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Pancreatic Cancer pp 79–93Cite as

Primary Advanced Unresectable Pancreatic Cancer

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 177))

Abstract

Median as well as overall survival of pancreatic cancer patients in the advanced stage is extremely low despite advances in cancer therapy regarding tumor cell biology, therapy resistance, and diagnosis. In matters of chemoradiation therapy (CRT) in locally advanced pancreatic cancer, favorable positive effect has been reached with different radiotherapy proceedings such as intraoperative radiation therapy with or without external chemo-/radiation therapy or with CRT alone with regard to local tumor pain, local tumor remission, or local control of disease and overall survival. Primary (chemo-) radiation therapy only rarely leads to local remission. Intraoperative radiation therapy (IORT) merely reaches pain palliation in most cases. By administering up-to-date primary CRT, especially with gemcitabine-associated CRT, local remission in up to 50% of patients can be observed.

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  1. Abt. für Strahlentherapie, Klinik Bad Trissl GmbH & Co. KG, Bad-Trissl-Str. 73, 83080, Oberaudorf, Germany

    Ralf Wilkowski, Maria Wolf & Volker Heinemann

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Wilkowski, R., Wolf, M., Heinemann, V. (2008). Primary Advanced Unresectable Pancreatic Cancer. In: Pancreatic Cancer. Recent Results in Cancer Research, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71279-4_10

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