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Nuclear Export of Proteins and RNA

  • Chapter
Functional Organization of the Plant Nucleus

Part of the book series: Plant Cell Monographs ((CELLMONO,volume 14))

Abstract

Several nuclear export receptors that facilitate the export of proteins and small RNAs from the nucleus to the cytoplasm have been functionally characterized in Arabidopsis thaliana in the past few years. With the specific cargo molecules they transport, the export receptors supply the cytoplasm with information, resulting in changes in cellular events. In this way, nuclear export receptors contribute to signal transduction that is highlighted in mutants with impaired export activity. In addition, nuclear export of proteins is part of a control layer for gene expression that is unique to eukaryotes, namely nucleocytoplasmic partitioning of regulatory proteins. This is revealed by growing evidence for shuttling proteins that participate in different signaling cascades, including phytohormone signaling. Although a plant mRNA export receptor is still missing in plants, several genes encoding protein factors that function in mRNA export to the cytoplasm were characterized by their mutant phenotypes. These findings show that cold, stress, or phytohormone signaling cascades and the control of flowering are especially sensitive to impaired mRNA biogenesis and export.

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References

  • Bai MY, Zhang LY, Gampala SS, Zhu SW, Song WY, Chong K, Wang ZY (2007) Functions of OsBZR1 and 14-3-3 proteins in brassinosteroid signaling in rice . Proc Natl Acad Sci USA 104:13839–13844

    Article  PubMed  CAS  Google Scholar 

  • Belostotsky BA (2003) Unexpected complexity of poly(A) binding protein gene families in flowering plants: three conserved lineages that are at least 200 million years old and possible auto-and cross-regulation. Genetics 163:311–319

    PubMed  CAS  Google Scholar 

  • Bezerra IC, Michaels SD, Schomburg FM, Amasino RM (2004) Lesions in the mRNA cap-binding gene ABA HYPERSENSITIVE 1 suppress FRIGIDA-mediated delayed flowering in Arabidopsis. Plant J 40:112–119

    Article  PubMed  CAS  Google Scholar 

  • Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J 21:6205–6215

    Article  PubMed  CAS  Google Scholar 

  • Bohnsack MT, Czaplinski K, Gorlich D (2004) Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10:185–191

    Article  PubMed  CAS  Google Scholar 

  • Bollman KM , Aukerman MJ , Park M-Y , Hunter C , Berardini TZ , Poethig RS (2003) HASTY, the Arabidopsis orthologs of exportin 5/MSN5, regulates phase change and morphogenesis . Development 130:1493–1504

    Article  PubMed  CAS  Google Scholar 

  • Bravo J, Aguilar-Henonin L, Olmedo G, Guzmán P (2005) Four distinct classes of proteins as interaction partners of the PABC domain of Arabidopsis thaliana poly(A)-binding proteins. Mol Genet Genomics 272:651–665

    Article  PubMed  CAS  Google Scholar 

  • Calado A, Treichel N, Müller E-C, Otto A, Kutay U (2002) Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J 21:6216–6224

    Article  PubMed  CAS  Google Scholar 

  • Carvalho MF, Turgeon R, Lazarowitz SG (2006) The geminivirus nuclear shuttle protein NSP inhibits the activity of AtNSI, a vascular-expressed Arabidopsis acetyltransferase reglated with the sink-to-source transition. Plant Physiol 140:1317–1330

    Article  PubMed  CAS  Google Scholar 

  • Chekanova JA, Belostotsky DA (2003) Evidence that poly(A) binding protein has an evolutionar-ily conserved function in facilitating mRNA biogenesis and export. RNA 9:1476–1490

    Article  PubMed  CAS  Google Scholar 

  • Chekanova JA, Shaw RJ, Belostotsky DA (2001) Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation . Curr Biol 11:1207–1214

    Article  PubMed  CAS  Google Scholar 

  • Cole CN, Scarcelli JJ (2006) Transport of messenger RNA from the nucleus to the cytoplasm. Curr Opin Cell Biol 18:299–306

    Article  PubMed  CAS  Google Scholar 

  • Comella P, Pontvianne F, Lahmy S, Vignols F, Barbezier N, DeBures A, Jobet E, Brugidou E, Echeverria M, Saez-Vasquez J (2007) Characterization of a ribonuclease III-like protein required for the cleavage of the pre-rRNA in the 3 ETS in Arabidopsis. Nucleic Acids Res 36:1163–1175

    Article  PubMed  CAS  Google Scholar 

  • Conti E, Izaurralde E (2001) Nucleocytoplasmic transport enters the atomic age. Curr Opin Cell Biol 13:310–319

    Article  PubMed  CAS  Google Scholar 

  • Cullen BR (2003) Nuclear RNA export. J Cell Sci 116:587–597

    Article  PubMed  Google Scholar 

  • Dahlberg JE, Lund E (2004) Does protein synthesis occur in the nucleus? Curr Opin Cell Biol 16:335–338

    Article  PubMed  CAS  Google Scholar 

  • Dong A, Liu Z, Yu F, Li Z, Cao K, Shen WH (2005) Interacting proteins and differences in nuclear transport reveal specific functions for the NAP1 family proteins in plants . Plant Physiol 138:1446–1456

    Article  PubMed  CAS  Google Scholar 

  • Dong CH, Hu X, Tang W, Zheng X, Kim YS, Lee BH, Zhu JK (2006) A putative Arabidopsis nucleoporin, AtNUP160, is critical for RNA export and required for plant tolerance to cold stress. Mol Cell Biol 26:9533–9543

    Article  PubMed  CAS  Google Scholar 

  • Fribourg S, Braun IC, Izaurralde E, Conti E (2001) Structural basis for the recognition of a nucle-oporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export receptor . Mol Cell 8:645–656

    Article  PubMed  CAS  Google Scholar 

  • Gampala SS, Kim TW, He JX, Tang W, Deng Z, Bai MY, Guan S, Lalonde S, Sun Y, Gendron JM, Chen H, Shibagaki N, Ferl RJ, Ehrhardt D, Chong K, Burlingame AL, Wang ZY (2007) An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell 13:177–89

    Article  PubMed  CAS  Google Scholar 

  • Gong Z, Lee H, Xiong L, Jagendorf A, Stevenson B, Zhu JK (2002) RNA helicase-like protein as an early regulator of transcription factors for plant chilling and freezing tolerance . Proc Natl Acad Sci USA 99:11507–11512

    Article  PubMed  CAS  Google Scholar 

  • Gong Z, Dong CH, Lee H, Zhu J, Xiong L, Gong D, Stevenson B, Zhu JK (2005) A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis. Plant Cell 17:256–267

    Article  PubMed  CAS  Google Scholar 

  • Görlich D, Kutay U (1999) Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Biol 15:607–660

    Article  Google Scholar 

  • Grasser M, Lentz A, Lichota J, Merkle T , Grasser KD (2006) The Arabidopsis genome encodes structurally and functionally diverse HMGB-type proteins. J Mol Biol 358:654–664

    Article  PubMed  CAS  Google Scholar 

  • Grosshans H, Deinert K, Hurt E, Simos G (2001) Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleus, assembly with the SRP-RNA, and Xpo1p-mediated export. J Cell Biol 153:745–762

    Article  PubMed  CAS  Google Scholar 

  • Gwizdek C, Ossareh-Nazari B, Brownawell AM, Doglio A, Bertrand E, Macara IG, Dargemont C (2003) Exportin-5 mediates nuclear export of minihelix-containing RNAs. J Biol Chem 278:5505–5508

    Article  PubMed  CAS  Google Scholar 

  • Gwizdek C, Ossareh-Nazari B, Brownawell AM, Evers S, Macara IG, Dargemont C (2004) Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. J Biol Chem 279:884–891

    Article  PubMed  CAS  Google Scholar 

  • Haasen D, Köhler C, Neuhaus G, Merkle T (1999) Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana. Plant J 20:695–705

    Article  PubMed  CAS  Google Scholar 

  • Haasen D, Merkle T (2002) Characterization of an Arabidopsis homologue of the nuclear export receptor CAS by its interaction with Importin alpha. Plant Biol 4:432–439

    Article  CAS  Google Scholar 

  • Heerklotz D, Döring P, Bonzelius F, Winkelhaus S, Nover L (2001) The balance of nuclear import and export determines the intracellular distribution and function of tomato heat stress trasn-cription factor HsfA2. Mol Cell Biol 21:1759–1768

    Article  PubMed  CAS  Google Scholar 

  • Hernandez-Pinzon I, Yelina NE, Schwach F, Studholme DJ, Baulcombe D, Dalmay T (2007) SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA. Plant J 50:140–148

    Article  PubMed  CAS  Google Scholar 

  • Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (2000) TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol Cell Biol 20:8996–9008

    Article  PubMed  CAS  Google Scholar 

  • Hood JK, Silver PA (1998) Cse1p is required for export of Srp1p/importin-a from the nucleus in Saccharomyces cerevisiae. J Biol Chem 273:35142–35146

    Article  PubMed  CAS  Google Scholar 

  • Hugouvieux V, Murata Y, Young JJ, Kwak JM, Mackesy DZ, Schroeder JI (2002) Localization, ion channel regulation, and genetic interactions during abscisic acid signaling of the nuclear mRNA cap-binding protein, ABH1. Plant Physiol 130:1276–1287

    Article  PubMed  CAS  Google Scholar 

  • Hunter CA, Aukerman MJ, Sun H, Fokina M, Poethig RS (2003) PAUSED encodes the Arabidopsis Exportin-t orthologs. Plant Physiol 132:2135–2143

    Article  PubMed  CAS  Google Scholar 

  • Igarashi D, Ishida S, Fukazawa J, Takahashi Y (2001) 14-3-3 proteins regulate intracellular localization of the bZIP transcriptional activator RSG. Plant Cell 13:2483–2497

    Article  PubMed  CAS  Google Scholar 

  • Ishida S, Fukazawa J, Yuasa T, Takahashi Y (2004) Involvement of 14-3-3 signaling protein binding in the functional regulation of the transcriptional activator REPRESSION OF SHOOT GROWTH by gibberellins. Plant Cell 16:2641–2651

    Article  PubMed  CAS  Google Scholar 

  • Izaurralde E, Kutay U, von Kobbe C, Mattaj IW, Görlich D (1997) The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus . EMBO J 16:6535–6547

    Article  PubMed  CAS  Google Scholar 

  • Jacob Y, Mongkolsiriwatana C, Veley KM, Kim SY, Michaels SD (2007) The nuclear pore protein AtTPR is required for RNA homeostasis, flowering time, and auxin signaling . Plant Physiol. 144:1383–1890

    Article  PubMed  CAS  Google Scholar 

  • Jacoby MJ, Weinl C, Pusch S, Kuijt SJH, Merkle T, Dissmeyer N, Schnittger A (2006) Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1. Plant Physiol 141:1293–1305

    Article  CAS  Google Scholar 

  • Jiang CJ, Imamoto N, Matsuki R, Yoneda Y, Yamamoto N (1998) In vitro characterization of rice importin beta 1: molecular interaction with nuclear transport factors and mediation of nuclear protein import. FEBS Lett 437:127–130

    Article  PubMed  CAS  Google Scholar 

  • Johnson AW, Lund E, Dahlberg J (2002) Nuclear export of ribosomal subunits. Trends Biochem Sci 27:580–585

    Article  PubMed  CAS  Google Scholar 

  • Jones-Rhoades MW, Bartel DP, Bartel B (2006) MicroRNAs and their regulatory roles in plants. Annu Rev Plant Biol 57:19–53

    Article  PubMed  CAS  Google Scholar 

  • Kaffman A, O'Shea EK (1999) Regulation of nuclear localisation: a key to a door. Annu Rev Cell Dev Biol 15:291–339

    Article  PubMed  CAS  Google Scholar 

  • Kaminaka H, Näke C, Epple P, Dittgen J, Schütze K, Chaban C, Holt III BF, Merkle T, Schäfer E,Harter K, Dangl JL (2006) bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. EMBO J 25:4400–4411

    Article  PubMed  CAS  Google Scholar 

  • Katahira J, Straesser K, Saiwaki T, Yoneda Y, Hurt E (2002) Complex formation between TAP and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling . J Biol Chem 277:9242–9246

    Article  PubMed  CAS  Google Scholar 

  • Kmieciak M, Simpson CG, Lewandowska D, Brown JW, Jarmolowski A (2002) Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex. Gene 283:171–183

    PubMed  CAS  Google Scholar 

  • Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, Yoshida M, Horinouchi S (1999) Leptomycin B inactivates CRM1/Exportin 1 by covalent modification at a cysteine residue in the conserved central region. Proc Natl Acad Sci USA 96:9112–9117

    Article  PubMed  CAS  Google Scholar 

  • Künzler M, Hurt EC (1998) Cse1p functions as the nuclear export receptor for importin a in yeast. FEBS Lett 433:185–190

    Article  PubMed  Google Scholar 

  • Kutay U, Bischoff FR, Kostka S, Kraft R, Görlich D (1997) Export of importin a from the nucleus is mediated by a specific nuclear transport factor. Cell 90:1061–1071

    Article  PubMed  CAS  Google Scholar 

  • Levesque L, Bor Y-C, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld M-L, Paschal MB (2006) Mutations in TAP uncouple RNA export activity from translocation through the nuclear pore complex. Mol Biol Cell 17:931–943

    Article  PubMed  CAS  Google Scholar 

  • Li J, Chen X (2003) PAUSED, a putative Exportin-t, acts pleiotropically in Arabidopsis development but is dispensable for viability. Plant Physiol 132:1913–1924

    Article  PubMed  CAS  Google Scholar 

  • Link D, Schmidlin L, Schirmer A, Klein E, Erhardt M, Geldreich A, Lemaire O, Gilmer D (2005) Functional characterization of the beet necrotic yellow vein virus RNA-5-encoded p26 protein: evidence for structural pathogenicity determinants. J Gen Virol 86:2115–2125

    Article  PubMed  CAS  Google Scholar 

  • Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Görlich D (2000) Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes . EMBO J 19:4362–4371

    Article  PubMed  CAS  Google Scholar 

  • Lund E, Güttinger S, Calado A, Dahlberg JE, Kutay U (2004) Nuclear export of microRNA precursors. Science 303:95–98

    Article  PubMed  CAS  Google Scholar 

  • Mallory AC, Reinhart BJ, Jones-Rhoades MW, Tang G, Zamore PD, Barton MK, Bartel DP (2004) MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5 region. EMBO J 23:3356–3364

    Article  PubMed  CAS  Google Scholar 

  • Martini J, Schmied K, Palmisano R, Toensing K, Anselmetti D, Merkle T (2007) Multifocal two-photon laser scanning microscopy combined with photo-activatable GFP for in vivo monitoring intracellular protein dynamics in real time. J Struct Biol 158:401–409

    Article  PubMed  CAS  Google Scholar 

  • Merkle T (2001) Nuclear import and export of proteins in plants: a tool for the regulation of signalling. Planta 213:499–517

    Article  PubMed  CAS  Google Scholar 

  • Merkle T (2003) Nucleo-cytoplasmic partitioning in plants: implications for the regulation of environmental and developmental signaling. Curr Genet 44:231–260

    Article  PubMed  CAS  Google Scholar 

  • Mingot J-M, Kostka S, Kraft R, Hartmann E, Görlich D (2001) Importin 13: a novel mediator of nuclear import and nuclear export. EMBO J 20:3685–3694

    Article  PubMed  CAS  Google Scholar 

  • Mingot J-M, Bohnsack MT, Jäckle U, Görlich D (2004) Exportin 7 defines a novel general nuclear export pathway. EMBO J 23:3227–3236

    Article  PubMed  CAS  Google Scholar 

  • Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW (2000) PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell 101:187–198

    Article  PubMed  CAS  Google Scholar 

  • Papp I, Mette MF, Aufsatz W, Daxinger L, Schauer SE, Ray A, van der Winden J, Matzke M, Matzke AJM (2003) Evidence for nuclear processing of plant micro RNA and short interfering RNA precursors. Plant Phys 132:1382–1390

    Article  CAS  Google Scholar 

  • Papp I, Mur LA, Dalmadi A, Dulai S, Koncz C (2004) A mutation in the cap binding protein 20 gene confers drought tolerance to Arabidopsis. Plant Mol Biol. 5(5):679–686

    Article  Google Scholar 

  • Paraskeva E, Izaurralde E, Bischoff FR, Huber J, Kutay U, Hartmann E, Lührmann R, Görlich D (1999) CRM1-mediated recycling of snurportin 1 to the cytoplasm. J Cell Biol 145:255–264

    Article  PubMed  CAS  Google Scholar 

  • Park M-Y, Wu G, Gonzalez-Sulser A, Vaucheret H, Poethig RS (2005) Nuclear processing and export of microRNAs in Arabidopsis. Proc Natl Acad Sci USA 102:3691–3696

    Article  PubMed  CAS  Google Scholar 

  • Parry G, Ward S, Cernac A, Dharmasiri S, Estelle M (2006) The Arabidopsis SUPPRESSOR OF AUXIN RESISTANCE proteins are nucleoporins with an important role in hormone signaling and development. Plant Cell 18:1590–1603

    Google Scholar 

  • Pay A, Resch K, Frohnmeyer H, Fejes E, Nagy F, Nick P (2002) Plant RanGAPs are localised at the nuclear envelope in interphase and associated with microtubules in mitotic cells . Plant J 30:699–709

    Article  PubMed  CAS  Google Scholar 

  • Pemberton LF, Paschal BM (2005) Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic 6:187–198

    Article  PubMed  CAS  Google Scholar 

  • Pendle AF, Clark GP, Boon R, Lewandowska D, Lam YW, Andersen J, Mann M, Lamond AI,Brown JWS, Shaw PJ (2005) Poteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Mol Biol Cell 16:260–269

    Article  PubMed  CAS  Google Scholar 

  • Poon IKH, Jans DA (2005) Regulation of nuclear transport: central role in development and transformation? Traffic 6:173–186

    Article  PubMed  CAS  Google Scholar 

  • Razem FA, El-Kereamy A, Abrams SR, Hill RD (2006) The RNA-binding protein FCA is an abscisic acid receptor. Nature 439:290–294

    Article  PubMed  CAS  Google Scholar 

  • Ribbeck K, Lipowsky G, Kent HM, Stewart M, Görlich D (1998) NTF2 mediates nuclear import of Ran. EMBO J 17:6587–6598

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez MS, Dargemont C, Stutz F (2004) Nuclear export of RNA. Biol Cell 96:639–655

    Article  PubMed  CAS  Google Scholar 

  • Ryu H, Kim K, Cho H, Park J, Choe S, Hwang I (2007) Nucleocytoplasmic shuttling of BZR1 mediated by phosphorylation is essential in Arabidopsis brassinosteroid signaling. Plant Cell 19:2749–2762

    Article  PubMed  CAS  Google Scholar 

  • Smith A, Brownawell A, Macara IG (1998) Nuclear import of Ran is mediated by the transport factor NTF2. Curr Biol 8:1403–1406

    Article  PubMed  CAS  Google Scholar 

  • Solsbacher J, Maurer P, Bischoff FR, Schlenstedt G (1998) Cse1p is involved in export of yeast importin a from the nucleus. Mol Cell Biol 18:6805–6815

    PubMed  CAS  Google Scholar 

  • Stewart M (2007) Ratcheting mRNA out of the nucleus. Mol Cell 25:327–330

    Article  PubMed  CAS  Google Scholar 

  • Stutz F, Izaurralde E (2003) The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol 13:319–327

    Article  PubMed  CAS  Google Scholar 

  • Stutz F, Bachi A, Doerks T, Braun IC, Seraphin B, Wilm M, Bork P, Izaurralde E (2000) REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA export. RNA 6:638–650

    Article  PubMed  CAS  Google Scholar 

  • Stüven T, Hartmann E, Görlich D (2003) Exportin 6: a novel nuclear export receptor that is specific for profilin-actin complexes. EMBO J 22:5928–5940

    Article  PubMed  Google Scholar 

  • Suo Y, Miernyk JA (2004) Regulation of nucleocytoplasmic localization of the AtDjC6 chaperone protein. Protoplasma 224:79–89

    PubMed  CAS  Google Scholar 

  • Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E, Bork P (2000) Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins . EMBO Rep1:53–58

    Article  PubMed  CAS  Google Scholar 

  • Telfer A, Poethig RS (1998) HASTY : a gene that regulates the timing of shoot maturation in Arabidopsis thaliana. Development 125:1889–1898

    PubMed  CAS  Google Scholar 

  • Thomas F, Kutay U (2003) Biogenesis and nuclear export of ribosomal subunits in higher eukary-otes depend on the CRM1 export pathway. J Cell Sci 116:2409–2419

    Article  PubMed  CAS  Google Scholar 

  • Tillemans V, Leponce I, Rausin G, Dispa L, Motte P (2006) Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors. Plant Cell 18:3218–3234

    Article  PubMed  CAS  Google Scholar 

  • Turpin P, Ossareh-Nazari B, Dargemont C (1999) Nuclear transport and transcriptional regulation.FEBS Lett 452:82–86

    Article  PubMed  CAS  Google Scholar 

  • Uhrig JF, Canto T, Marshall D, MacFarlane SA (2004) Relocalization of nuclear ALY proteins to the cytoplasm by the tomato Bushy stunt virus p19 pathogenicity protein . Plant Phys 135:2411–2423

    Article  CAS  Google Scholar 

  • Van de Peer Y, De Wachter R (1997) Construction of evolutionary distance trees with TREECON for Windows: accounting for variation in nucleotide substitution rate among sites . Comput Appl Biosci 13:227–230

    PubMed  Google Scholar 

  • Vetter G, Hily J-M, Klein E, Schmidlin L, Haas M, Merkle T, Gilmer D (2004) Nucleo-cytoplasmic shuttling of the beet necrotic yellow vein virus RNA-3-encoded p25 protein . J Gen Virol 85:2459–2469

    Article  PubMed  CAS  Google Scholar 

  • Vinciguerra P, Stutz F (2004) mRNA export: an assembly line from genes to nuclear pores. Curr Opin Cell Biol 16:285–292

    Article  PubMed  CAS  Google Scholar 

  • Weis K (2003) Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112:441–451

    Article  PubMed  CAS  Google Scholar 

  • Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, Cullen BR (2002) Formation of TAP/ NXT1 heterodimers activates TAP-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol Cell Biol 22:245–256

    Article  PubMed  CAS  Google Scholar 

  • Xie Z, Kasschau KD, Carrington JC (2003) Negative feedback regulation of Dicer-Like1 in Arabidopsis by microRNA-guided mRNA degradation. Curr Biol 13:784–789

    Article  PubMed  CAS  Google Scholar 

  • Xu XM, Meier I (2008) The nuclear pore comes to the fore. Trends Plant Sci 13:20–27

    Article  PubMed  CAS  Google Scholar 

  • Xu XM, Rose A, Muthuswamy S, Jeong SY, Venkatakrishnan S, Zhao Q, Meier I (2007) NUCLEAR PORE ANCHOR, the Arabidopsis homolog of Tpr/Mlp1/Mlp2/megator, is involved in mRNA export and SUMO homeostasis and affects diverse aspects of plant development. Plant Cell 19:1537–1548

    Article  PubMed  CAS  Google Scholar 

  • Yao W, Roser D, Köhler A, Bradatsch B, Baβler J, Hurt E (2007) Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2. Mol Cell 26:51–62

    Article  PubMed  CAS  Google Scholar 

  • Yi R, Qin Y, Macara IG, Cullen BR (2003) Exportin-5 mediates the nuclear export of pre-micro-RNAs and short hairpin RNAs. Genes Dev 17:3011–3016

    Article  PubMed  CAS  Google Scholar 

  • Zeidler M, Zhou Q, Sarda X, Yau CP, Chua NH (2004) The nuclear localization signal and the C-terminal region of FHY1 are required for transmission of phytochrome A signals . Plant J 40:355–365

    Article  PubMed  CAS  Google Scholar 

  • Zemp I, Kutay U (2007) Nuclear export and cytoplasmic maturation of ribosomal subunits. FEBS Lett 581:2783–2793

    Article  PubMed  CAS  Google Scholar 

  • Zhao Q, Leung S, Corbett AH, Meier I (2006) Identification and characterization of the Arabidopsis orthologs of Nuclear Transport Factor 2, the nuclear import factor of Ran . Plant Phys 140:869–878

    Article  CAS  Google Scholar 

  • Zhao J, Zhang W, Zhao Y, Gong X, Guo L, Zhu G, Wang X, Gong Z, Schumaker KS, Guo Y (2007) SAD2, an importin-like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking. Plant Cell 19:3805–3818

    Article  PubMed  CAS  Google Scholar 

  • Ziemienowicz A, Haasen D, Staiger D, Merkle T (2003) Arabidopsis Transportin is the nuclear import receptor for the circadian clock-regulated RNA-binding protein AtGRP7 . Plant Mol Biol 53:201–212

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Genome Research and Systems Biology, Faculty of Biology III, University of Bielefeld, Bielefeld, 33594, Germany

    Thomas Merkle

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  1. Dept. of Plant Cellular and Molecular Biology, The Ohio State University, 520 Aronoff Laboratory, Columbus, OH, 43210, USA

    Iris Meier

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Merkle, T. (2009). Nuclear Export of Proteins and RNA. In: Meier, I. (eds) Functional Organization of the Plant Nucleus. Plant Cell Monographs, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71058-5_4

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