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Dendritic Cells pp 81–98Cite as

Dendritic Cells and their Potential Implication in Pathology and Treatment of Rheumatoid Arthritis

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 188))

Abstract

Dendritic cells (DC) are the professional antigen presenting cells that protect us against invading organisms. On the other hand, they uphold tolerance thereby avoiding the initiation of autoimmunity. In performing these contrasting but essential tasks DC are unique and divide these processes in time and space. It is often thought that a loss of separation of these tasks underlies the breakthrough of tolerance leading to autoimmune conditions such as rheumatoid arthritis. In this review, we will focus on the evidence which points towards the implication of DC in the inflammatory process observed in RA and in experimental models of arthritis. Finally, we will conclude on future programs exploiting the capacity of DC to cure conditions such as RA.

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Authors and Affiliations

  1. Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    M. H. Wenink, W. Han, R. E. M. Toes & T. R. D. J. Radstake

Authors
  1. M. H. Wenink
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  2. W. Han
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  3. R. E. M. Toes
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  4. T. R. D. J. Radstake
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Corresponding author

Correspondence to T. R. D. J. Radstake .

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Editors and Affiliations

  1. DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

    Giovanna Lombardi (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation) (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation)

  2. 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, SE1 1UL, United Kingdom

    Yanira Riffo-Vasquez (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division) (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division)

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© 2009 Springer-Verlag Berlin Heidelberg

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Wenink, M.H., Han, W., Toes, R.E.M., Radstake, T.R.D.J. (2009). Dendritic Cells and their Potential Implication in Pathology and Treatment of Rheumatoid Arthritis. In: Lombardi, G., Riffo-Vasquez, Y. (eds) Dendritic Cells. Handbook of Experimental Pharmacology, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71029-5_4

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