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Replication of and Protein Synthesis by TT Viruses

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TT Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 331))

Abstract

The host cells and the events in the cells during Torque teno (TT) virus infection are at present unknown. Replicating TT virus DNA has been detected in liver, in peripheral blood mononuclear cells (PBMC), and in bone marrow. By alternative splicing this small virus generates three mRNA species, from which by alternative translation initiation at least six proteins are produced. The functions of the proteins are not yet fully understood. However, functions associated with, e.g., DNA replication, immunomodulation, and apoptosis have been suggested to reside in the multifunctional proteins of anelloviruses.

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Author information

Authors and Affiliations

  1. Department of Virology , Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Finland, Finland

    L. Kakkola, K. Hedman & M. S”derlund-Venermo

  2. Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, USA

    J. Qiu

  3. Department of Molecular Microbiology and Immunology, University of Missouri-Columbia, USA

    D. Pintel

Authors
  1. L. Kakkola
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  2. K. Hedman
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  3. J. Qiu
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  4. D. Pintel
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  5. M. S”derlund-Venermo
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Corresponding authors

Correspondence to L. Kakkola , K. Hedman , J. Qiu , D. Pintel or M. S”derlund-Venermo .

Editor information

Editors and Affiliations

  1. Deutsches Krebsforschungszentrum Abt., Tumorvirus-Charakterisierung, Im Neuenheimer Feld 242, Heidelberg, 69120, Germany

    Ethel-Michele de Villiers

  2. Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Harald zur Hausen

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© 2009 Springer-Verlag Berlin Heidelberg

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Kakkola, L., Hedman, K., Qiu, J., Pintel, D., S”derlund-Venermo, M. (2009). Replication of and Protein Synthesis by TT Viruses. In: de Villiers, EM., Hausen, H.z. (eds) TT Viruses. Current Topics in Microbiology and Immunology, vol 331. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70972-5_4

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