Abstract
Acne constitutes a multifactorial skin disorder which has a very adverse psychological impact in all individuals but more so in adolescents [1, 2]. From many natural paradigms and from systematic studies, the role of hormones in the appearance of acne has been substantiated [1–4]. Specifically, androgens affect the pilosebaseous unit by inducing sebum production [5].
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References
Ballanger F, Baudry P, N’Guy JM, et al. Heredity: a prognostic factor for acne. Dermatology. 2006;212:145–9.
Cunliffe WJ, Baron SE, Coulson IH. A clinical and therapeutic study of 29 patients with infantile acne. Br J Dermatol. 2001;145:463–6.
Cordera F, Grant C, van Heerden J, et al. Androgen – secreting adrenal tumours. Surgery. 2003;134:874–80.
Dreno B, Poli F. Epidemiology of acne. Dermatology. 2003;206:7–10.
Jansen T, Burgdorf WHC, Plewing G. Pathogenesis and treatment of acne in childhood. Pediatr Dermatol. 1997;14:14–274.
De Raeve L, De Schepper J, Smitz J. Prepubertal acne: a cutaneous marker of androgen excess? J Am Acad Dermatol. 1995;32:181–4.
New MI. An repdate of congenital adrenal hyperplasia. Ann N Y Acad Sci. 2004;1038:14–43.
Dacou-Voutetakis C, Dracopoulou M. High incidence of molecular defects of the CYP21 gene in patients with premature adrenarche. J Clin Endocrinol Metab. 1999;84:1570–4.
Dacou-Voutetakis C, Dracopoulou M. Non-classical congenital adrenal hyperplasia. Pediatr Endocrinol Rev. 2006;3:195–7.
Dracopoulou-Vabouli M, Maniati-Christidi M, Dacou-Voutetakis C. The spectrum of Molecular defects of the CYP21 gene in the Hellenic population: variable concordance between genotype and phenotype in the different forms of congenital adrenal hyperpasia. J Clin Endocrinol Metab. 2001;86:2845–8.
Harde V, Műller M, Sippel WG, et al. Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. JDDG. 2006;4:654–7.
Dacou-Voutetakis C, Livadas S, Voutetakis A, et al. Adrenarche, premature. Encyclopedia of endocrine diseases. Elsevier Inc.; 2004. Pp 99–105.
Ibanez I, Bonnin MR, Zampoli M, et al. Usefulness of an ACTH test in the diagnosis of nonclassical 21-hydroxylase deficiency among children presenting with premature pubarche. Horm Res. 1995;44:51–6.
Witchel SF, Lee PA. Identification of heterozygotic carriers of 21-hydroxylase deficiency: sensitivity of ACTH stimulation tests. Am J Med Genet. 1998;76:337–42.
Ostleve LS, Rumsby G, Holownia P, et al. Carrier status for steroid 21-hydroxylase deficiency is only one factor in the variable phenotype of acne. Clin Endocrinol (Oxf). 1998;48:209–15.
Ibanez L, Dimartino-Nardi J, Potau N, et al. Premature adrenarche – normal variant or fore runner of adult disease? Endocr Rev. 2000;6:671–96.
Thalmann S, Meier CA. Acne and “mild” adrenal hyperplasia. Dermatology. 2006;213:277–8.
Degitz K, Placzek M, Arnold B, et al. Congenital adrenal hyperplasia and acne in male patients. Br J Dermatol. 2003;148:1263–6.
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Dacou-Voutetakis, C. (2014). Acne and Congenital Adrenal Hyperplasia. In: Zouboulis, C., Katsambas, A., Kligman, A. (eds) Pathogenesis and Treatment of Acne and Rosacea. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69375-8_46
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DOI: https://doi.org/10.1007/978-3-540-69375-8_46
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