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Biomedical Nanotechnology Using Virus-Based Nanoparticles

  • Chapter
Viruses and Nanotechnology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 327))

A great challenge in biomedicine is the ability to target therapeutics to specific locations in the body in order to increase therapeutic benefit and minimize adverse effects. Virus-based nanotechnology takes advantage of the natural circulatory and targeting properties of viruses, in order to design therapeutics and vaccines that specifically target tissues of interest in vivo. Cowpea mosaic virus (CPMV) and flock house virus (FHV) nanoparticle-based strategies hold great promise for the design of targeted therapeutics, as well as for structure-based vaccine approaches.

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Abbreviations

APC:

Antigen-presenting cell

CCMV:

Cowpea chlorotic mottle virus

CEA:

Carcinoembryonic antigen

CPMV:

Cowpea mosaic virus

CTL:

Cytotoxic T-lymphocyte

cDNA:

Complementary deoxyribonucleic acid

DC:

Dendritic cell,DMSO Dimethyl sulfoxide

ELISA:

Enzyme-linked immunosorbent assay

FA:

Folic acid

FHV:

Flock house virus

MHC:

Major histocompatibility complex

MRI:

Magnetic resonance imaging

NHS:

N-hydroxysuccinimide

NPY:

Neuropeptide Y

QD:

Quantum dots

RNA:

Ribonucleic acid

SWCNT:

Single-walled carbon nanotubes

USPIO:

Ultra-small paramagnetic iron oxide

UV:

Ultraviolet

VNP:

Viral nanoparticles

VLP:

Virus-like particle

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Authors and Affiliations

  1. Kirin Pharma USA, Inc., 9420 Athena Circle, La Jolla, CA, 92037

    G. Destito

  2. Department of Molecular Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, CB248 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    A. Schneemann & M. Manchester

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  1. G. Destito
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  2. A. Schneemann
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  1. Department of Cell Biology Center for Integrative Molecular Biosciences, Scripps Research Institute, 10550 N. Torrey Pines Road, CB262, La Jolla, CA, 92037, USA

    Marianne Manchester  & Nicole F. Steinmetz  & 

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Destito, G., Schneemann, A., Manchester, M. (2009). Biomedical Nanotechnology Using Virus-Based Nanoparticles. In: Manchester, M., Steinmetz, N.F. (eds) Viruses and Nanotechnology. Current Topics in Microbiology and Immunology, vol 327. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69379-6_5

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