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Vitamins and the Skin

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Pathogenesis and Treatment of Acne and Rosacea

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Abstract

Vitamin A (retinol) and its two main metabolites, retinaldehyde and retinoic acid, are critical for the development, maintenance, and differentiation of skin and other epithelial tissues. The normal plasma concentration of vitamin A is 0.35–0.75 μg/ml. Retinoids, vitamin A derivatives, are natural or synthetic molecules which have immunomodulatory and anti-inflammatory effects, influence the epidermal cell growth and differentiation, and have effects on sebaceous gland activity and epidermal lipids. A range of vitamin A derivatives have been approved for the topical or systemic treatment of mild to severe, recalcitrant acne, photoaging, psoriasis, and hand eczema [1, 2].

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Author information

Authors and Affiliations

  1. Skin Biology TRC, Johnson and Johnson Consumer Companies Worldwide, Skillman, NJ, USA

    Apostolos Pappas

  2. Department of Dermatology, Andeas Syngros Hospital, National and Capodistrian University of Athens, Athens, Greece

    Clio Dessinioti

  3. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany

    Aikaterini I. Liakou

Authors
  1. Apostolos Pappas
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  2. Clio Dessinioti
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  3. Aikaterini I. Liakou
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Correspondence to Apostolos Pappas .

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Editors and Affiliations

  1. Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany

    Christos C. Zouboulis

  2. Department of Dermatology, Andreas Syngros Hospital, University of Athens, Athens, Greece

    Andreas D. Katsambas

  3. Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Albert M. Kligman

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Pappas, A., Dessinioti, C., Liakou, A.I. (2014). Vitamins and the Skin. In: Zouboulis, C., Katsambas, A., Kligman, A. (eds) Pathogenesis and Treatment of Acne and Rosacea. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69375-8_48

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  • DOI: https://doi.org/10.1007/978-3-540-69375-8_48

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69374-1

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