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Abstract

Acne fulminans (also referred as acute febrile ulcerating acne conglobata with polyarthralgia and leukemoid reaction, or acne maligna) is a serious disease of sudden onset, associated with systemic symptoms and abnormal laboratory findings [1]. The term acne fulminans was coined by Plewig and Kligman in 1975 in order to describe acute febrile ulcerative acne conglobata with polyarthralgia and is considered a very uncommon complication of acne [2, 3].

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References

  1. Jansen T, Plewig G. Acne fulminans. Int J Dermatol. 1998;37:254–7.

    Article  CAS  PubMed  Google Scholar 

  2. Plewig G, Kligman AM. Acne fulminans. Acne. Berlin: Springer 1975:196

    Google Scholar 

  3. Seukeran DC, Cunliffe WJ. The treatment of acne fulminans: a review of 25 cases. Br J Dermatol. 1999;141:307–9.

    Article  CAS  PubMed  Google Scholar 

  4. Knitzer R, Needleman B. Musculoskeletal syndromes associated with acne. Semin Arthritis Rheum. 1991;20:247–55.

    Article  CAS  PubMed  Google Scholar 

  5. Karvonen SL, Rasamen L, Cunliffe WJ, et al. Delayed hypersensitivity to Propionibacterium acnes in patients with severe nodular acne and acne fulminans. Dermatology. 1994;189:344–9.

    Article  CAS  PubMed  Google Scholar 

  6. Gowland G, Ward RM, Holland KT, et al. Cellular immunity to Propionibacterium acnes in the normal population and patients with acne vulgaris. Br J Dermatol. 1978;99:43–7.

    Article  CAS  PubMed  Google Scholar 

  7. Kellett JK, Beck MH, Chalmers RJG. Erythema nodosum and circulating immune complexes in acne fulminans after treatment with isotretinoin (Letter). Br Med J. 1985;290:820.

    Article  CAS  Google Scholar 

  8. Williamson DM, Cunliffe WJ, Catecliff M, et al. Acute ulcerative acne conglobata (acne fulminans) with erythema nodosum. Clin Exp Dermatol. 1977;2:351–2.

    Article  CAS  PubMed  Google Scholar 

  9. Jansen T, Romiti R, Plewig G. Acute severe acne in a female patient (acne fulminans?). Br J Dermatol. 1999;141:945–7.

    Article  CAS  PubMed  Google Scholar 

  10. Blanc D, Zultak M, Wemdling D, et al. Eruptive pyogenic granulomas and acne fulminans in two siblings treated with isotretinoin. Dermatologica. 1998;18:543–52.

    Google Scholar 

  11. Mehrany K, Kist JM, Weenig RH, et al. Acne fulminans. Int J Dermatol. 2005;44:132–3.

    Article  PubMed  Google Scholar 

  12. Siong Wong SAI, Pritchard MH, Holt PJA. Familial acne fulminans. Clin Exp Dermatol. 1992;17:351–3.

    Article  Google Scholar 

  13. Messer G, Spengler U, Jung MC, et al. Polymorphic structure of the TNF locus: a Ncol polymorphism in the first intron of the human TNF-β gene correlates with a variant amino acid in position 26 and reduced level of TNF-β production. J Exp Med. 1991;173:209–19.

    Article  CAS  PubMed  Google Scholar 

  14. Wilson AG, de Vries N, Pociot F, et al. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with the HLA A1, B8 and DR3 alleles. J Exp Med. 1993;177:577–80.

    Article  Google Scholar 

  15. Iqbal M, Kolodney MS. Acne fulminans with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome treated with infliximab. J Am Acad Dermatol. 2005;52:S118–20.

    Article  PubMed  Google Scholar 

  16. Statham BN, Holt PJA, Pritchard MH. Acne fulminans-report of a case with polyarthritis. Clin Exp Dermatol. 1983;8:401–4.

    Article  CAS  PubMed  Google Scholar 

  17. Thomson KF, Cunliffe WJ. Acne fulminans ‘sine fulminans’. Clin Exp Dermatol. 2000;25:299–301.

    Article  CAS  PubMed  Google Scholar 

  18. Karvonen SL. Acne fulminans: report of clinical findings and treatment of twenty-four patients. J Am Acad Dermatol. 1993;28:572–9.

    Article  CAS  PubMed  Google Scholar 

  19. Placzek M, Degitz K, Schmidt H, et al. Acne fulminans in late-onset congenital adrenal hyperplasia. Lancet. 1999;354:739–40.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Andreas D. Katsambas .

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Katsambas, A.D., Dessinioti, C., Cunliffe, W.J. (2014). Clinical Aspects of Acne Fulminans. In: Zouboulis, C., Katsambas, A., Kligman, A. (eds) Pathogenesis and Treatment of Acne and Rosacea. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69375-8_29

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  • DOI: https://doi.org/10.1007/978-3-540-69375-8_29

  • Publisher Name: Springer, Berlin, Heidelberg

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