Skip to main content
SpringerLink
Log in

Urinary Hormone Analysis in Acne

  • Chapter
Pathogenesis and Treatment of Acne and Rosacea

  • 3098 Accesses

Abstract

The analysis of urinary steroid hormone metabolites allows to detect multiple endocrinopathies involved in the evolution of acne. The word “profile,” introduced in the mid-1960s represents a multicomponent chromatographic analysis permitting to identify individual traits [1]. The ultimate goal of a single profile determining all components of interest with sufficient quantitative and qualitative discrimination has not yet been achieved. Pattern analysis is clearly an advantage of steroid hormone metabolite profiling in order to detect inborn or acquired errors of metabolism [2, 3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 239.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Shackleton CH. Profiling steroid hormones and urinary steroids. J Chromatogr. 1986;379:91–156.

    Article  CAS  PubMed  Google Scholar 

  2. Gaskell SJ. Analysis of steroids by mass spectrometry. Methods Biochem Anal. 1983;29:385–434.

    Article  CAS  PubMed  Google Scholar 

  3. Sjovall J, Axelson M. Newer approaches to the isolation, identification, and quantitation of steroids in biological materials. Vitam Horm. 1982;39:31–144.

    Article  CAS  PubMed  Google Scholar 

  4. Pang SY, Lerner AJ, Stoner E, Levine LS, Oberfield SE, Engel I, New MI. Late-onset adrenal steroid 3 beta-hydroxysteroid dehydrogenase deficiency. I. A cause of hirsutism in pubertal and postpubertal women. J Clin Endocrinol Metab. 1985;60(3):428–39.

    Article  CAS  PubMed  Google Scholar 

  5. Crapo L. Cushing’s syndrome: a review of diagnostic tests. Metabolism. 1979;28(9):955–77.

    Article  CAS  PubMed  Google Scholar 

  6. Mengden T, Hubmann P, Muller J, Greminger P, Vetter W. Urinary free cortisol versus 17-hydroxycorticosteroids: a comparative study of their diagnostic value in Cushing’s syndrome. Clin Investig. 1992;70(7):545–8.

    Article  CAS  PubMed  Google Scholar 

  7. Rodin A, Thakkar H, Taylor N, Clayton R. Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase. N Engl J Med. 1994;330(7):460–5.

    Article  CAS  PubMed  Google Scholar 

  8. Stewart PM, Shackleton CH, Beastall GH, Edwards CR. 5 alpha-reductase activity in polycystic ovary syndrome. Lancet. 1990;335(8687):431–3.

    Article  CAS  PubMed  Google Scholar 

  9. Tsilchorozidou T, Honour JW, Conway GS. Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates. J Clin Endocrinol Metab. 2003;88(12):5907–13.

    Article  CAS  PubMed  Google Scholar 

  10. Abdelhamid S, Blomer R, Hommel G, Haack D, Lewicka S, Fiegel P, Krumme B. Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study. Am J Hypertens. 2003;16(7):522–30.

    Article  CAS  PubMed  Google Scholar 

  11. Shojaati K, Causevic M, Kadereit B, Dick B, Imobersteg J, Schneider H, Beinder E, Kashiwagi M, Frey BM, Frey FJ, Mohaupt MG. Evidence for compromised aldosterone synthase enzyme activity in preeclampsia. Kidney Int. 2004;66:2322–8.

    Article  CAS  PubMed  Google Scholar 

  12. Mohaupt MG, von Vigier RO. Urinary hormone analysis. Ther Umsch. 2006;63(9):559–64.

    Article  CAS  PubMed  Google Scholar 

  13. Pang S, Levine LS, Stoner E, Opitz JM, Pollack MS, Dupont B, New MI. Nonsalt-losing congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency with normal glomerulosa function. J Clin Endocrinol Metab. 1983;56(4):808–18.

    Article  CAS  PubMed  Google Scholar 

  14. Quinkler M, Zehnder D, Lepenies J, Petrelli MD, Moore JS, Hughes SV, Cockwell P, Hewison M, Stewart PM. Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function. Eur J Endocrinol. 2005;153(2):291–9.

    Article  CAS  PubMed  Google Scholar 

  15. Vierhapper H, Nowotny P, Waldhausl W, Frisch H. Capillary gas chromatography as a tool for characterization of urinary steroid excretion in patients with congenital adrenal hyperplasia. J Steroid Biochem. 1985;22(3):363–9.

    Article  CAS  PubMed  Google Scholar 

  16. Dean HJ, Shackleton CH, Winter JS. Diagnosis and natural history of 17-hydroxylase deficiency in a newborn male. J Clin Endocrinol Metab. 1984;59(3):513–20.

    Article  CAS  PubMed  Google Scholar 

  17. Honour JW, Anderson JM, Shackleton CH. Difficulties in the diagnosis of congenital adrenal hyperplasia in early infancy: the 11 beta-hydroxylase defect. Acta Endocrinol (Copenh). 1983;103(1):101–9.

    CAS  Google Scholar 

  18. Levine LS, Rauh W, Gottesdiener K, Chow D, Gunczler P, Rapaport R, Pang S, Schneider B, New MI. New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1980;50(2):258–63.

    Article  CAS  PubMed  Google Scholar 

  19. Imperato-McGinley J, Peterson RE, Gautier T, Arthur A, Shackleton C. Decreased urinary C19 and C21 steroid 5 alpha-metabolites in parents of male pseudohermaphrodites with 5 alpha-reductase deficiency: detection of carriers. J Clin Endocrinol Metab. 1985;60(3):553–8.

    Article  CAS  PubMed  Google Scholar 

  20. Phillipou G, Higgins BA. A new defect in the peripheral conversion of cortisone to cortisol. J Steroid Biochem. 1985;22(3):435–6.

    Article  CAS  PubMed  Google Scholar 

  21. Jamieson A, Wallace AM, Andrew R, Nunez BS, Walker BR, Fraser R, White PC, Connell JM. Apparent cortisone reductase deficiency: a functional defect in 11beta-hydroxysteroid dehydrogenase type 1. J Clin Endocrinol Metab. 1999;84(10):3570–4.

    CAS  PubMed  Google Scholar 

  22. Pochi PE, Strauss JS. Sebum production, casual sebum levels, titratable acidity of sebum, and urinary fractional 17-ketosteroid excretion in males with acne. J Invest Dermatol. 1964;43:383–8.

    Article  CAS  PubMed  Google Scholar 

  23. Pochi PE, Strauss JS, Downing DT. Skin surface lipid composition, acne, pubertal development, and urinary excretion of testosterone and 17-ketosteroids in children. J Invest Dermatol. 1977;69(5):485–9.

    Article  CAS  PubMed  Google Scholar 

  24. Jefferies WM, Michelakis AM. Individual patterns of urinary 17-ketosteroid fractions. Metabolism. 1963;12:1017–31.

    CAS  PubMed  Google Scholar 

  25. Ruedi B, Margalith D, Magrini G, Burckhardt P. Diagnostic strategy in hyperandrogenic syndrome. Horm Res. 1983;18(1–3):117–24.

    CAS  PubMed  Google Scholar 

  26. Sauter LS. Urinary output of total and individual fractions of 17-ketosteroids in patients with acne. Dermatologica. 1965;131(4):343–54.

    Article  CAS  PubMed  Google Scholar 

  27. Rademaker M, Wallace M, Cunliffe W, Simpson NB. Isotretinoin treatment alters steroid metabolism in women with acne. Br J Dermatol. 1991;124(4):361–4.

    Article  CAS  PubMed  Google Scholar 

  28. Boudou P, Chivot M, Vexiau P, Soliman H, Villette JM, Julien R, Belanger A, Fiet J. Evidence for decreased androgen 5 alpha-reduction in skin and liver of men with severe acne after 13-cis-retinoic acid treatment. J Clin Endocrinol Metab. 1994;78(5):1064–9.

    CAS  PubMed  Google Scholar 

  29. Mauvais-Jarvis P, Charransol G, Bobas-Masson F. Simultaneous determination of urinary androstanediol and testosterone as an evaluation of human androgenicity. J Clin Endocrinol Metab. 1973;36(3):452–9.

    Article  CAS  PubMed  Google Scholar 

  30. Cathelineau G, Brerault JL, Fiet J, Julien R, Dreux C, Canivet J. Adrenocortical 11 beta-hydroxylation defect in adult women with postmenarchial onset of symptoms. J Clin Endocrinol Metab. 1980;51(2):287–91.

    Article  CAS  PubMed  Google Scholar 

  31. Emans SJ, Grace E, Goldstein DP. Oligomenorrhea in adolescent girls. J Pediatr. 1980;97(5):815–9.

    Article  CAS  PubMed  Google Scholar 

  32. Hurwitz A, Brautbar C, Milwidsky A, Vecsei P, Milewicz A, Navot D, Rosler A. Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1985;60(4):631–8.

    Article  CAS  PubMed  Google Scholar 

  33. Wolthers BG, Volmer M, van Seters AP. Detection of 3 beta-hydroxysteroid-dehydrogenase deficiency by urinary steroid profiling: solvolysis of urinary samples should be a necessary prerequisite. Clin Chim Acta. 1985;145(3):319–23.

    Article  CAS  PubMed  Google Scholar 

  34. Stratakis CA, Mastorakos G, Mitsiades NS, Mitsiades CS, Chrousos GP. Skin manifestations of Cushing disease in children and adolescents before and after the resolution of hypercortisolemia. Pediatr Dermatol. 1998;15(4):253–8.

    Article  CAS  PubMed  Google Scholar 

  35. Wudy SA, Homoki J, Wachter UA, Teller WM. Diagnosis of the adrenogenital syndrome caused by 11beta-hydroxylase deficiency using gas chromatographic-mass spectrometric analysis of the urinary steroid profile. Dtsch Med Wochenschr. 1997;122(1–2):3–10. discussion 11.

    Article  CAS  PubMed  Google Scholar 

  36. Phillips IJ, Conway EM, Hodkinson RA, Honour JW. External quality assessment of urinary steroid profile analysis. Ann Clin Biochem. 2004;41(Pt 6):474–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hypertension, Department of Nephrology and Hypertension, University of Bern, 3010, Berne, Switzerland

    Markus G. Mohaupt

  2. Department of Nephrology and Hypertension, University of Bern, Berne, Switzerland

    Bernhard Dick

Authors
  1. Markus G. Mohaupt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernhard Dick
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Markus G. Mohaupt .

Editor information

Editors and Affiliations

  1. Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany

    Christos C. Zouboulis

  2. Department of Dermatology, Andreas Syngros Hospital, University of Athens, Athens, Greece

    Andreas D. Katsambas

  3. Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Albert M. Kligman

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mohaupt, M.G., Dick, B. (2014). Urinary Hormone Analysis in Acne. In: Zouboulis, C., Katsambas, A., Kligman, A. (eds) Pathogenesis and Treatment of Acne and Rosacea. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69375-8_49

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-69375-8_49

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69374-1

  • Online ISBN: 978-3-540-69375-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation