The Role of Ocular Blood Flow Abnormalities in the Pathogenesis of Glaucoma

  • Balwantray C. ChauhanEmail author

Core Messages

  • Glaucoma is a group of optic neuropathies and a leading cause of blindness worldwide. Open-angle glaucoma is the most common form of the neuropathy clinically characterised by pathological optic disc cupping and visual field change.

  • Intraocular pressure (IOP) is uniformly recognised as the major known causative risk factor for the development and progression of the neuropathy. Treatment to lower IOP reduces the incidence and progression of glaucoma. Nonetheless, a significant proportion of patients continue to progress in spite of successful IOP reduction, suggesting that in at least some patients, other factors are responsible for the disease. One of the earliest identified additional risk factors is optic nerve head ischaemia.

  • Epidemiological studies provide compelling evidence that ocular (particularly diastolic) perfusion pressure is related to glaucoma. A putative result of faulty autoregulation to low perfusion pressure in order to maintain adequate blood flow is an...


Optic Nerve Perfusion Pressure Optic Nerve Head Glaucoma Patient Central Retinal Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Supported by Grant MOP57851 from the Canadian Institutes of Health Research.


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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual SciencesDalhousie UniversityHalifaxCanada

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