Berl) 180: 607–611.
De Sola Llopis S, Miguelez-Pan M, Peña-Casanova J, et al. (2008): Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. J Psychopharmacol 22: 498–510.
De Win MM, Jager G, Booij J et al. (2008a): Neurotoxic effects of ecstasy on the thalamus. Br J Psychiatry 193: 289–296.
De Win MM, Jager G, Booij J et al. (2008b): Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users. Brainal 131: 2936–2945.
Fischer C, Hatzidimitriou G, Wlos J, Katz J, Ricaurte G (1995): Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/−)3,4-methylenedioxymethamphetamine (MDMA, „ecstasy“). J Neurosci 15: 5476–5485.
Fisk JE, Montgomery C, Wareing M, Murphy PN (2006): The effects of concurrent cannabis use among ecstasy users: neuroprotective or neurotoxic? Hum Psychopharmacol 21: 355–366.
Fox HC, McLean A, Turner JJ, Parrott AC, Rogers R, Sahakian BJ (2002): Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA („ecstasy“) polydrug users. Psychopharmacology (Berl) 162: 203–214.
Gouzoulis-Mayfrank E, Thimm B, Rezk M, Hensen G, Daumann J (2003): Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users. Prog Neuropsychopharmacol Biol Psychiatry 27: 819–827.
Gouzoulis-Mayfrank E, Fischermann T, Rezk M, Thimm B, Hensen G, Daumann J (2005): Memory performance in polyvalent MDMA (ecstasy) users who continue or discontinue MDMA use. Drug Alcohol Depend 78: 317–323.
Gouzoulis-Mayfrank E, Daumann J (2006a): Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage? Addiction 101: 348–361.
Gouzoulis-Mayfrank E, Daumann J (2006b): The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview. J Psychopharmacol 20: 188–193.
Gouzoulis-Mayfrank E, Daumann J (2009): Neurotoxicity of drugs of abuse — The case of methylenedioxyamphetamines (MDMA; ecstasy) and stimulant amphetamines. Dialogues in Clinical Neuroscience 11: 305–317.
Green AR, Mechan AO, Elliott JM, O’Shea E, Colado MI (2003): The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, „ecstasy“). Pharmacol Rev 55: 463–508.
Hatzidimitriou G, McCann UD, Ricaurte GA (1999): Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/−)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery. J Neurosci 19: 5096–5107.
Jacobs BL, Azmitia EC (1992): Structure and function of the brain serotonin system. Physiol Rev 72: 165–229.
Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JH (2004): Preliminary evidence of hippocampal dysfunction in adolescent MDMA („ecstasy“) users: possible relationship to neurotoxic effects. Psychopharmacology (Berl) 173: 383–390.
Kalechstein AD, De La GR, Mahoney JJ, III, Fantegrossi WE, Newton TF (2007): MDMA use and neurocognition: a meta-analytic review. Psychopharmacology (Berl) 189: 531–537.
Lundqvist T (2005): Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions. Pharmacol Biochem Behav 81: 319–330.
Lyvers M (2006): Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues. Drug Alcohol Rev 25: 269–276.
Morgan MJ (1998): Recreational use of „ecstasy“ (MDMA) is associated with elevated impulsivity. Neuropsychopharmacology 19: 252–264.
Morgan MJ, McFie L, Fleetwood H, Robinson JA (2002): Ecstasy (MDMA): are the psychological problems associated with its use reversed by prolonged abstinence? Psychopharmacology (Berl) 159: 294–303.
Morgan MJ, Impallomeni LC, Pirona A, Rogers RD (2006): Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naive Controls. Neuropsychopharmacology 31: 1562–1573.
Quednow BB, Jessen F, Kuhn KU, Maier W, Daum I, Wagner M (2006a): Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction. J Psychopharmacol 20: 373–384.
Quednow BB, Kuhn KU, Hoppe C, Westheide J, Maier W, Daum I et al. (2006b): Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA („Ecstasy“). Psychopharmacology (Berl): 1–14.
Reneman L, Majoie CB, Schmand B, van Den BW, den Heeten GJ (2001): Prefrontal N-acetylaspartate is strongly associated with memory performance in (abstinent) ecstasy users: preliminary report. Biol Psychiatry 50: 550–554.
Reneman L, Majoie CB, Flick H, den Heeten GJ (2002): Reduced N-acetylaspartate levels in the frontal cortex of 3,4-methylenedioxymethamphetamine (Ecstasy) users: preliminary results. AJNR Am J Neuroradiol 23: 231–237.
Reneman L, Schilt T, de Win MM, Booij J, Schmand B, van Den BW et al. (2006): Memory function and serotonin transporter promoter gene polymorphism in ecstasy (MDMA) users. J Psychopharmacol 20: 389–399.
Ricaurte GA, Martello AL, Katz JL, Martello MB (1992): Lasting effects of (+−)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations. J Pharmacol Exp Ther 261: 616–622.
Roiser JP, Rogers R, Sahakian BJ (2007): Neuropsychological function in ecstasy users: a study controlling for polydrug use. Psychopharmacology (Berl) 189: 505–516.
Schilt T, de Win MM, Koeter M et al. (2007): Cognition in novice ecstasy users with minimal exposure to other drugs: a prospective cohort study. Arch Gen Psychiatry 64: 728–736.
Thomasius R, Petersen K, Buchert R, Andresen B, Zapletalova P, Wartberg L et al. (2003): Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users. Psychopharmacology (Berl) 167: 85–96.
Thomasius R, Zapletalova P, Petersen K, Buchert R, Andresen B, Wartberg L et al. (2006): Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective. J Psychopharmacol 20: 211–225.
Ward J, Hall K, Haslam C (2006): Patterns of memory dysfunction in current and 2-year abstinent MDMA users. J Clin Exp Neuropsychol 28: 306–324.
Wareing M, Fisk JE, Murphy PN (2000): Working memory deficits in current and previous users of MDMA (‚ecstasy‘). Br J Psychol 91 (Pt 2): 181–188.
Wareing M, Fisk JE, Murphy P, Montgomery C (2004): Verbal working memory deficits in current and previous users of MDMA. Hum Psychopharmacol 19: 225–234.
Wareing M, Fisk JE, Murphy P, Montgomery C (2005): Visuo-spatial working memory deficits in current and former users of MDMA (‘ecstasy’). Hum Psychopharmacol 20: 115–123.
Zakzanis KK, Young DA (2001): Memory impairment in abstinent MDMA („Ecstasy“) users: a longitudinal investigation. Neurology 56: 966–969.
Zakzanis KK, Campbell Z (2006): Memory impairment in now abstinent MDMA users and continued users: a longitudinal follow-up. Neurology 66: 740–741.
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Gouzoulis-Mayfrank, E., Daumann, J. (2010). Neuropsychologie des Ecstasy-Abusus. In: Lautenbacher, S., Gauggel, S. (eds) Neuropsychologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72340-0_15
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