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Creating a Cardiac Pacemaker by Gene Therapy

  • Chapter
Biopacemaking

Part of the book series: Series in Biomedical Engineering ((BIOMENG))

Abstract

While electronic cardiac pacing in its various modalities represents standard of care for treatment of symptomatic bradyarrhythmias and heart failure, it has limitations ranging from absent or rudimentary autonomic modulation to severe complications. This has prompted experimental studies to design and validate a biological pacemaker that could supplement or replace electronic pacemakers. Advances in cardiac gene therapy have resulted in a number of strategies focused on β-adrenergic receptors as well as specific ion currents that contribute to pacemaker function. This article reviews basic pacemaker physiology, as well as studies in which gene transfer approaches to develop a biological pacemaker have been designed and validated in vivo. Additional requirements and refinements necessary for successful biopacemaker function by gene transfer are discussed.

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Authors and Affiliations

  1. Department of Medicine, Section of Cardiology, University of Illinois at Chicago, 840 South Wood Street, M/C 715, Chicago, IL, 60612, USA

    Traian M. Anghel & Steven M. Pogwizd

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  1. Traian M. Anghel
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  2. Steven M. Pogwizd
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Editors and Affiliations

  1. Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    J. A. E Spaan

  2. Department of Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    Ruben Coronel

  3. Department of Experimental Cardiology Center for Heart Failure Research, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam

    Jacques M. T. de Bakker

  4. The Heart Lung Center, University Medical Center, Utrecht

    Jacques M. T. de Bakker

  5. The Interuniversity Cardiology, Institute of the Netherlands, Utrecht, The Netherlands

    Jacques M. T. de Bakker

  6. Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy

    Antonio Zaza

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Anghel, T.M., Pogwizd, S.M. (2007). Creating a Cardiac Pacemaker by Gene Therapy. In: Spaan, J.A.E., Coronel, R., de Bakker, J.M.T., Zaza, A. (eds) Biopacemaking. Series in Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72110-9_4

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  • DOI: https://doi.org/10.1007/978-3-540-72110-9_4

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  • Online ISBN: 978-3-540-72110-9

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