Abstract
Appreciation for the clinical meaning of even small changes in kidney function has radically changed the way patients are being cared for. Analogous to chronic kidney disease (CKD) in the outpatient arena, acute kidney injury (AKI) is associated with both short- and long-term adverse outcomes in hospitalized patients. The RIFLE classification has been validated in multiple studies and may be utilized as a prognostic tool. Evaluation of the epidemiology of AKI has been hampered by the lack of a standard definition and classification system. New studies involving multiple, different populations are clarifying the incidence and prevalence of this syndrome. However, the condition appears to be common (approximately 30–50% of critically ill patients) and is associated with a large increase in the risk of death (3–5-fold increase). As new treatments for AKI emerge, RIFLE classifications will undoubtedly be used to reference recommendations for prevention and treatment.
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Karajala, V., Kellum, J.A. (2010). Definition and Classification of Acute Kidney Injury. In: Jörres, A., Ronco, C., Kellum, J. (eds) Management of Acute Kidney Problems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69441-0_1
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DOI: https://doi.org/10.1007/978-3-540-69441-0_1
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