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Diagnose, Ätiologie und Neuropathophysiologie der Schizophrenie

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Neuropsychologie der Schizophrenie

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Die Diagnostik in der Psychiatrie beruht auf den drei Säulen psychopathologischer Befund im Querschnitt, Ausschluss einer hirnorganischen Ursache und Beurteilung des Verlaufs. Da die Diagnose der Schizophrenie nach wie vor mit einem nicht unerheblichen Stigma verbunden ist und darüber hinaus der Diagnosestellung bei 80% der Betroffenen teilweise eine lebenslange medikamentöse Rezidivprophylaxe folgt, ist hierbei sorgfältiges Vorgehen dringend erforderlich.

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Literatur

  • Alzheimer A (1897) Beiträge zur pathologischen Anatomie der Hirnrinde und zur anatomischen Grundlage einiger Psychosen. Mschr Psychiatr Neurol 2: 82–120

    Google Scholar 

  • Barr AM et al. (2004) Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia. Eur J Neurosci 20(1): 303–307

    Article  PubMed  Google Scholar 

  • Bogerts B et al. (1985) Basal ganglia and limbic system pathology. Arch Gen Psychiatr 42: 784–791

    PubMed  CAS  Google Scholar 

  • Bogerts B et al. (1990) Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics. Initial results from a new brain collection. Schizophr Res 3(5–6): 295–301

    Article  PubMed  CAS  Google Scholar 

  • Caspi A et al. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301(5631): 386–389

    Article  PubMed  CAS  Google Scholar 

  • Corfas G et al. (2004) Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci 7(6): 575–580

    Article  PubMed  CAS  Google Scholar 

  • DeLisi LE et al. (1995) A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: preliminary findings. Biol Psychiatry 38(6): 349–360

    Article  PubMed  CAS  Google Scholar 

  • Ebner F et al. (2007) The hippocampus in families with schizophrenia in relation to obstetric complications. Schizophr Res (in press)

    Google Scholar 

  • Falkai P, Bogerts B (1995) The neuropathology of schizophrenia. In: Hirsch S, Weinberger D (eds) Schizophrenia. Blackwell, Oxford

    Google Scholar 

  • Falkai P, Maier W (2006) Fortschritte in der neurobiologischen Erforschung der Schizophrenie. Nervenarzt 77(Suppl 03): 65–76

    Article  Google Scholar 

  • Falkai P et al. (1999) No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study. Neuropathol Appl Neurobiol 25(1): 48–53

    Article  PubMed  CAS  Google Scholar 

  • Falkai P et al. (2000) Entorhinal cortex pre-alpha cell clusters in schizophrenia: quantitative evidence of a developmental abnormality. Biol Psychiatry 47(11): 937–943

    Article  PubMed  CAS  Google Scholar 

  • Gaebel W, Falkai P (2006) Praxisleitlinien in Psychiatrie und Psychotherapie, Bd 1. Behandlungsleitlinie Schizophrenie. Steinkopff, Darmstadt

    Google Scholar 

  • Harrison PJ, Law AJ (2006) Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60(2): 132–140

    PubMed  CAS  Google Scholar 

  • Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10(1): 40–68

    Article  PubMed  CAS  Google Scholar 

  • Hoff A et al. (1999) Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. Am J Psychiatry 156(9): 1336–1341

    PubMed  CAS  Google Scholar 

  • Huber G (1961) Chronische Schizophrenie. Synopsis klinischer und radiologischer Untersuchungen an defekt-schizophrenen Anstaltspatienten. Hüthig, Heidelberg

    Google Scholar 

  • Hulshoff Pol HE et al. (2001) Focal gray matter density changes in schizophrenia. Arch Gen Psychiatry 58(12): 1118–1125

    Article  PubMed  CAS  Google Scholar 

  • Hulshoff Pol HE et al. (2002) Volume changes in gray matter in patients with schizophrenia. Am J Psychiatry 159(2): 244–250

    Article  PubMed  Google Scholar 

  • Hulshoff Pol HE et al. (2004) Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia. Biol Psychiatry 55(2):126–130

    Article  PubMed  Google Scholar 

  • Hurlemann R et al. (2005) Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem. Anat Embryol 210(5–6): 513–517

    Article  PubMed  Google Scholar 

  • Isohanni M et al. (2001) Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophr Res 52(1–2): 1–19

    Article  PubMed  CAS  Google Scholar 

  • Jakob H, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65(3–4): 303–326

    Article  PubMed  CAS  Google Scholar 

  • Johnstone EC et al. (1976) Cerebral ventricual size and cognitive impairment in chronic schizophrenia. Lancet II: 924–926

    Article  Google Scholar 

  • Kegeles LS et al. (2000) Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol Psychiatry 48(7): 627–640

    Article  PubMed  CAS  Google Scholar 

  • Kovalenko S et al. (2003) Regio entorhinalis in schizophrenia: more evidence for migrational disturbances and suggestions for a new biological hypothesis. Pharmacopsychiatry 36(Suppl 3): S158–S161

    PubMed  Google Scholar 

  • Lawrie SM, Abukmeil SS (1998) Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 172: 110–120

    Article  PubMed  CAS  Google Scholar 

  • Maier W (1999) Genetics of schizophrenic disorders. New concepts and findings. Nervenarzt 70(11): 955–969

    Article  PubMed  CAS  Google Scholar 

  • Marenco S, Weinberger DR (2000) The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 12(3): 501–527

    Article  PubMed  CAS  Google Scholar 

  • Michailov GV, Sereda MW, Brinkmann BG et al. (2004) Axonal neuregulin-1 regulates myelin sheath thickness. Science 304(5671): 700–703

    Article  PubMed  CAS  Google Scholar 

  • Peters G (1967) Neuropathologie und Psychiatrie. In: Gruhle HW (Hrsg) Psychiatrie der Gegenwart, Bd 1. Springer, Berlin Heidelberg New York Tokio, S 298–305

    Google Scholar 

  • Reif A et al. (2006) A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function. Mol Psychiatry 11(3): 286–300

    Article  PubMed  CAS  Google Scholar 

  • Sawada K et al. (2005) Hippocampal complexin proteins and cognitive dysfunction in schizophrenia. Arch Gen Psychiatry 62(3): 263–272

    Article  PubMed  CAS  Google Scholar 

  • Scherk H, Falkai P (2006) Effects of antipsychotics on brain structure. Curr Opin Psychiatry 19(2): 145–150

    Article  PubMed  Google Scholar 

  • Selemon LD et al. (1998) Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method. J Comp Neurol 392(3): 402–412

    Article  PubMed  CAS  Google Scholar 

  • Shields J, Gottesman II (1977) Obstetric complications and twin studies of schizophrenia: clarifications and affirmations. Schizophr Bull 3(3): 351–354

    PubMed  CAS  Google Scholar 

  • Steen RG et al. (2006) Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 188: 510–518

    Article  PubMed  Google Scholar 

  • Toro CT, Deakin JFW (2007) Adult neurogenesis and schizophrenia: a window on abnormal early brain development? Schizophr Res 90(1–3): 1–14

    Article  PubMed  CAS  Google Scholar 

  • Vogeley K et al. (2003) Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia. Schizophr Res 62(1–2): 133–140

    Article  PubMed  Google Scholar 

  • Walker EF et al. (1994) Neuromotor precursors of schizophrenia. Schizophr Bull 20(3): 441–451

    PubMed  CAS  Google Scholar 

  • Weinberger DR (1988) Schizophrenia and the frontal lobe. Trends Neurosci 11(8): 367–370

    Article  PubMed  CAS  Google Scholar 

  • Wright IC et al. (2000) Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157(1): 16–25

    PubMed  CAS  Google Scholar 

  • Zobel A, Maier W (2004) Endophenotype — a new concept for biological characterization of psychiatric disorders. Nervenarzt 75(3): 205–214

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Psychiatrie und Psychotherapie, Universität des Saarlandes, 66421, Homburg/Saar

    Peter Falkai (Prof. Dr. med.)

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  1. Peter Falkai
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© 2008 Springer Medizin Verlag Heidelberg

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Falkai, P. (2008). Diagnose, Ätiologie und Neuropathophysiologie der Schizophrenie. In: Neuropsychologie der Schizophrenie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71147-6_4

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  • DOI: https://doi.org/10.1007/978-3-540-71147-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71146-9

  • Online ISBN: 978-3-540-71147-6

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