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The Molecular Basis of Antibody Protection Against West Nile Virus

  • Chapter
Human Antibody Therapeutics for Viral Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 317))

West Nile virus (WNV) infection of mosquitoes, birds, and vertebrates continues to spread in the Western Hemisphere. In humans, WNV infects the central nervous system and causes severe disease, primarily in the immunocompromised and elderly. In this review we discuss the mechanisms by which antibody controls WNV infection. Recent virologic, immunologic, and structural experiments have enhanced our understanding on how antibodies neutralize WNV and protect against disease. These advances have significant implications for the development of novel antibody-based therapies and targeted vaccines.

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  1. Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, 660 South Euclid Avenue, 8051, 63110, St. Louis, MO, USA

    M. S. Diamond & E. Mehlhop

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  1. Thomas Jefferson University, 1015 Walnut St, 19107, Philadelphia, PA, USA

    Scott K. Dessain MD, PhD

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Diamond, M.S., Mehlhop, E. (2008). The Molecular Basis of Antibody Protection Against West Nile Virus. In: Dessain, S.K. (eds) Human Antibody Therapeutics for Viral Disease. Current Topics in Microbiology and Immunology, vol 317. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72146-8_5

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