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Signalling from Internalized Growth Factor Receptors pp 119–148Cite as

Clathrin-Independent Endocytosis and Signalling of Interleukin 2 Receptors

IL-2R Endocytosis and Signalling

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 286))

Abstract

Abstract Interleukin 2 receptors (IL-2R) belong to the cytokine receptor family and share subunits with other members of the family. They are essential in T cell activation and in maintaining homeostatic immune responses. These receptors do not have an intrinsic kinase activity and use multiple signalling pathways. Their endocytic pathway is different from that of classic growth factor receptors in that it does not follow the classic clathrin-coated pit and vesicle route. After uptake, one of the IL-2R chains, α, recycles to the plasma membrane, whereas the two other chains, β and γ, are targeted to late endosomes/lysosomes and degraded. This involves ubiquitination of the receptor as a sorting signal. Links between the signalling events, internalisation and intracellular sorting of these receptors are reviewed.

contributed equally to this chapter

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Authors and Affiliations

  1. Unité de Biologie des Interactions Cellulaires - URA CNRS 2582, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris Cedex 15, France

    F. Gesbert, N. Sauvonnet & A. Dautry-Varsat

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  1. F. Gesbert
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  2. N. Sauvonnet
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  3. A. Dautry-Varsat
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Editors and Affiliations

  1. Institute of Pathology, Rikshospitalet University Hospital, 0027, Oslo, Norway

    Inger Helene Madshus M.D., Ph.D.

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© 2004 Springer-Verlag Berlin Heidelberg

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Gesbert, F., Sauvonnet, N., Dautry-Varsat, A. (2004). Clathrin-Independent Endocytosis and Signalling of Interleukin 2 Receptors. In: Madshus, I.H. (eds) Signalling from Internalized Growth Factor Receptors. Current Topics in Microbiology and Immunology, vol 286. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69494-6_5

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  • DOI: https://doi.org/10.1007/978-3-540-69494-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05912-4

  • Online ISBN: 978-3-540-69494-6

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