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Cancer and Pregnancy pp 97–110Cite as

Leukaemia and Pregnancy

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 178))

Abstract

A PubMed search was undertaken using the grouped key words “leukaemia; pregnancy”: 3,067 references were found, with the earliest (a case report in a Dutch journal) published in 1949 [1]. Only papers with clinical data were considered for this review, with the selection arbitrarily focussing on more recent papers; the majority of these were single case reports. Special consideration was given to case series (all of them retrospective in design). For obvious reasons, in this particular field no prospective series or randomised trials are reported in the literature. More recent literature was deliberately given preference over articles published before the 1980s, since some of the major advances in diagnosis and therapy of leukaemia were achieved as of the early 1990s.

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References

  1. Bult JA, Heinemann H (1949) [Title not available.] Ned Tijschr Geneeskd 93: 2976–2980

    Google Scholar 

  2. Cardonick E, Iacobucci A (2004) Use of chemotherapy during human pregnancy. Lancet Oncol 5: 283–291

    Article  PubMed  CAS  Google Scholar 

  3. Pentheroudakis G, Pavlidis N (2006) Cancer and pregnancy: poena magna, not anymore. Eur J Cancer 42: 126–140

    Article  PubMed  Google Scholar 

  4. Dilek I, Topcu N, Demir C et al. (2006) Hematological malignancy and pregnancy: a single-institution experience of 21 cases. Clin Lab Haem 28: 170–176

    Article  CAS  Google Scholar 

  5. Greenlund L, Letendre L, Tefferi A (2001) Acute leukemia during pregnancy: a single institutional experience with 17 cases. Leuk Lymph 41: 571–577

    Article  CAS  Google Scholar 

  6. Peleg D, Ben Ami M (1998) Lymphoma and leukaemia complicating pregnancy. Obstet Gynecol Clin North Am 25:365–383

    Article  PubMed  CAS  Google Scholar 

  7. Brell J, Kalaycio M (2000) Leukemia in pregnancy. Semin Oncol 27: 667–677

    PubMed  CAS  Google Scholar 

  8. Segel GB, Lichtman MA (2004) Familial (inherited) leukemia, lymphoma, and myeloma: an overview. Blood Cells Mol Dis 32: 246–261

    Article  PubMed  Google Scholar 

  9. Song WJ et al. (1999) Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 23: 166–175

    Article  PubMed  CAS  Google Scholar 

  10. Sheikh SS, Mahmoud A, Khalifa et al. (1996) Acute monocytic leukemia (FAB M5) involving the placenta associated with delivery of a healthy infant: case report and discussion. Int J Gyn Pathol 15: 363–366

    CAS  Google Scholar 

  11. Potter JF, Schoenemann M (1970) Metastasis of maternal cancer to the placenta and fetus. Cancer 25: 380–388

    Article  PubMed  CAS  Google Scholar 

  12. Dildy GA, Moise KJ, Carpenter RJ et al. (1989) Maternal malignancy metastatic to the products of conception. A review. Obstet Gyn Surv 44: 535–540

    Article  Google Scholar 

  13. Bianchi D, Romero R (2003) Biological implications of bi-directional feto-maternal cell traffic: a summary of a National Institute of Child Health and Human Development-sponsored conference. J Matern Fetal Neonatal Med 14: 123–129

    Article  PubMed  CAS  Google Scholar 

  14. Osada S, Horibe K, Oiwa K et al. (1990) A case of infantile acute monocytic leukemia caused by vertical transmission of the mother’s leukemic cells. Cancer 65: 1146–1149.

    Article  PubMed  CAS  Google Scholar 

  15. Fey MF, Greil R, Jost LM (2005) ESMO Minimum Clinical Recommendations for the diagnosis, treatment and follow-up of acute myeloblastic leukemia (AML) in adult patients. Ann Oncol 16 (Suppl 1): i48–i49

    Google Scholar 

  16. Chelghoum Y, Vey N, Raffoux E et al. (2005) Acute leukaemia during pregnancy. Cancer 104: 110–117

    Article  PubMed  Google Scholar 

  17. Niedermeier DM, Frei-Lahr DA, Hall PD (2005) Treatment of acute myeloid leukemia during the second and third trimesters of pregnancy. Pharmacotherapy 25: 1134–1140

    Article  PubMed  Google Scholar 

  18. Ali R, Özkalemkas F, Özçelik T et al. (2003) Maternal and fetal outcomes in pregnancy complicated with acute leukemia: a single institutional experience with 10 pregnancies at 16 years. Leukemia Res 27: 381–385

    Article  Google Scholar 

  19. Giagounidis AAN, Beckmann MW, Giagounidis AS et al. (2000) Acute promyelocytic leukemia and pregnancy. Eur J Haematol 64: 267–271

    Article  PubMed  CAS  Google Scholar 

  20. Terada Y, Scindo T, Endoh A et al. (1991) Fetal arrhythmia during treatment of pregnancy-associated acute promyelocytic leukemia with all-trans retinoic acid and favorable outcome. J Cell Biochem 46: 302–311

    Article  Google Scholar 

  21. Consoli U, Figuera A, Milone G et al. (2004) Acute promyelocytic leukemia during pregnancy: report of 3 cases. Int J Hematol 79: 31–36

    Article  PubMed  Google Scholar 

  22. Lee DD, Park TS, Lee DS et al. (2005) Acute promyelocytic leukemia in late pregnancy with unusual secondary chromosomal change and its prognostic importance. Cancer Gen Cytogen 157: 92–93

    Article  CAS  Google Scholar 

  23. Fadilah S.A.W, Hatta A.Z., Keng C.S et al. (2001) Successful treatment of acute promyelocytic leukemia in pregnancy with all-trans retinoic acid. Leukemia 15: 1665–1666

    Article  PubMed  CAS  Google Scholar 

  24. Carradice D, Austin N, Bayston K et al. (2002) Successful treatment of acute promyelocytic leukaemia during pregnancy. Clin Lab Haem 24: 307–311

    Article  CAS  Google Scholar 

  25. Murrin RJA, Adjetey V, Harrison P et al. (2004) Acute promyelocytic leukaemia presenting as postpartum haemorrhage. Clin Lab Haem 26: 233–237

    Article  CAS  Google Scholar 

  26. Bazarbashi MS, Smith MR, Karanes CH et al. (1991) Successful management of Ph chromosome + chronic myelogenous leukemia with leukapheresis during pregnancy. Am J Hematol 38: 235–237

    Article  PubMed  CAS  Google Scholar 

  27. Strobl FJ, Voelkerding KV, Smith EP (1999) Management of chronic myeloid leukemia during pregnancy with leukapheresis. J Clin Apheresis 14: 42–44

    Article  PubMed  CAS  Google Scholar 

  28. Hensley ML, Ford JM (2003) Imatinib treatment: specific issues related to safety, fertility, and pregnancy. Semin Hematol 40: 21–25

    PubMed  CAS  Google Scholar 

  29. Prabhash K, Sastry PSRK, Biswas G et al. (2005) Pregnancy outcome of two patients treated with imatinib. Ann Oncol 16: 1983–1984

    Article  PubMed  CAS  Google Scholar 

  30. Ali R, Özkalemkas F, Özçelik T et al. (2005) Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML) Outcome of discontinuation of imatinib therapy after achieving a molecular remission. Leukemia Res 29: 971–973

    Article  CAS  Google Scholar 

  31. Heartin E, Walkinshaw S, Clark RE (2004) Successful outcome of pregnancy in chronic myeloid leukaemia treated with imatinib. Leuk Lymphoma 45: 1307–1308

    Article  PubMed  Google Scholar 

  32. Ault P, Kantarjian H, O’Brien S et al. (2006) Pregnancy among patients with chronic myeloid leukemia treated with Imatinib. J Clin Oncol 24: 1204–1208

    Article  PubMed  CAS  Google Scholar 

  33. AlKindi S, Dennison D, Pathare A (2005) Imatinib in pregnancy. Eur J Haematol 74: 535–537

    Article  PubMed  Google Scholar 

  34. Reichel RR, Linkesch W, Schetitska D (1992) Therapy with recombinant interferon alpha-2c during unexpected pregnancy in a patient with chronic myeloid leukaemia. Br J Haematol 82: 472–478

    PubMed  CAS  Google Scholar 

  35. Steensma DP, Tefferi A (2001) MDS and pregnancy—the Mayo Clinic experience. Leuk Lymph 42: 1229–1234

    Article  CAS  Google Scholar 

  36. Siddiqui T, Elfenbein GJ, Noyes WD et al. (1990) Myelodysplastic syndromes presenting in pregnancy. A report of five cases and the clinical outcome. Cancer 66: 377–381

    Article  PubMed  CAS  Google Scholar 

  37. Ikeda Y, Masuzaki H, Nakayama D et al. (2002) Successful management and perinatal outcome of pregnancy complicated with myelodysplastic syndrome. Leukemia Res 26: 255–260

    Article  Google Scholar 

  38. Molkenboer JF, Vos AH, Schouten HC et al. (2005) Acute lymphoblastic leukaemia in pregnancy. Neth J Med 63: 361–363

    PubMed  CAS  Google Scholar 

  39. Williams JK (1987) Hairy cell leukemia in pregnancy: a case report. Am J Obstet Gynecol 156: 210–211

    PubMed  CAS  Google Scholar 

  40. Baer MR, Ozer H, Foon KA (1992) Interferon-alpha therapy during pregnancy in chronic myelogenous leukaemia and hairy cell leukaemia. Br J Haematol 81: 167–169

    PubMed  CAS  Google Scholar 

  41. Alothman A, Sparling T (1994) Managing hairy cell leukaemia in pregnancy. Ann Int Med 120: 1048–1049

    PubMed  CAS  Google Scholar 

  42. Ali R, Özkalemkas F, Özkocaman V et al. (2004) Successful labor in the course of chronic lymphocytic leukemia (CLL) and management of CLL during pregnancy with leukapheresis. Ann Hematol 83: 61–63

    Article  PubMed  CAS  Google Scholar 

  43. Christomalis L, Baxi LV, Heller D (1996) Chronic lymphocytic leukemia in pregnancy. Am J Obstet Gynecol 175: 1381–1382

    Article  Google Scholar 

  44. Gürman G (2002) Pregnancy and successful labor in the course of chronic lymphocytic leukemia. Am J Hematol 71: 208–210

    Article  PubMed  Google Scholar 

  45. Kuroiwa M, Gondo H, Ashida K et al. (1998) Prolymphocytic transformation in chronic lymphocytic leukemia presenting a bilateral periorbital swelling. Am J Hematol 58: 98–102

    Google Scholar 

  46. Welsh TM, Thompson J, Lim S (2000) Chronic lymphocytic leukemia in pregnancy. Leukemia 14: 1155

    Article  PubMed  CAS  Google Scholar 

  47. Germann N, Goffinet F, Goldwasser F (2004) Anthracyclines during pregnancy: embryo-fetal outcome in 160 patients. Ann Oncol 15: 146–150

    Article  PubMed  CAS  Google Scholar 

  48. Achtari C, Hohlfeld P (2000) Cardiotoxic transplacental effect of idarubicin administered during the second trimester of pregnancy. Am J Obstet Gynecol 183: 511–512

    Article  PubMed  CAS  Google Scholar 

  49. Siu BL, Alonzo MR, Vargo TA et al. (2002) Transient dilated cardiomyopathy in a newborn exposed to idarubicin and all-trans-retinoic acid (ATRA) early in the second trimester of pregnancy. Int J Gynecol Cancer 12: 399–402

    Article  PubMed  CAS  Google Scholar 

  50. Meyer-Wittkopf M, Barth H, Emons G, Schmidt S (2001) Fetal cardiac effects of doxorubicin therapy for carcinoma of the breast during pregnancy: case report and review of the literature. Ultrasound Obstet Gynecol 18: 62–66

    Article  PubMed  CAS  Google Scholar 

  51. Morishita S, Imai A, Kawabata I et al. (1994) Acute myelogenous leukemia in pregnancy: fetal blood sampling and early effects of chemotherapy. Int J Gynecol Obstet 44: 273–277

    Article  CAS  Google Scholar 

  52. Murray NA, Acolet D, Deane M et al. (1994) Fetal marrow suppression after maternal chemotherapy for leukaemia. Arch Dis Child 71: F209–F210

    CAS  Google Scholar 

  53. Reynoso EE, Shepherd FA, Messner HA et al. (1987) Acute leukemia during pregnancy: the Toronto leukemia study group experience with long-term follow-up of children exposed in utero to chemotherapeutic agents. J Clin Oncol 5: 1098–1106

    PubMed  CAS  Google Scholar 

  54. Avilés A, Neri N, Nambo MJ (2006) Long-term evaluation of cardiac function in children who received anthracyclines during pregnancy. Ann Oncol 17: 286–288

    Article  PubMed  Google Scholar 

  55. Avilés A, Niz J (1988) Long-term follow-up of children born to mothers with acute leukemia during pregnancy. Med Ped Oncol 16: 3-6

    Google Scholar 

  56. Caligiuri MA, Mayer RJ (1989) Pregnancy and leukemia. Semin Oncol 16: 388–396

    PubMed  CAS  Google Scholar 

  57. Su WL, Liu JY, Kao WY (2003) Management of pregnancy-associated acute leukemia. Eur J Gyn Oncol 24: 251–254

    CAS  Google Scholar 

  58. Zuazu J, Julia A, Sierra J et al. (1991) Pregnancy outcome in hematologic malignancies. Cancer 67: 703–709

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Oncology, Inselspital and University, 3010, Bern, Switzerland

    Martin F. Fey & Daniel Surbek

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  1. Martin F. Fey
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  2. Daniel Surbek
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© 2008 Springer-Verlag Berlin Heidelberg

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Fey, M., Surbek, D. (2008). Leukaemia and Pregnancy. In: Cancer and Pregnancy. Recent Results in Cancer Research, vol 178. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71274-9_10

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  • DOI: https://doi.org/10.1007/978-3-540-71274-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71272-5

  • Online ISBN: 978-3-540-71274-9

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