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Signal Transduction and Morphogenesis in Candida albicans

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Biology of the Fungal Cell

Part of the book series: The Mycota ((MYCOTA,volume 8))

Abstract

Morphogenetic transitions between budding and filamentous growth forms are thought to contribute to the virulence of Candida albicans. We review the major advances in our understanding of the signal transduction pathways that regulate yeast-hypha morphogenesis in this major fungal pathogen of humans. A diverse range of morphogenetic stimuli are known to promote hyphal growth, including ambient temperatures over 36 C, ambient pH’s above 7.0, serum, glucose, hypoxia, CO2, embedding within a physical matrix and hormones. These regulate morphogenesis via multiple signal transduction pathways that include evolutionarily conserved MAP kinase, cAMP-protein kinase A and calcium signalling modules and an “alternative pathway” that activates hyphal development in response to hypoxia. The transcription factor Efg1 appears to act as a regulatory hub, controlling the activity of many of these pathways. Hyphal development is also subject to negative regulation by the global repressor, Tup1.

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Authors and Affiliations

  1. School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK

    A. J. P. Brown & N. A. R. Gow

  2. School of Medical Sciences, University of Aberdeen, Aberdeen

    S. Argimón

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  1. A. J. P. Brown
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  2. S. Argimón
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  3. N. A. R. Gow
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Editors and Affiliations

  1. DuPont Crop Genetics, Experimental Station E353 Powder Mill Road, Wilmington, DE, 19880-0353, USA

    Richard J. Howard

  2. School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK

    Neil A. R. Gow

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© 2007 Springer-Verlag Berlin Heidelberg

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Brown, A.J.P., Argimón, S., Gow, N.A.R. (2007). Signal Transduction and Morphogenesis in Candida albicans . In: Howard, R.J., Gow, N.A.R. (eds) Biology of the Fungal Cell. The Mycota, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70618-2_7

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