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Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets ( Paguma larvata ), together with two other wildlife animals, sampled from a live animal market were infected with SARS-CoV or a closely related virus. Recently, horseshoe bats in the genus Rhinolophus have been identified as natural reservoir of SARS-like coronaviruses. Here, we review studies by different groups demonstrating that SARS-CoV succeeded in spillover from a wildlife reservoir (probably bats) to human population via an intermediate host(s) and that rapid virus evolution played a key role in the adaptation of SARS-CoVs in at least two nonreservoir species within a short period.

Keywords

Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome Nipah Virus Severe Acute Respiratory Syndrome Patient Severe Acute Respiratory Syndrome Outbreak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson RM, Fraser C, Ghani AC, Donnelly CA, Riley S, Ferguson NM, Leung GM, Lam TH, Hedley AJ (2004) Epidemiology, transmission dynamics and control of SARS: the 2002–2003 epidemic. Philos Trans R Soc Lond B 359:1091–1105.CrossRefGoogle Scholar
  2. Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T (2006) Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev 19:531–545.CrossRefPubMedGoogle Scholar
  3. Chen WJ, Yan MH, Yang L, Ding BL, He B, Wang YZ, Liu XL, Liu CH, Zhu H, You B, Huang SY, Zhang JG, Mu F, Xiang Z, Feng XL, Wen J, Fang JQ, Yu J, Yang HM, Wang J (2005) SARS-associated coronavirus transmitted from human to pig. Emerg Inf Dis 11:446–448.Google Scholar
  4. Childs JE (2004) Zoonotic viruses of wildlife: hither from yon. Arch Virol Suppl 18:1–11.PubMedGoogle Scholar
  5. The Chinese SARS Molecular Epidemiology Consortium (2004) Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science 303:1666–1669.CrossRefGoogle Scholar
  6. Chua KB, Bellini WJ, Rota PA, Harcourt BH, Tamin A, Lam SK, Ksiazek TG, Rollin PE, Zaki SR, Shieh WJ, Goldsmith CS, Gubler DJ, Roehrig JT, Eaton BT, Gould AR, Olson J, Field H, Daniels P, Ling AE, Peters CJ, Anderson LJ, Mahy BWJ (2000) Nipah virus: a recently emergent deadly paramyxovirus. Science 288:1432–1435.CrossRefPubMedGoogle Scholar
  7. Chua KB, Koh CL, Hooi PS, Wee KF, Khong JH, Chua BH, Chan YP, Lim ME, Lam SK (2002) Isolation of Nipah virus from Malaysian Island flying-foxes. Microbes Infect 4:145–151.CrossRefPubMedGoogle Scholar
  8. Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW (2003) Identification of a novel coronavirus in patients with sever acute respiratory syndrome. New Engl J Med 348:1967–1976.CrossRefPubMedGoogle Scholar
  9. Fouchier RA, Kuiken T, Schutten M, Van Amerongen G, Van Doornum GJ, van den Hoogen BG, Peiris M, Lim W, Stohr K, Osterhaus AD (2003) Aetiology: Koch’s postulates fulfilled for SARS virus. Nature 423:240.CrossRefPubMedGoogle Scholar
  10. Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YJ, Butt KM, Wong KL, Chan KW, Lim W, Shortridge KF, Yuen KY, Peiris JSM, Poon LLM (2003) Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 302:276–278.CrossRefPubMedGoogle Scholar
  11. Halpin K, Young PL, Field HE, Mackenzie JS (2000) Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J Gen Virol 81:1927–1932.PubMedGoogle Scholar
  12. Holmes KV, Lai MMC (2001) Coronaviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PRM (eds) Fields virology 4th edn., Vol. 1. Lippincott Williams & Wilkins, Philadelphia, pp 1075–1094.Google Scholar
  13. Hudson PJ, RizzoliA, Grenfell BT, Heesterbeek H, Dobson AP (2002) The ecology of wildlife diseases. Oxford University Press, Oxford.Google Scholar
  14. Kan B, Wang M, Jing H, Xu H, Jiang X, Yan M, Liang W, Zheng H, Wan K, Liu Q, Cui B, Xu Y, Zhang E, Wang H, Ye J, Li G, Li M, Cui Z, Qi X, Chen K, Du L, Gao K, Zhao Y, Zou X, Feng Y, Gao Y, Hai R, Yu D, Guan Y, Xu J (2005) Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol 79:11892–11900.CrossRefPubMedGoogle Scholar
  15. Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ (2003) A novel coronavirus associated with severe acute respiratory syndrome. New Engl J Med 348:1953–1966.CrossRefPubMedGoogle Scholar
  16. Kuiken T, Fouchier RAM, Schutten M, Rimmelzwaan GF, van Amerongen G, van Riel D, Laman JD, de Jong T, van Doornum G, Lim W, Ling AE, Chan PKS, Tam JS, Zambon MC, Gopal R, Drosten C, van der Werf S, Escriou N, Manuguerra JC, Stohr K, Peiris JSM, Osterhaus ADME (2003) Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 362:263–270.CrossRefPubMedGoogle Scholar
  17. Lau SKP, Woo PCY, Li KSM, Huang Y, Tsoi HW, Wong BHL, Wong SSY, Leung SY, Chan KH, Yuen KY (2005) Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci U S A 102:14040–14045.CrossRefPubMedGoogle Scholar
  18. Leroy EM, Kumulungui B, Pourrut X, Rouquet P, Hassanin A, Yaba P, Delicat A, Paweska JT, Gonzalez JP, Swanepoel R (2005) Fruit bats as reservoirs of Ebola virus. Nature 438:575–576.CrossRefPubMedGoogle Scholar
  19. Li W, Moore MJ, Vasllieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greeneugh TC, Choe H, Farzan M (2003) Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426:450–454.CrossRefPubMedGoogle Scholar
  20. Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, Wang H, Crameri G, Hu Z, Zhang H, Zhang J, McEachern J, Field H, Daszak P, Eaton BT, Zhang S, Wang L-F (2005) Bats are natural reservoirs of SARS-like coronaviruses. Science 310:676–679.CrossRefPubMedGoogle Scholar
  21. Liang GD, Chen QX, Xu JG, Liu YF, Lim W, Peiris JSM, Anderson LJ, Ruan L, Li H, Kan B, Di B, Cheng P, Chan KH, Erdman DD, Gu SY, Yan XG, Liang WL, Zhou DH, Haynes L, Duan SM, Zhang X, Zheng H, Gao Y, Tong SX, Li DX, Fang L, Qin PZ, Xu WB, SARS Diagnosis Working Group (2005) Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province China. Emerg Infect Dis 10:1774–1781.Google Scholar
  22. Liang LC, He C, Lei M, Li SW, Hao YX, Zhu H, Duan Q (2005) Pathology of guinea pigs experimentally infected with a novel reovirus and coronavirus isolated from SARS patients. DNA Cell Biol 24:485–490.CrossRefPubMedGoogle Scholar
  23. Lu ZR, Qu LH (2004) Animal-to-human SARS-associated coronavirus transmission? Emerg Infect Dis 10:959.Google Scholar
  24. Marra MA, Jones SJM, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YSN, Khattra J, Asano JK, Barber SA, Chan SY, Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JF, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth T, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL (2003) The genome sequence of the SARS-associated coronavirus. Science 300:1399–1404.CrossRefPubMedGoogle Scholar
  25. Martina BEE, Haagmans BL, Kuiken T, Fouchier RAM, Rimmelzwaan GF, van Amerongen G, Peiris JSM, Lim W, Osterhaus ADME (2003) SARS virus infection of cats and ferrets. Nature 425:915.CrossRefPubMedGoogle Scholar
  26. Mickleburgh SP, Huston AM, Racey PA (2002) A review of the global conservation status of bats. Oryx 36:18–34.Google Scholar
  27. Murray K, Selleck P, Hooper P, Hyatt A, Gould A, Gleeson L, Westbury H, Hiley L, Selvey L, Rodwell B (1995) A morbillivirus that caused fatal disease in horses and humans. Science 268:94–97.CrossRefPubMedGoogle Scholar
  28. Ng SKC (2003) Possible role of an animal vector in the SARS outbreak in Amoy Gardens. Lancet 362:570–572.CrossRefPubMedGoogle Scholar
  29. Peiris JSM, GuanY, Yuen KY (2004) Severe acute respiratory syndrome. Nat Med 10:S88–S97.CrossRefGoogle Scholar
  30. Peiris JSM, Lai ST, Poon LLM, Guan Y, Yam LYC, Lim W, Nicholls J, Yee WKS, Yan WW, Cheung MT, Cheng VCC, Chan KH, Tsang DNC, Yung RWH, Ng TK, Yuen KY (2003) Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361:1319–1325.CrossRefPubMedGoogle Scholar
  31. Poon LLM, Chu DKW, Chan KH, Wong OK, Ellis TM, Leung YHC, Lau SKP, Woo PCY, Suen KY, Yuen KY, Guan Y, Peiris JSM (2005) Identification of a novel coronavirus in bats. J Virol 79:2001–2009.CrossRefPubMedGoogle Scholar
  32. Qin E, Zhu QY, Yu M, Fan BC, Chang GH, Si BY, Yang BA, Peng WM, Jiang T, Liu BH, Deng YQ, Liu H, Zhang Y, Wang C, Li YQ, Gan YH, Li XY, Lu FS, Tan G, Cao WC, Yang RF, Wang J, Li W, Xu ZY, Li Y, Wu QF, Lin W, Chen WJ, Tang L, Deng YF, Han YJ, Li CF, Lei M, Li GQ, Li WJ, Lu H, Shi JP, Tong ZZ, Zhang F, Li SG, Liu B, Liu SQ, Dong W, Wang J, Wong GKS, Yu J, Yang HM (2003) A complete sequence and comparative analysis of a SARS-associated virus (isolate BJ01). Chinese Sci Bull 48:941–948.CrossRefGoogle Scholar
  33. Roberts A, Paddock C, Vogel L, Butter E, Zaki S, Subbarao K (2005) Aged balb/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans. J Virol 79:5833–5838.CrossRefPubMedGoogle Scholar
  34. Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, Tong S, Tamin A, Lowe L, Frace M, Derisi JL, Chen Q, Wang D, Erdman DD, Peret TC, Burns C, Ksiazek TG, Rollin PE, Sanchez A, Liffick S, Holloway B, Limor J, McCaustland K, Olsen-Rasmussen M, Fouchier R, Gunther S, Osterhaus AD, Drosten C, Pallansch MA, Anderson LJ, Bellini WJ (2003) Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300:1394–1399.CrossRefPubMedGoogle Scholar
  35. Shen Z, Ning F, Zhou WG, He X, Lin CY, Chin DP, Zhu ZH, Schuchat A (2004) Superspreading SARS events Beijing, 2003. Emerg Infect Dis 10:256–260.PubMedGoogle Scholar
  36. Song HD, Tu CC, Zhang GW, Wang SY, Zheng K, Lei LC, Chen QX, Gao YW, Zhou HQ, Xiang H, Zheng HJ, Chern SWW, Cheng F, Pan CM, Xuan H, Chen SJ, Luo HM, Zhou DH, Liu YF, He JF, Qin PZ, Li LH, Ren YQ, Liang WJ, Yu YD, Anderson L, Wang M, Xu RH, Wu XW, Zheng HY, Chen JD, Liang GD, Gao Y, Liao M, Fang L, Jiang LY, Li H, Chen F, Di B, He LJ, Lin JY, Tong SX, Kong XG, Du L, Hao P, Tang H, Bernini A, Yu XJ, Spiga O, Guo ZM, Pan HY, He WZ, Manuguerra JC, Fontanet A, Danchin A, Niccolai N, Li YX, Wu CI, Zhao GP (2005) Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A 102:2430–2435.CrossRefPubMedGoogle Scholar
  37. Subbarao K, McAuliffe J, Vogel L, Fahle G, Fischer S, Tatti K, Packard M, Shieh WJ, Zaki S, Murphy B (2004) Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. J Virol 78:3572–3577.CrossRefPubMedGoogle Scholar
  38. Sulkin SE, Allen R (1974) Virus infections in bats. Karger, Basel.Google Scholar
  39. Swayne DE, Suarez DL, Spackman E, Tumpey TM, Beck JR, Erdman D, Rollin PE, Ksiazek TG (2004) Domestic poultry and SARS coronavirus, southern China. Emerg Infect Dis 10:914–916.PubMedGoogle Scholar
  40. Tsang KW, Ho PL, Ooi GC, Yee WK, Wang T, Chan-Yeung M, Lam WK, Seto WH, Yam LY, Cheung TM, Wong PC, Lam B, Ip MS, Chan J, Yuen KY, Lai KN (2003) A cluster of cases of severe acute respiratory syndrome in Hong Kong. New Engl J Med 348:1977–1985.CrossRefPubMedGoogle Scholar
  41. Tu CC, Crameri G, Kong XG, Chen JD, Sun YW, Yu M, Xiang H, Xia XZ, Liu SW, Ren T, Yu YD, Eaton BT, Xuan H, Wang L-F (2004) Antibodies to SARS coronavirus in civets. Emerg Infect Dis 10:2244–2248.PubMedGoogle Scholar
  42. Van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJM, Wolthers KC, Wertheim-van Dillen PME, Kaandorp J, Spaargaren J, Berkhout B (2004) Identification of a new human coronavirus. Nat Med 10:368–373.CrossRefPubMedGoogle Scholar
  43. Wang L-F, Eaton BT (2001) Emerging paramyxoviruses. Infect Dis Rev 3:52–69.Google Scholar
  44. Wang L-F, Shi Z, Zhang S, Field H, Daszak P, Eaton BT (2006) Review of bats and SARS. Emerg Infect Dis 12:1834–1840.PubMedGoogle Scholar
  45. Weingartl HM, Copps J, Drebot MA, Marszal P, Smith G, Gren J, Andonova M, Pasick J, Kitching P, Czub M (2004) Susceptibility of pigs and chickens to SARS coronavirus. Emerg Infect Dis 10:179–184.PubMedGoogle Scholar
  46. Wentworth DE, Gillim-Ross L, Espina N, Bernard KA (2004) Mice susceptible to SARS coronavirus. Emerg Infect Dis 10:1293–1296.PubMedGoogle Scholar
  47. World Health Organization (2004) Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. http://www.who.int/csr/sars/country/table2003_09_23/en/. Cited 26 February 2007.
  48. Woo PCY, Lau SKP, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BHL, Wong HL, Poon RWS, Cai JJ, Luk WK, Poon LLM, Wong SSY, Guan Y, Peiris JSM, Yuen KY (2005) Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol 79:884–895.CrossRefPubMedGoogle Scholar
  49. Wu DL, Tu CC, Xin C, Xuan H, Meng QW, Liu YG, Yu YD, Guan YT, Jiang Y, Yin XN, Crameri G, Wang MP, Li CW, Liu SW, Liao M, Feng L, Xiang H, Sun JF, Chen JD, Sun YW, Gu SL, Liu NH, Fu DX, Eaton BT, Wang L-F, Kong XG (2005) Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates. J Virol 79:2620–2625.CrossRefPubMedGoogle Scholar
  50. Xu RH, He JF, Evans MR, Peng GW, Field HE, Yu DW, Lee CK, Luo HM, Lin WS, Lin P, Li LH, Liang WJ, Lin JY, Schnur A (2004) Epidemiologic clues to SARS origin in China. Emerg Infect Dis 10:1030–1037.PubMedGoogle Scholar
  51. Yang ZY, Werner HC, Kong WP, Leung K, Traggiai E, Lanzavecchia A, Nabel GJ (2005) Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc Natl Acad Sci U S A 102:797–801.CrossRefPubMedGoogle Scholar
  52. Yu D, Li H, Xu R, He J, Lin J, Li L, Li W, Xu H, Huang S, Huang J (2003) Prevalence of IgG antibody to SARS-associated coronavirus in animal traders—Guangdong Province China, 2003. Morb Mort Wkly Rep 52:986–987.Google Scholar
  53. Zheng BJ, Guan Y, Wong KH, Zhou J, Wong KL, Young BWY, Lu LW, Lee SS (2004) SARS-related virus predating SARS outbreak Hong Kong. Emerg Infect Dis 10:176–178.PubMedGoogle Scholar
  54. Zhong NS, Zheng BJ, Li YM, Poon LLM, Xie ZH, Chan KH, Li PH, Tan SY, Chang Q, Xie JP, Liu XQ, Xu J, Li DX, Yuen KY, Peiris JSM, Guan Y (2003) Epidemiology and cause of acute respiratory syndrome (SARS) in Guangdong People’s Republic of China, in February 2003. Lancet 362:1353–1358.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • L. -F. Wang
    • 1
  • B. T. Eaton
    • 1
  1. 1.CSIRO Livestock IndustriesAustralian Animal Health LaboratoryGeelongAustralia

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