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Immundefekte

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Therapie der Krankheiten im Kindes- und Jugendalter

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Dem menschlichen Abwehrsystem können unterschiedliche Aufgaben zugeordnet werden, z.B.:

  1. a)

    Abwehr von Infektionserregern (Bakterien, Viren, Pilze, Parasiten),

  2. b)

    Toleranz gegenüber körpereigenen Strukturen,

  3. c)

    Regulation von pathologischen Immunreaktionen gegen Allergene,

  4. d)

    Elimination von Tumorzellen.

Im Normalfall können all diese Funktionen in vollem Umfang wahrgenommen werden. Aus einem Verlust der unter a) erwähnten Funktion resultiert eine abnorme Anfälligkeit gegenüber Infektionen, beim Verlust der unter b) genannten Funktion kommt es zu Autoimmunerkrankungen. Werden Immunreaktionen, insbesondere IgE-vermittelte, gegenüber Allergenen der Umwelt (c) nicht kontrolliert, können sich allergische Erkrankungen entwickeln. Das Fehlen von d) trägt mit einer Reihe anderer Faktoren zur Entstehung von Malignomen bei.

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Authors and Affiliations

  1. Klinik m.S. Pädiatrische Pneumologie und Immunologie, Charité Campus Virchow, Augustenburger Platz 1, 13353, Berlin

    V. Wahn (Prof. Dr.)

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  1. V. Wahn
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Editors and Affiliations

  1. Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital, Klinikum der Universität München, Lindwurmstr. 4, 80337, München

    Dietrich Reinhardt

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Wahn, V. (2007). Immundefekte. In: Reinhardt, D. (eds) Therapie der Krankheiten im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71899-4_42

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  • DOI: https://doi.org/10.1007/978-3-540-71899-4_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71898-7

  • Online ISBN: 978-3-540-71899-4

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