Abstract
Despite advances in computer modelling and bioinformatics, animal models remain a vital component of biomedical research. The growth in this area of work is in part due to the evolution next generation of biotechnologies, which more than ever necessitate the need for in vivo experimentation. An understanding of the principals of animal research therefore remains a necessity for medical researchers as it permits scientific analysis to be interpreted in a more critical and meaningful manner. Initiating and designing an animal experiment can be a daunting process, particularly as the law and legislation governing animal research is complex and new specialist skills must be acquired. This chapter reviews the principles of animal research and provides a practical resource for those researchers seeking to create robust animal experiments that ensure minimal suffering and maximal scientific validity.
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- ACLAM:
-
The American College of Laboratory Animal Medicine
- APHIS:
-
Animal and Plant Health Inspection Service
- AWA:
-
Animal Welfare Act
- COSHH:
-
Control of substances hazardous to health
- ECBR:
-
European Coalition for Biomedical Research
- FDA:
-
The Food and Drug Agency
- H & SE:
-
Health and Safety Executive
- HFEA:
-
The Human Fertilisation and Embryology Authority
- IACUC:
-
Institutional Animal Care and Use Committee
- IVC:
-
Individually ventilated cage
- IVF:
-
In vitro fertilisation
- LAS:
-
Laboratory animal allergy
- NACWO:
-
Named animal care and welfare officer
- NICE:
-
National Institute for Clinical Excellence
- NVS:
-
Named veterinary surgeon
- OLAW:
-
The Office of Laboratory Animal Welfare
- PHS:
-
Public Health Service
- PIL:
-
Personal License under the Scientific (Animal Procedures) Act 1986
- PPL:
-
Project License under the Scientific (Animal Procedures) Act 1986
- RSPCA:
-
Royal Society for the Prevention of Cruelty to Animals
- SPF:
-
Specified pathogen free
- USDA:
-
The United States Department of Agriculture
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Kinross, J., Darzi, L.A. (2010). An Introduction to Animal Research. In: Athanasiou, T., Debas, H., Darzi, A. (eds) Key Topics in Surgical Research and Methodology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71915-1_17
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DOI: https://doi.org/10.1007/978-3-540-71915-1_17
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