Quantifying Effects of Class I Anti-arrhythmic Drugs in Human Virtual Cardiac Tissues
Ventricular tachycardia and fibrillation are dangerous cardiac arrhythmias. Anti-arrhythmic drugs such as lidocaine (a class I drug) reinstate normal sinus rhythm, but they have pro-arrhythmic side effects and their mechanisms of action are poorly understood. We used computational models of human ventricular tissues to elucidate and quantify these mechanisms.
KeywordsCardiac tissue Computational modelling Class I antiarrhythmic drugs Re-entry.
Unable to display preview. Download preview PDF.
- 2.Ten Tusscher, K.H.W.J., Panfilov, A.V.: Alternans and spiral breakup in a human ventricular tissue model. Am. J. Physiol. 291, H1088–H1100 (2006)Google Scholar
- 3.Starmer, C.F., Lastra, A.A., Nesterenko, V.V., Grant, A.O.: Pro-arrhythmic response to sodium channel blockade. Circulation 84, 1364–1377 (1991)Google Scholar