Meconium ileus is the earliest clinical manifestation of cystic fibrosis (CF) and occurs in 8–10% of patients with CF at birth. The clinical features are mainly due to the presence of abnormal, inspissated and viscid mucus of intestinal origin. In neonates affected by this condition, the impacted meconium produces an intralu-minal obstruction occurring in the midileum, leading to a progressive distension. About 40% of patients with meconimu ileus are complicated by intestinal volvulus, atresia, gangrene and necrosis, perforation, peritonitis with abdominal calcifi cations and, fi nally, meconial pseudocyst.
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Blackman SM, Deering-Brose R, McWilliams R et al (2006) Relative contribution of genetic and nongenetic modifi ers to intestinal obstruction in cystic fi brosis. Gastroenterology 131(4):1030–1039
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Munck A, Gerardin M, Alberti C, et al (2006) Clinical outcome of cystic fi brosis presenting with or without meco-nium ileus: A matched cohort study. J Pediatr Surg 41(9): 1556–1560
Rivosecchi M (2006) Meconium ileus. In P Puri, ME Höllwarth (eds) Pediatric Surgery. Springer, Surgery Atlas Series, Springer-Verlag Berlin Heidelberg, New York, pp 229–238
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Rivosecchi, M. (2009). Meconium Ileus. In: Puri, P., Höllwarth, M. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69560-8_42
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DOI: https://doi.org/10.1007/978-3-540-69560-8_42
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