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Molecular Mechanisms of Radiation Induced Injury

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ALERT - Adverse Late Effects of Cancer Treatment

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Radiation-induced normal tissue injury represents a major impediment to the successful achievement of the desired clinical outcome from radiation therapy (RT) for cancer patients; usually improved local control, reduced risk for disease reoccurrence, and increased survival. Complications associated with RT can result in diminished quality of life and carries the potential for severe debilitating disease. The development of normal tissue protectors/radiomitigators is dependent on improved understanding of the molecular mechanisms associated with the development of acute and long-term RT-induced tissue toxicity. The following chapter provides a comprehensive review of the current state of knowledge with respect to those mechanisms underlying radiation-induced normal tissue pathologies. Future scientific endeavors will build upon this groundwork to delve deeper into the mechanistic understanding of disease onset and progression and develop new agents that can be translated from bench to bedside to reduce the risk for RT-induced complications.

In memory of George Casarett

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Authors and Affiliations

  1. Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

    Isabel L. Jackson & Zeljko Vujaskovic

  2. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA

    Phil Rubin

  3. Baylor University School of Medicine, Houston, Texas, 77030, USA

    Caroline Hadley

Authors
  1. Isabel L. Jackson
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  2. Phil Rubin
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  3. Caroline Hadley
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  4. Zeljko Vujaskovic
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Correspondence to Phil Rubin .

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Editors and Affiliations

  1. Dept. Radiation Oncology, University of Rochester Medical Center James P. Wilmot Cancer Ctr., Rochester, New York, USA

    Philip Rubin

  2. Department of Radiation Oncology, University of Rochester Medical Center James P. Wilmot Cancer Ctr., Rochester, New York, USA

    Louis S. Constine

  3. Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina, USA

    Lawrence B. Marks

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Jackson, I.L., Rubin, P., Hadley, C., Vujaskovic, Z. (2014). Molecular Mechanisms of Radiation Induced Injury. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT - Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72314-1_4

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