Advertisement

Quantifying Effects of Class I Anti-arrhythmic Drugs in Human Virtual Cardiac Tissues

  • Alan P. Benson
  • Jennifer A. Lawrenson
  • Stephen H. Gilbert
  • Arun V. Holden
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5104)

Abstract

Ventricular tachycardia and fibrillation are dangerous cardiac arrhythmias. Anti-arrhythmic drugs such as lidocaine (a class I drug) reinstate normal sinus rhythm, but they have pro-arrhythmic side effects and their mechanisms of action are poorly understood. We used computational models of human ventricular tissues to elucidate and quantify these mechanisms.

Keywords

Cardiac tissue Computational modelling Class I antiarrhythmic drugs Re-entry. 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Chaudhry, G.M., Haffajee, C.I.: Anti-arrhythmic agents and pro-arrhythmia. Crit. Care Med. 28, N158–N164 (2000)CrossRefGoogle Scholar
  2. 2.
    Ten Tusscher, K.H.W.J., Panfilov, A.V.: Alternans and spiral breakup in a human ventricular tissue model. Am. J. Physiol. 291, H1088–H1100 (2006)Google Scholar
  3. 3.
    Starmer, C.F., Lastra, A.A., Nesterenko, V.V., Grant, A.O.: Pro-arrhythmic response to sodium channel blockade. Circulation 84, 1364–1377 (1991)Google Scholar
  4. 4.
    Furukawa, T., Koumi, S.-I., Sakakibara, Y., Singer, D.H., Jia, H., Arentzen, C.E., Backer, C.L., Wasserstrom, J.A.: An analysis of lidocaine block of sodium current in isolated human atrial and ventricular myocytes. J. Mol. Cell. Cardiol. 27, 831–846 (1995)CrossRefGoogle Scholar
  5. 5.
    Benson, A.P., Halley, G., Li, P., Tong, W.C., Holden, A.V.: Virtual cell and tissue dynamics of ectopic activation of the ventricles. Chaos 17, 015105 (2007)CrossRefMathSciNetGoogle Scholar
  6. 6.
    Weirich, J., Antoni, H.: Rate-dependence of anti-arrhythmic and pro-arrhythmic properties of class I and class III anti-arrhythmic drugs. Basic Res. Cardiol. 93, 125–132 (1998)CrossRefGoogle Scholar
  7. 7.
    Benson, A.P., Aslanidi, O.V., Zhang, H., Holden, A.V.: The canine virtual ventricles: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Prog. Biophys. Mol. Biol. 96, 187–208 (2008)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Alan P. Benson
    • 1
  • Jennifer A. Lawrenson
    • 2
  • Stephen H. Gilbert
    • 1
  • Arun V. Holden
    • 1
  1. 1.Institute of Membrane and Systems Biology & Multidisciplinary Cardiovascular Research CentreUniversity of LeedsLeedsUK
  2. 2.School of MedicineUniversity of LeedsLeedsUK

Personalised recommendations