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Group I Ribozymes as a Paradigm for RNA Folding and Evolution

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Book cover Non-Protein Coding RNAs

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 13))

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Group I ribozymes are an ancient class of RNA catalysts that serve as a paradigm for the self-assembly of complex structures of non-coding RNA. The diversity of subtypes illustrates the modular character of RNA architecture and the potential for the evolution of new functions. The folding mechanisms of group I ribozymes illustrate the hierarchy of folding transitions and the importance of kinetic partitioning among competing folding pathways. Studies on group I splicing factors demonstrate how proteins facilitate the assembly of splicing complexes by stabilizing tertiary interactions between domains and by ATP-dependent cycles of RNA unfolding.

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Authors
  1. Dr. Sarah A. Woodson
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  2. Seema Chauhan
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Correspondence to Sarah A. Woodson .

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Editors and Affiliations

  1. Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI, 48109-1055, USA

    Nils G. Walter (Associate Professor of Chemistry) (Associate Professor of Chemistry)

  2. Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA

    Sarah A. Woodson (Professor of Biophysics) (Professor of Biophysics)

  3. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Box 215, Boulder, CO, 80309-0215, USA

    Robert T. Batey (Associate Professor of Chemistry and Biochemistry) (Associate Professor of Chemistry and Biochemistry)

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Woodson, S.A., Chauhan, S. (2009). Group I Ribozymes as a Paradigm for RNA Folding and Evolution. In: Walter, N.G., Woodson, S.A., Batey, R.T. (eds) Non-Protein Coding RNAs. Springer Series in Biophysics, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70840-7_7

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