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Anti-angiogenic properties of Chemopreventive Drugs: Fenretinide as a Prototype.

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Cancer Prevention II

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 181))

Abstract

Several cancer chemopreventive agents have been demonstrated to exert antian-giogenic effects. Blocking tumor angio genesis, a process critical for tumor mass expansion and metastasis, represents an intriguing approach not only to cancer therapy, but also to cancer chemo prevention. We found that angiogenesis is a common and key target of many chemo-preventive molecules, where they most likely suppress the angiogenic switch in premalignant tumors, a concept we termed “angioprevention.” In this manuscript we use as an example the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR), a molecule with confirmed clinical applications in breast cancer adjuvant therapy to prevent cancer recurrence and under evaluation in neuro blastoma and glioblastoma treatment.

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Authors and Affiliations

  1. IRCCS MultiMedica Oncology Research, Via Fantoli 16/15, Milan, 20138, Italy

    Ilaria Sogno & Adriana Albini

  2. Molecular Oncology and Angiogenesis Laboratory, National Cancer Research Institute (IST), Largo R. Benzi, 10, Genoa, 16132, Italy

    Roberta Venè, Cristina Sapienza, Nicoletta Ferrari & Francesca Tosetti

Authors
  1. Ilaria Sogno
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  2. Roberta Venè
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  3. Cristina Sapienza
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  4. Nicoletta Ferrari
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  5. Francesca Tosetti
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  6. Adriana Albini
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Corresponding author

Correspondence to Adriana Albini .

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Editors and Affiliations

  1. Zentrum fücr Tumordiagnostik und Prävention, Rorschacherstr. 150, St. Gallen, 9006, Schweiz

    Hans-Jörg Senn , Ursula Kapp  & Florian Otto ,  & 

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© 2009 Springer-Verlag Berlin Heidelberg

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Sogno, I., Venè, R., Sapienza, C., Ferrari, N., Tosetti, F., Albini, A. (2009). Anti-angiogenic properties of Chemopreventive Drugs: Fenretinide as a Prototype.. In: Senn, HJ., Kapp, U., Otto, F. (eds) Cancer Prevention II. Recent Results in Cancer Research, vol 181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69297-3_8

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  • DOI: https://doi.org/10.1007/978-3-540-69297-3_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69296-6

  • Online ISBN: 978-3-540-69297-3

  • eBook Packages: MedicineMedicine (R0)

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