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Pathophysiology Overview

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Vitiligo

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References

  1. Bondanza S, Maurelli R, Paterna P et al (2007) Keratinocyte cultures from involved skin in vitiligo patients show an impaired in vitro behaviour. Pigment Cell Res 20:288–300

    Article  PubMed  CAS  Google Scholar 

  2. Cario-André M, Pain C, Gauthier Y et al (2006) In vivo and in vitro evidence of dermal fibroblasts influence on human epidermal pigmentation. Pigment Cell Res 19:434–442

    Article  PubMed  Google Scholar 

  3. Dell'Anna ML, Maresca V, Briganti S et al (2001) Mitochondrial impairment in peripheral blood mononuclear cells during the active phase of vitiligo. J Invest Dermatol 117:908–913

    Article  PubMed  Google Scholar 

  4. Dell'Anna ML, Picardo M (2006) A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. Pigment Cell Res 19:406–411

    Article  PubMed  Google Scholar 

  5. Dell'Anna ML, Ottaviani M, Albanesi V et al (2007) Membrane lipid alterations as a possible basis for melano-cyte degeneration in vitiligo. J Invest Dermatol 127(5): 1226–1233

    Article  PubMed  Google Scholar 

  6. Denman CJ, McCracken J, Hariharan V et al (2008) HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. J Invest Dermatol 128:2041–2048

    Article  PubMed  CAS  Google Scholar 

  7. Erf GF, Trovillion CT, Plumlee BL et al (2008) Smyth line chicken model for autoimmune vitiligo: opportunity to examine events leading to the expression of vitiligo in susceptible individuals. Pigment Cell Res 21:265

    Google Scholar 

  8. Giovannelli L, Bellandi S, Pitozzi V et al (2004) Increased oxidative DNA damage in mononuclear leukocytes in viti-ligo. Mut Res 556:101–106

    Article  CAS  Google Scholar 

  9. Imokawa G (2004) Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res 17:96–110

    Article  PubMed  CAS  Google Scholar 

  10. Kim NH, Jeon S, Lee HJ et al (2007) Impaired PI3K/Akt activation-mediated NF-kB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes. J Invest Dermatol 127:2612–2617

    Article  PubMed  CAS  Google Scholar 

  11. Kim YC, Kim YJ, Kang HY et al (2008) Histopathologic features in vitiligo. Am J Dermatopathol 30:112–116

    Article  PubMed  Google Scholar 

  12. Kroll TM, Bommiasamy H, Boissy RE et al (2005) 4- tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. J Invest Dermatol 124:798–806

    Article  PubMed  CAS  Google Scholar 

  13. Lee YA, Kim NH, Choi WI et al (2005) Less keratinocyte-derived factors related to more keratinocyte apoptosis in depigmented than normally pigmented suction-blistered epidermis may cause passive melanocyte death in vitiligo. J Invest Dermatol 124:976–983

    Article  PubMed  CAS  Google Scholar 

  14. Le Poole IC, Das PK, van den Wijngaard RM et al (1993) Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 2:145–153

    Article  PubMed  Google Scholar 

  15. Le Poole IC, Wankowicz-Kalinska A, van den Wijngaard RM et al (2004) Autoimmune aspects of depigmentation in vitiligo. J Invest Dermatol Symp Proc 9:68–72

    Article  Google Scholar 

  16. Moretti S, Spallanzani A, Amato L et al (2002) New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 15:87–92

    Article  PubMed  CAS  Google Scholar 

  17. Pelle E, Mammone T, Maes D et al (2005) Keratinocytes as a source of reactive oxygen species by transferring hydrogen peroxide to melanocytes. J Invest Dermatol 124:793–797

    Article  PubMed  CAS  Google Scholar 

  18. Schallreuter KU, Bahadoran P, Picardo M et al (2008) Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcuim imbalance, or what else. Exp Dermatol 17:139–160

    PubMed  CAS  Google Scholar 

  19. Spritz RA (2006) The genetics of generalized vitiligo and associated autoimmune diseases. J Dermatol Sci 41:3–10

    Article  PubMed  CAS  Google Scholar 

  20. Taieb A (2000) Intrinsic and extrinsic pathomechanisms in vitiligo. Pigment Cell Res 13:41–47

    Article  PubMed  Google Scholar 

  21. Taieb A, Morice-Picard F, Jouary T et al (2008) Segmental vitiligo as the possibile expression of cutaneous somatic mosaicism: implications for common non-segmental viti-ligo. Pigment Cell Mel Res 21:646–652

    Article  Google Scholar 

  22. van den Wijngaard RM, Aten J, Scheepmaker A et al (2000) Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo. Br J Dermatol 143:573–581

    Article  PubMed  Google Scholar 

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Picardo, M., Taïeb, A. (2010). Pathophysiology Overview. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69361-1_21

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  • DOI: https://doi.org/10.1007/978-3-540-69361-1_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69360-4

  • Online ISBN: 978-3-540-69361-1

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