Skip to main content

Endoscopic Mucosal Resection for Staging and Therapy of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third

  • Chapter
  • First Online:
Adenocarcinoma of the Esophagogastric Junction

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 182))

Abstract

Minamally invasive endoscopic resection techniques allow definitive histological staging for dysplasia and early cancer and in many cases curative treatment. In Barrett’s esophagus with High Grade Dysplasia (HGD) or early mucosal cancer, endoscopic mucosal resection (EMR) should be considered both as diagnostic and therapeutic first line procedure, with the possibility to repeat the procedure in case of residual Barrett’s dysplasia or mucosal cancer. In early cancer of the the submucosa, surgical resection should be discussed. Endoscopic submucosal dissection (ESD) is a useful therapeutic option for HGD or early cancer in the squamous epithelium of the esophagus or in the stomach when en bloc resection is needed in large lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abe N et al (2002) Risk factors predictive of lymph node metastasis in depressed early gastric cancer. Am J Surg 183(2):168–172

    Article  PubMed  Google Scholar 

  • Chung IK et al (2009) Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study. Gastrointest Endosc 69(7):1228–1235

    Article  PubMed  Google Scholar 

  • Coda S et al (2009) Risk factors for cardiac and pyloric stenosis after endoscopic submucosal dissection, and efficacy of endoscopic balloon dilation treatment. Endoscopy 41(5):421–426

    Article  PubMed  CAS  Google Scholar 

  • Curvers WL et al (2008) Endoscopic tri-modal imaging for detection of early neoplasia in Barrett’s oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. Gut 57(2):167–172

    Article  PubMed  CAS  Google Scholar 

  • Fujishiro M et al (2006) Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol 4(6):688–694

    Article  PubMed  Google Scholar 

  • Ginsberg GG (2008) Endoscopic approaches to Barrett’s oesophagus with high-grade dysplasia/early mucosal cancer. Best Pract Res Clin Gastroenterol 22(4):751–772

    Article  PubMed  Google Scholar 

  • Giovannini M et al (2004) Circumferential endoscopic mucosal resection in Barrett’s esophagus with high-grade intraepithelial neoplasia or mucosal cancer. Preliminary results in 21 patients. Endoscopy 36(9):782–787

    Google Scholar 

  • Gondrie JJ et al (2008) Stepwise circumferential and focal ablation of Barrett’s esophagus with high-grade dysplasia: results of the first prospective series of 11 patients. Endoscopy 40(5):359–369

    Article  PubMed  CAS  Google Scholar 

  • Goto O et al (2009) Outcomes of endoscopic submucosal dissection for early gastric cancer with special reference to validation for curability ­criteria. Endoscopy 41(2):118–122

    Article  PubMed  CAS  Google Scholar 

  • Gotoda T (2008) Endoscopic resection for premalignant and malignant lesions of the gastrointestinal tract from the esophagus to the colon. Gastrointest Endosc Clin North Am 18(3):435–450

    Article  Google Scholar 

  • Green S et al (2009) Surgery versus radical endotherapies for early cancer and high grade dysplasia in Barrett’s oesophagus. Cochrane Database Syst Rev 2: CD007334

    Google Scholar 

  • Holt AP, Patel M, Ahmed MM (2004) Palliation of patients with malignant gastroduodenal obstruction with self-expanding metallic stents: the treatment of choice? Gastrointest Endosc 60(6):1010–1017

    Article  PubMed  Google Scholar 

  • Hull MJ et al (2006) Endoscopic mucosal resection: an improved diagnostic procedure for early gastroesophageal epithelial neoplasms. Am J Surg Pathol 30(1):114–118

    Article  PubMed  Google Scholar 

  • Inoue H, Endo M (1990) Endoscopic esophageal mucosal resection using a transparent tube. Surg Endosc 4(4):198–201

    Article  PubMed  CAS  Google Scholar 

  • Ishihara R et al (2008) Local recurrence of large squamous-cell carcinoma of the esophagus after endoscopic resection. Gastrointest Endosc 67(6):799–804

    Article  PubMed  Google Scholar 

  • Kato H et al (2001) Lifting of lesions during endoscopic mucosal resection (EMR) of early colorectal cancer: implications for the assessment of resectability. Endoscopy 33(7):568–573

    Article  PubMed  CAS  Google Scholar 

  • Larghi A, Waxman I (2007) State of the art on endoscopic mucosal resection and endoscopic submucosal dissection. Gastrointest Endosc Clin North Am 17(3):441–469

    Article  Google Scholar 

  • Larghi A et al (2007) Long-term follow-up of complete Barrett’s eradication endoscopic mucosal resection (CBE-EMR) for the treatment of high grade dysplasia and intramucosal carcinoma. Endoscopy 39(12):1086–1091

    Article  PubMed  CAS  Google Scholar 

  • May A et al (2002a) Local endoscopic therapy for intraepithelial high-grade neoplasia and early adenocarcinoma in Barrett’s oesophagus: acute-phase and intermediate results of a new treatment approach. Eur J Gastroenterol Hepatol 14(10):1085–1091

    Article  PubMed  Google Scholar 

  • May A et al (2002b) Intraepithelial high-grade neoplasia and early adenocarcinoma in short-­segment Barrett’s esophagus (SSBE): curative treatment using local endoscopic treatment techniques. Endoscopy 34(8):604–610

    Article  PubMed  CAS  Google Scholar 

  • Miyamoto S et al (2002) A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms. Gastrointest Endosc 55(4):576–581

    Article  PubMed  Google Scholar 

  • Odze RD, Lauwers GY (2008) Histopathology of Barrett’s esophagus after ablation and endoscopic mucosal resection therapy. Endoscopy 40(12): 1008–1015

    Article  PubMed  CAS  Google Scholar 

  • Ono H (2006) Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes. Eur J Gastroenterol Hepatol 18(8):863–866

    Article  PubMed  Google Scholar 

  • Pech O et al (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57(9):1200–1206

    Article  PubMed  CAS  Google Scholar 

  • Peters FP et al (2006) Stepwise radical endoscopic resection is effective for complete removal of Barrett’s esophagus with early neoplasia: a prospective study. Am J Gastroenterol 101(7):1449–1457

    Article  PubMed  Google Scholar 

  • Pohl J et al (2008) Endoscopic resection of early esophageal and gastric neoplasias. Dig Dis 26(4):285–290

    Article  PubMed  Google Scholar 

  • Pouw RE, Bergman JJ (2008) Endoscopic resection of early oesophageal and gastric neoplasia. Best Pract Res Clin Gastroenterol 22(5):929–943

    Article  PubMed  Google Scholar 

  • Rastogi A et al (2008) Incidence of esophageal adenocarcinoma in patients with Barrett’s esophagus and high-grade dysplasia: a meta-analysis. Gastrointest Endosc 67(3):394–398

    Article  PubMed  Google Scholar 

  • Rosch T et al (2004) Attempted endoscopic en bloc resection of mucosal and submucosal tumors using insulated-tip knives: a pilot series. Endo­scopy 36(9):788–801

    Article  PubMed  CAS  Google Scholar 

  • Saito Y et al (2008) Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection. Dig Dis Sci 53(2):330–333

    Article  PubMed  CAS  Google Scholar 

  • Seewald S et al (2003) Circumferential EMR and complete removal of Barrett’s epithelium: a new approach to management of Barrett’s esophagus containing high-grade intraepithelial neoplasia and intramucosal carcinoma. Gastrointest Endosc 57(7):854–859

    Article  PubMed  Google Scholar 

  • Shaheen NJ et al (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Engl J Med 360(22):2277–2288

    Article  PubMed  CAS  Google Scholar 

  • Siddiqui J, Gerke H (2008) Efficacy and safety of band ligator assisted mucosal resection to completely remove Barrett’s esophagus with high grade dysplasia or early cancer. Gastrointest Endosc 67(5): AB177–AB177

    Google Scholar 

  • Soehendra N et al (2006) Use of modified multiband ligator facilitates circumferential EMR in Barrett’s esophagus (with video). Gastrointest Endosc 63(6):847–852

    Article  PubMed  Google Scholar 

  • Uedo N et al (2006) Longterm outcomes after endoscopic mucosal resection for early gastric cancer. Gastric Cancer 9(2):88–92

    Article  PubMed  Google Scholar 

  • van der Burgh A et al (1996) Oesophageal cancer is an uncommon cause of death in patients with Barrett’s oesophagus. Gut 39(1):5–8

    Article  PubMed  Google Scholar 

  • von Rahden BHA, Feith M, Stein HJ (2006) [Limited Surgical Resection Versus Local Endoscopic Therapy of Early Cancers of the Esophagogastric Junction]. Zentralbl Chir 131(2):97–104

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Henriette Heinrich .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Heinrich, H., Bauerfeind, P. (2009). Endoscopic Mucosal Resection for Staging and Therapy of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third. In: Schneider, P. (eds) Adenocarcinoma of the Esophagogastric Junction. Recent Results in Cancer Research, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70579-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-70579-6_7

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-70578-9

  • Online ISBN: 978-3-540-70579-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics