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Emergence of Lyssaviruses in the Old World: The Case of Africa

  • L. H. Nel
  • C. E. Rupprecht
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 315)

Rabies has a long history of occurrence throughout Africa, spanning hundreds of years. At least four distinct Lyssavirus species persist throughout the continent, among carnivores, bats and other mammals. Rabies virus is the most cosmopolitan member, with primary reservoirs within dogs and mongoose, but other wildlife vectors are important in viral maintenance, such as jackals. Besides a prominent toll on humans and domestic animals, the disease has an underappreciated role in conservation biology, especially for such highly endangered fauna as African wild dogs and Ethiopian wolves. Both Duvenhage and Lagos bat viruses are adapted to bats, but their epidemiology, together with Mokola virus, is poorly understood. Significantly, less than ideal crossreactivity with modern biologicals used for veterinary and public health interventions is a major cause for concern among these emerging viral agents.

Keywords

Rabies Virus Human Rabies Lumpy Skin Disease Virus Ethiopian Wolf Rabies Outbreak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • L. H. Nel
    • 1
  • C. E. Rupprecht
    • 2
  1. 1.Department of Microbiology, Faculty of Natural and Agricultural SciencesUniversity of PretoriaPretoriaAustralia
  2. 2.Division of Viral and Rickettsial Diseases, Poxvirus and Rabies Branch, Rabies ProgramCenters for Disease Control and PreventionAtlantaUSA

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