Auszug
Störungen in der Sprachverarbeitung finden sich bei Patienten mit Schizophrenie in ihrer ausgeprägtesten Form klinisch als „Konkretismus“, d. h. als Festhalten an der wörtlichen Bedeutung übertragener Begriffe („Der Apfel fällt nicht weit vom Stamm“). In leichter Ausprägung — d. h. in Form von Problemen beim Verstehen von sprachlichen Ausdrücken — findet sich dieses Phänomen bei fast allen Patienten; es gilt als einer der wichtigsten Prädiktoren für das Auftreten einer Psychose im Prodromalstadium.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Beeman MJ, Friedman RB, Grafman J, Perez E, Diamond S, Lindsay MB (1994) Summation priming and coarse semantic coding in the right hemisphere. J Cognit Neurosci 6 26–45
Friederici AD (2002) Towards a neural basis of auditory sentence processing. Trends Cogn Sci 6: 78–84
Hazlett EA, Buchsbaum MS, Jeu LA, Nenadic I, Fleischman MB, Shihabuddin L et al. (2000) Hypofrontality in unmedicated schizophrenia patients studied with PET during performance of a serial verbal learning task. Schizophr Res 43: 33–46
Iakimova G, Passerieux C, Laurent JP, Hardy-Bayle MC (2005) ERPs of metaphoric, literal, and incongruous semantic processing in schizophrenia. Psychophysiology 42: 380–390
Kasai K, Shenton ME, Salisbury DF et al. (2003a) Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in firste-pisode schizophrenia: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry 60: 766–775
Kasai K, Yamada H, Kamio S et al. (2003b) Neuromagnetic correlates of impaired automatic categorical perception of speech sounds in schizophrenia. Schizophr Res 59: 159–172
Kircher TTJ, Bulimore ET, Brammer MJ et al. (2001) Differential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder. Schizophr Res 50: 27–40
Kircher TTJ, Leube DT, Erb M, Grodd W, Rapp AM (2007). Neural correlates of metaphor processing in schizophrenia. Neuroimage 34: 281–289
Kostova M, Passerieux C, Laurent JP, Hardy B (2005) N400 anomalies in schizophrenia are correlated with the severity of formal thought disorder. Schizophr Res 78: 285–291
Kostova M, Passerieux C, Laurent JP, Saint-Georges C, Hardy-Bayle MC (2003) Functional analysis of the deficit in semantic context processes in schizophrenic patients: an event-related potentials study. Clin Neurophysiol 33: 11–22
Kubicki M, McCarley RW, Nestor PG et al. (2003) An fMRI study of semantic processing in men with schizophrenia. Neuroimage 20: 1923–1933
Kumar N, Debruille JB (2004) Semantics and N400: insights in schizophrenia. J Psychiatry Neurosci 29: 89–98
Kuperberg GR, Deckersbach T, Holt D, Goff D, West WC (2007). Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Arch Gen Psychiatry 64: 138–151
Kuperberg GR, Sitnikova T, Goff D, Holcomb PJ (2006) Making sense of sentences in schizophrenia: electrophysiological evidence for abnormal interactions between semantic and syntactic processing. J Abnorm Psychol 115: 251–265
McDonald B, Highley JR, Walker MA et al. (2000) Anomalous asymmetry of fusiform and parahippocampal gyrus gray matter in schizophrenia: a postmortem study. Am J Psychiatry 157: 40–47
Mitchell RL, Elliott R, Barry M, Cruttenden A, Woodruff PW (2004) Neural response to emotional prosody in schizophrenia and in bipolar affective disorder. Br J Psychiatry 184: 223–230
Ngan ET, Vouloumanos A, Cairo TA et al. (2003) Abnormal processing of speech during oddball target detection in schizophrenia. Neuroimage 20: 889–897
Niznikiewcz MA, O’Donnell BF, Nestor PG et al. (1997) ERP assessment of visual and auditory language processing in schizophrenia. J Abnorm Psychol 106: 85–94
Pantelis C, Velakoulis D, McGorry PD et al. (2003) Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361: 281–288
Plaze M, Bartres-Faz D, Martinot JL et al. (2006) Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients. Schizophr Res 87: 109–115
Ragland JD, Gur RC, Valdez JN et al. (2005) Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition. Am J Psychiatry 162: 1840–1848
Ragland JD, Gur RC, Valdez J et al. (2004) Event-related fMRI of fronto-temporal activity during word encoding and recognition in schizophrenia. Am J Psychiatry 161: 1004–1015
Rapp AM, Leube DT, Erb M, Grodd W, Kircher TT (2004) Neural correlates of metaphor processing. Brain Res Cogn Brain Res 20: 395–402
Ruchsow M, Trippel N, Groen G, Spitzer M, Kiefer M (2003) Semantic and syntactic processes during sentence comprehension in patients with schizophrenia: evidence from event-related potentials. Schizophr Res 64: 147–156
Salisbury DF, O’Donnell BF, McCarley RW, Nestor PG, Shenton ME (2000) Event-related potentials elicited during a context-free homograph task in normal versus schizophrenic subjects. Psychophysiology 37: 456–463
Shenton ME, Kikinis R, Jolesz FA et al. (1992) Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med 327: 604–612
Shenton ME, Dickey CC, Frumin M, McCarley RW (2001) A review of MRI findings in schizophrenia. Schizophr Res 49: 1–52
Sommer I, Ramsey N, Kahn R, Aleman A, Bouma A (2001) Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. Br J Psychiatry 178: 344–351
Sommer IEC, Ramsey NF, Mandl RCW, Kahn RS (2003) Language lateralization in female patients with schizophrenia: an fMRI study. Schizophr Res 60: 183–190
Sommer IEC, Ramsey NF, Mandl RCW, Van Oel CJ, Kahn RS (2004) Language activation in monozygotic twins discordant for schizophrenia. Br J Psychiatry 184: 128–135
Strandburg RJ, Marsh JT, Brown WS et al. (1997) Event-related potential correlates of linguistic information processing in schizophrenics. Biol Psychiatry 42: 596–608
Surguladze SA, Calvert GA, Brammer MJ et al. (2001) Audio-visual speech perception in schizophrenia: an fMRI study. Psychiatry Res 106: 1–14
Taylor JL, Blanton RE, Levitt JG, Caplan R, Nobel D, Toga AW (2005) Superior temporal gyrus differences in childhood-onset schizophrenia. Schizophr Res 73: 235–241
Tendolkar I, Weis S, Guddat O et al. (2004) Evidence for a dysfunctional retrosplenial cortex in patients with schizophrenia: a functional magnetic resonance imaging study with a semantic-perceptual contrast. Neurosci Lett 369: 4–8
Weinstein S, Werker JF, Vouloumanos A, Woodward TS, Ngan ETC (2006) Do you hear what I hear? Neural correlates of thought disorder during listening to speech in schizophrenia. Schizophr Res 86: 130–137
Whalley HC, Simonotto E, Marshall I et al. (2005) Functional disconnectivity in subjects at high genetic risk of schizophrenia. Brain, 128: 2097–2108
Woodruff PW, Wright IC, Bullmore ET et al. (1997) Auditory hallucinations and the temporal cortical response to speech in schizophrenia: a functional magnetic resonance imaging study. Am J Psychiatry 154: 1676–1682
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Green, A., Straube, B., Kircher, T. (2008). Sprachverständnis — Bildgebung. In: Neuropsychologie der Schizophrenie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71147-6_26
Download citation
DOI: https://doi.org/10.1007/978-3-540-71147-6_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-71146-9
Online ISBN: 978-3-540-71147-6
eBook Packages: Medicine (German Language)