Abstract
A crucial factor of comedogenesis is hyperkeratinization in the infundibulum and sebaceous duct. The initial event (early phase) in acne vulgaris is hyperkeratinization in the infundibulum. Although there have been many intensive studies of the pathogenesis of hyperkeratinization in infundibulum and sebaceous duct, the process of hyperkeratinization remains unclear. The mechanism of this hyperkeratinization is described in its clinical, histological, and etiological aspects below.
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References
Cunliffe WJ, Holland DB, Clark SM, et al. Comedogenesis: some aetiological, clinical and therapeutic strategies. Dermatology. 2003;206:11–6.
Gollnick H. Current concepts of the pathogenesis of acne: implications for drug treatment. Drugs. 2003;63:1579–96.
Plewig G, Kligman AM. Acne & Rosacea. 3rd ed. Berlin: Springer; 2002.
Kurokawa I, Mayer-da-Silva A, Gollnick H, et al. Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilosebaceous unit of normal, seborrhoeic and acne skin. J Invest Dermatol. 1988;91:566–71.
Knutson DD. Ultrastructural observations in acne vulgaris: the normal sebaceous follicle and acne lesions. J Invest Dermatol. 1974;62:288–307.
Toyoda M, Morohashi M. Pathogenesis of acne. Med Electron Microsc. 2001;34:29–40.
Dale BA, Ling SY. Immunologic cross-reaction of stratum corneum basic protein and a keratohyalin granule protein. J Invest Dermatol. 1979;72:257–61.
Kurokawa I, Nakai Y, Nishimura K, et al. Cytokeratin and filaggrin expression in nevus comedonicus. J Cutan Pathol. 2007;34:338–41.
Kurokawa I, Umeda K, Nishimura K, et al. Filaggrin expression and the pathogenesis of epidermal cysts. Br J Dermatol. 2007;157:415–6.
Knags HE, Holland DB, Morris C, et al. Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. J Invest Dermatol. 1994;102:89–92.
Hughes BR, Morris C, Cunliffe WJ, et al. Keratin expression in pilosebaceous epithelia in truncal skin of acne patients. Br J Dermatol. 1996;134:247–56.
Knags HE, Hughes BR, Morris C, et al. Immunohistochemical study of desmosomes in acne vulgaris. Br J Dermatol. 1994;130:731–7.
Knags HE, Layton AM, Morris C, et al. Investigation of the expression of the extracellular matrix glycoproteins tenascin and fibronectin during acne vulgaris. Br J Dermatol. 1994;130:576–82.
Forssman T. Antibiotic resistance in acne patients under antibiotic treatment in comparison to an untreated control group with retrospective assessment of therapy. Curr Probl Dermatol. 1995;22:91–7.
Ingham E, Walters CE, Eady EA, et al. Inflammation in acne vulgaris: failure of skin micro-organisms to modulate keratinocyte interleukin 1 alpha production in vitro. Dermatology. 1998;196:86–8.
Guy R, Green MR, Kealey T. Modeling acne in vitro. J Invest Dermatol. 1996;106:176–82.
Gollnick H, Cunliffe W, Berson D, et al. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2003;49:S1–37.
Thiboutot D, Knaggs H, Gilliland K, et al. Activity of 5-alpha-reductase and 17-beta-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris. Dermatology. 1998;196:38–42.
Thiboutot DM, Knaggs H, Gilliland K, et al. Activity of type 1 5 alpha-reductase is greater in the follicular infrainfundibulum compared with the epidermis. Br J Dermatol. 1997;136:166–71.
Downing DT, Stewart ME, Wertz PW, et al. Essential fatty acids and acne. J Am Acad Dermatol. 1986;14:221–5.
Letawe C, Boone M, Pierard GE. Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones. Clin Exp Dermatol. 1998;23:56–8.
Saint-Leger D, Bague A, Lefebvre E, et al. A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. Br J Dermatol. 1986;114:543–52.
Shalita AR. Genesis of free fatty acids. J Invest Dermatol. 1974;62:332–5.
Jarrousse V, Castex-Rizzi N, Khammari A, et al. Modulation of integrands and filaggrin expression by Propionibacterium acnes extracts on keratinocytes. Arch Dermatol Res. 2007;299:441–7.
Watt FM. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 2002;21:3919–26.
Plewig G, Fulton JE, Kligman AM. Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch. 1971;242:12–29.
Zouboulis CC, Eady A, Philpott M, et al. What is the pathogenesis of acne? Exp Dermatol. 2005;14:143–52.
Downie MM, Sanders DA, Kealey T. Modelling the remission of individual acne lesions in vitro. Br J Dermatol. 2002;147:869–78.
Motoyoshi K. Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxides. Br J Dermatol. 1983;109:191–8.
Ingham E, Eady EA, Goodwin CE, et al. Pro-inflammatory levels of interleukin-1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol. 1992;98:895–901.
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Kurokawa, I. (2014). The Role of Hyperkeratinization. In: Zouboulis, C., Katsambas, A., Kligman, A. (eds) Pathogenesis and Treatment of Acne and Rosacea. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69375-8_9
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DOI: https://doi.org/10.1007/978-3-540-69375-8_9
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