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Ocular Blood Flow in Diabetes: Contribution to the Microvascular Lesions of Diabetic Retinopathy

  • Tim M. CurtisEmail author
  • Tom A. Gardiner
Chapter

Core Messages

  • Diabetic retinopathy is a leading cause of vision loss in the working population of developed countries.

  • Changes in retinal haemodynamics have been proposed to play a key role in the initiation and progression of diabetic retinopathy.

  • Substantial evidence suggests that there is an early reduction in retinal perfusion prior to the onset of diabetic retinopathy followed by a gradual increase in blood flow as the disease progresses.

  • Two major mechanisms have been ­proposed to explain how hyperglycaemia decreases retinal blood flow in early diabetes, namely, protein kinase C (PKC) activation and ion channel dysfunction in the contractile mural cells of retinal microvessels.

  • The functional reduction in retinal blood flow observed during early diabetic retinopathy may be additive or synergistic to pro-inflammatory changes, leukostasis and vaso-occlusion and thus may be intimately linked to the progressive ischaemic hypoxia and increased blood flow associated with later stages...

Keywords

Vascular Endothelial Growth Factor Diabetic Retinopathy Proliferative Diabetic Retinopathy Proliferative Retinopathy Ocular Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Centre for Vision and Vascular Sciences School of Medicine, Dentistry and Biomedical SciencesThe Queen’s University of Belfast, Institute of Clinical Science - Block A, Royal Victoria HospitalBelfastUK
  2. 2.Centre for Biomedical Sciences Education, School of Medicine, Dentistry and Biomedical SciencesThe Queen’s University of BelfastBelfastUK

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