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Aspirin and Cancer Risk: A Summary Review to 2007

  • Conference paper
Cancer Prevention II

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 181))

Abstract

With few exceptions, epidemiological studies have found that individuals who take nonsteroidal antiinflammatory drugs (NSAIDs) have a reduced risk of colorectal adenomas and carcinoma. Similarly, randomized studies in patients with familial adenomatous polyposis have uniformly found that NSAIDs can lead to polyp regression and prevention of new polyps, and trials in patients with sporadic adenomas document that aspirin reduces the risk of adenoma recurrence. Together these data provide convincing evidence for the chemopreventive efficacy of NSAIDs in the large bowel.

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References

  • Akhmedkhanov A, Toniolo P, Zeleniuch-Jacquotte A, Kato I, Koenig KL, Shore RE (2001) Aspirin and epithelial ovarian cancer. Prev Med 33:682–687

    Article  PubMed  CAS  Google Scholar 

  • Akhmedkhanov A, Toniolo P, Zeleniuch-Jacquotte A, Koenig KL, Shore RE (2002) Aspirin and lung cancer in women. Br J Cancer 87:49–53

    Article  PubMed  CAS  Google Scholar 

  • Akre K, Ekstrom AM, Signorello LB, Hansson LE,Nyren O (2001) Aspirin and risk for gastric cancer: a population-based case-control study in Sweden. Br J Cancer 84:965–968

    Article  PubMed  CAS  Google Scholar 

  • Allison M, Garland C, Chlebowski R, Criqui M, Langer R, Wu L, Roy H, McTiernan A, Kuller L (2006) The association between aspirin use and the incidence of colorectal cancer in women. Am J Epidemiol 164:567–575

    Article  PubMed  Google Scholar 

  • Anderson KE, Johnson TW, Lazovich D, Folsom AR (2002) Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer. J Natl Cancer Inst 94:1168–1171

    PubMed  Google Scholar 

  • Asano TK, McLeod RS (2004) Nonsteroidal anti-inflammatory drugs and aspirin for the prevention of colorectal adenomas and cancer: a systematic review. Dis Colon Rectum 47:665–673

    Article  PubMed  CAS  Google Scholar 

  • Baker JA, Weiss JR, Czuczman MS, Menezes RJ, Ambrosone CB, Moysich KB (2005) Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma. Cancer Causes Control 16:301–308

    Article  PubMed  Google Scholar 

  • Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?. Lancet 357:539–545

    Article  PubMed  CAS  Google Scholar 

  • Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, McKeown-Eyssen G, Summers RW, Rothstein R, Burke CA, et al (2003) A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med 348:891–899

    Article  PubMed  CAS  Google Scholar 

  • Benamouzig R, Deyra J, Martin A, Girard B, Jullian E, Piednoir B, Couturier D, Coste T, Little J, Chaussade S (2003) Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology 125:328–336

    Article  PubMed  CAS  Google Scholar 

  • Berkel H, Holcombe RF, Middlebrooks M, Kannan K (1996) Nonsteroidal antiinflammatory drugs and colorectal cancer. Epidemiol Rev 18:205–217

    PubMed  CAS  Google Scholar 

  • Bernstein L, Ross RK (1992) Prior medication use and health history as risk factors for non-Hodg-kin's lymphoma: preliminary results from a case-control study in Los Angeles County. Cancer Res 52:5510s–5515 s

    PubMed  CAS  Google Scholar 

  • Bosetti C, Gallus S, La Vecchia C (2002) Aspirin and cancer risk: an update to 2001. Eur J Cancer Prev 11:535–542

    Article  PubMed  CAS  Google Scholar 

  • Bosetti C, Gallus S, La Vecchia C (2006a) Aspirin and cancer risk: an updated quantitative review to 2005. Cancer Causes Control 17:871–888

    Article  Google Scholar 

  • Bosetti C, Talamini R, Negri E, Franceschi S, Montella M, La Vecchia C (2006b) Aspirin and the risk of prostate cancer. Eur J Cancer Prev 15:43–45

    Article  CAS  Google Scholar 

  • Castelao JE, Yuan JM, Gago-Dominguez M, Yu MC, Ross RK (2000) Non-steroidal anti-inflamma tory drugs and bladder cancer prevention. Br J Cancer 82:1364–1369

    Article  PubMed  CAS  Google Scholar 

  • Cerhan JR, Anderson KE, Janney CA, Vachon CM, Witzig TE, Habermann TM (2003) Association of aspirin and other non-steroidal anti-inflammatory drug use with incidence of non-Hodgkin lymphoma. Int J Cancer 106:784–788

    Article  PubMed  CAS  Google Scholar 

  • Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC, Fuchs CS (2005) Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA 294:914–923

    Article  PubMed  CAS  Google Scholar 

  • Chang ET, Zheng T, Weir EG, Borowitz M, Mann RB, Spiegelman D, Mueller NE (2004) Aspirin and the risk of Hodgkin's lymphoma in a population-based case-control study. J Natl Cancer Inst 96:305–315

    PubMed  CAS  Google Scholar 

  • Coogan PF, Rao SR, Rosenberg L, Palmer JR, Strom BL, Zauber AG, Stolley PD, Shapiro S (1999) The relationship of nonsteroidal anti-inflammatory drug use to the risk of breast cancer. Prev Med 29:72–76

    Article  PubMed  CAS  Google Scholar 

  • Cook NR, Lee IM, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE (2005) Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 294:47–55

    Article  PubMed  CAS  Google Scholar 

  • Corley DA, Kerlikowske K, Verma R, Buffler P (2003) Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology 124:47–56

    Article  PubMed  CAS  Google Scholar 

  • Cotterchio M, Kreiger N, Sloan M, Steingart A (2001) Nonsteroidal anti-inflammatory drug use and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10:1213–1217

    PubMed  CAS  Google Scholar 

  • Cramer DW, Harlow BL, Titus-Ernstoff L, Bohlke K, Welch WR, Greenberg ER (1998) Over-the-counter analgesics and risk of ovarian cancer.Lancet 351:104–107

    Article  PubMed  CAS  Google Scholar 

  • Egan KM, Stampfer MJ, Giovannucci E, Rosner BA, Colditz GA (1996) Prospective study of regular aspirin use and the risk of breast cancer. J Natl Cancer Inst 88:988–993

    Article  PubMed  CAS  Google Scholar 

  • Fairfield KM, Hunter DJ, Fuchs CS, Colditz GA, Hankinson SE (2002) Aspirin, other NSAIDs, and ovarian cancer risk (United States). Cancer Causes Control 13:535–542

    Article  PubMed  Google Scholar 

  • Farrow DC, Vaughan TL, Hansten PD, Stanford JL, Risch HA, Gammon MD, Chow WH, Dubrow R, Ahsan H, Mayne ST, et al (1998) Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 7:97–102

    PubMed  CAS  Google Scholar 

  • Feskanich D, Bain C, Chan AT, Pandeya N, Speizer FE, Colditz GA (2007) Aspirin and lung cancer risk in a cohort study of women: dosage, duration and latency. Br J Cancer 97:1295–1299

    Article  PubMed  CAS  Google Scholar 

  • Fiorucci S, Antonelli E (2001) Cyclo-oxygenase isoenzymes. Structural basis for selective inhibition of cyclo-oxygenases by anti-inflammatory agents. Dig Liver Dis 33[Suppl 2]:S2–S7

    CAS  Google Scholar 

  • Flick ED, Chan KA, Bracci PM, Holly EA (2006) Use of nonsteroidal antiinflammatory drugs and non-Hodgkin lymphoma: a population-based case-control study. Am J Epidemiol 164:497–504

    Article  PubMed  Google Scholar 

  • Fortuny J, Kogevinas M, Zens MS, Schned A, Andrew AS, Heaney J, Kelsey KT, Karagas MR (2007) Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study. BMC Urol 7:13

    Article  PubMed  CAS  Google Scholar 

  • Friedman GD, Ury HK (1980) Initial screening for carcinogenicity of commonly used drugs. J Natl Cancer Inst 65:723–733

    PubMed  CAS  Google Scholar 

  • Friedman GD, Coates AO, Potter JD, Slattery ML (1998) Drugs and colon cancer. Pharmacoepidemiol Drug Saf 7:99–106

    Article  PubMed  CAS  Google Scholar 

  • Friis S, Sorensen HT, McLaughlin JK, Johnsen S P, Blot WJ, Olsen JH (2003) A population-based cohort study of the risk of colorectal and other cancers among users of low-dose aspirin. Br J Cancer 88:684–688

    Article  PubMed  CAS  Google Scholar 

  • Funkhouser EM, Sharp GB (1995) Aspirin and reduced risk of esophageal carcinoma. Cancer 76:1116–1119

    Article  PubMed  CAS  Google Scholar 

  • Gago-Dominguez M, Yuan JM, Castelao JE, Ross RK, Yu MC (1999) Regular use of analgesics is a risk factor for renal cell carcinoma. Br J Cancer 81:542–548

    Article  PubMed  CAS  Google Scholar 

  • Gann PH, Manson JE, Glynn RJ, Buring JE, Hennekens CH (1993) Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J Natl Cancer Inst 85:1220–1224

    Article  PubMed  CAS  Google Scholar 

  • García Rodríguez LA, González-Pérez A (2004a) Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer. Cancer Epidemiol Biomarkers Prev 13:649–653

    Google Scholar 

  • García-Rodríguez LA, González-Pérez A (2004b) Risk of breast cancer among users of aspirin and other anti-inflammatory drugs. Br J Cancer 91:525–529

    Article  CAS  Google Scholar 

  • García-Rodríguez LA, Huerta-Alvarez C (2001) Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs. Epidemiology 12:88–93

    Article  PubMed  Google Scholar 

  • Genkinger JM, De Vivo I, Stampfer MJ, Giovannucci E, Michaud DS (2007) Nonsteroidal antiinflam-matory drug use and risk of bladder cancer in the health professionals follow-up study. Int J Cancer 120:2221–2225

    Article  PubMed  CAS  Google Scholar 

  • Gill JK, Maskarinec G, Wilkens LR, Pike MC, Henderson BE, Kolonel LN (2007) Nonsteroidal antiinflammatory drugs and breast cancer risk: the multiethnic cohort. Am J Epidemiol 166:1150–1158

    Article  PubMed  Google Scholar 

  • Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC (1994) Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121:241–246

    PubMed  CAS  Google Scholar 

  • Giovannucci E, Egan KM, Hunter DJ, Stampfer MJ, Colditz GA, Willett WC, Speizer FE (1995) Aspirin and the risk of colorectal cancer in women. N Engl J Med 333:609–614

    Article  PubMed  CAS  Google Scholar 

  • Greenberg ER, Baron JA (1996) Aspirin and other nonsteroidal anti-inflammatory drugs as cancer-preventive agents. In: Stewart B W, McGregor D, Kleihies P (eds) Principles of chemoprevention.IARC Scientific Publications, Lyon

    Google Scholar 

  • Greenberg ER, Baron JA, Freeman DH Jr, Mandel JS, Haile R (1993) Reduced risk of large-bowel adenomas among aspirin users. The Polyp Prevention Study Group. J Natl Cancer Inst 85:912–916

    Article  PubMed  CAS  Google Scholar 

  • Habel LA, Zhao W, Stanford JL (2002) Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US. Cancer Causes Control 13:427–434

    Article  PubMed  Google Scholar 

  • Harris RE, Namboodiri KK, Farrar WB (1996) Nonsteroidal antiinflammatory drugs and breast cancer. Epidemiology 7:203–205

    Article  PubMed  CAS  Google Scholar 

  • Harris RE, Kasbari S, Farrar WB (1999) Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer. Oncol Rep 6:71–73

    PubMed  CAS  Google Scholar 

  • Harris RE, Chlebowski RT, Jackson RD, et al (2003) Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. Cancer Res 63:6096–6101

    PubMed  CAS  Google Scholar 

  • Hayes JH, Anderson KE, Folsom AR (2006) Association between nonsteroidal anti-inflammatory drug use and the incidence of lung cancer in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev 15:2226–2231

    Article  PubMed  CAS  Google Scholar 

  • Herendeen JM, Lindley C (2003) Use of NSAIDs for the chemoprevention of colorectal cancer.Ann Pharmacother 37:1664–1674

    Article  PubMed  CAS  Google Scholar 

  • Hernández-Díaz S, García Rodríguez LA (2007) Nonsteroidal anti-inflammatory drugs and risk of lung cancer. Int J Cancer 120:1565–1572

    Article  PubMed  CAS  Google Scholar 

  • Holick CN, Michaud DS, Leitzmann MF, Willett WC, Giovannucci E (2003) Aspirin use and lung cancer in men. Br J Cancer 89:1705–1708

    Article  PubMed  CAS  Google Scholar 

  • IARC (1997) Non-steroidal anti-inflammatory drugs, vol 1. In: Handbooks of cancer prevention.International Agency for Research on Cancer, Lyon Irani J, Ravery V, Pariente JL, Chartier-Kastler E, Lechevallier E, Soulie M, Chautard D, Coloby P, Fontaine E, Bladou F, et al (2002) Effect of nons-teroidal anti-inflammatory agents and finasteride on prostate cancer risk. J Urol 168:1985–1988

    Google Scholar 

  • Jacobs EJ, Connell CJ, Rodriguez C, Patel AV, Calle EE, Thun MJ (2004) Aspirin use and pancreatic cancer mortality in a large United States cohort. J Natl Cancer Inst 96:524–528

    PubMed  CAS  Google Scholar 

  • Jacobs EJ, Rodriguez C, Mondul AM, Connell CJ, Henley SJ, Calle EE, Thun MJ (2005a) A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J Natl Cancer Inst 97:975–980

    Google Scholar 

  • Jacobs EJ, Thun MJ, Connell CJ, Rodriguez C, Henley SJ, Feigelson HS, Patel AV, Flanders WD, Calle EE (2005b) Aspirin and other nonsteroidal anti-inflammatory drugs and breast cancer incidence in a large U. S. cohort. Cancer Epidemiol Biomarkers Prev 14:261–264

    Article  CAS  Google Scholar 

  • Jacobs EJ, Thun MJ, Bain EB, Rodriguez C, Henley SJ, Calle EE (2007) A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. J Natl Cancer Inst 99:608–615

    Article  PubMed  CAS  Google Scholar 

  • Jayaprakash V, Menezes RJ, Javle MM, McCann SE, Baker JA, Reid ME, Natarajan N, Moysich KB (2006) Regular aspirin use and esophageal cancer risk. Int J Cancer 119:202–207

    Article  PubMed  CAS  Google Scholar 

  • Johnson T W, Anderson KE, Lazovich D, Folsom AR (2002) Association of aspirin and nonsteroidal anti-inflammatory drug use with breast cancer. Cancer Epidemiol Biomarkers Prev 11:1586–1591

    PubMed  CAS  Google Scholar 

  • Juarranz M, Calle-Purón ME, González-Navarro A, Regidor-Poyatos E, Soriano T, Martínez-Hernandez D, Rojas VD, Guinee VF (2002) Physical exercise, use of Plantago ovata and aspirin, and reduced risk of colon cancer. Eur J Cancer Prev 11:465–472

    Article  PubMed  CAS  Google Scholar 

  • Kasum CM, Blair CK, Folsom AR, Ross JA (2003) Non-steroidal anti-inflammatory drug use and risk of adult leukemia. Cancer Epidemiol Biomarkers Prev 12:534–537

    PubMed  CAS  Google Scholar 

  • Kato I, Koenig KL, Shore RE, Baptiste MS, Lillquist P P, Frizzera G, Burke JS, Watanabe H (2002) Use of anti-inflammatory and non-narcotic analgesic drugs and risk of non-Hodgkin's lymphoma (NHL) (United States). Cancer Causes Control 13:965–974

    Article  PubMed  Google Scholar 

  • Kelly J P, Coogan P, Strom BL, Rosenberg L (2007) Lung cancer and regular use of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs. Pharmacoepidemiol Drug Saf 17:322–327

    Article  Google Scholar 

  • Kune GA, Kune S, Watson LF (1988) Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res 48:4399–4404

    PubMed  CAS  Google Scholar 

  • La Vecchia C, Negri E, Franceschi S, Conti E, Montella M, Giacosa A, Falcini A, Decarli A (1997) Aspirin and colorectal cancer. Br J Cancer 76:675–677

    PubMed  CAS  Google Scholar 

  • Lacey JV Jr, Sherman ME, Hartge P, Schatzkin A, Schairer C (2004) Medication use and risk of ovarian carcinoma: a prospective study. Int J Cancer 108:281–286

    Article  PubMed  CAS  Google Scholar 

  • Larsson SC, Giovannucci E, Wolk A (2006) Long-term aspirin use and colorectal cancer risk:a cohort study in Sweden. Br J Cancer 95:1277–1279

    Article  PubMed  CAS  Google Scholar 

  • Leitzmann MF, Stampfer MJ, Ma J, Chan JM, Colditz GA, Willett WC, Giovannucci E (2002) Aspirin use in relation to risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 11:1108–1111

    PubMed  CAS  Google Scholar 

  • Levi F, Lucchini F, Negri E, Boyle P, La Vecchia C (2004) Cancer mortality in Europe, 1995–1999, and an overview of trends since 1960. Int J Cancer 110:155–169

    Article  PubMed  CAS  Google Scholar 

  • Lindblad M, Lagergren J, García Rodríguez LA (2005) Nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 14:444–450

    Article  PubMed  CAS  Google Scholar 

  • Liu E, Sakoda LC, Gao YT, Rashid A, Shen MC, Wang BS, Deng J, Han TQ, Zhang BH, Fraumeni JF Jr, et al (2005) Aspirin use and risk of biliary tract cancer: a population-based study in Shanghai, China. Cancer Epidemiol Biomarkers Prev 14:1315–1318

    Article  PubMed  CAS  Google Scholar 

  • Mahipal A, Anderson KE, Limburg PJ, Folsom AR (2006) Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev 15:1785–1790

    Article  PubMed  CAS  Google Scholar 

  • Marshall SF, Bernstein L, Anton-Culver H, Deapen D, Horn-Ross PL, Mohrenweiser H, Peel D, Pinder R, Purdie DM, Reynolds P, et al (2005) Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status. J Natl Cancer Inst 97:805–812

    PubMed  CAS  Google Scholar 

  • McCredie M, Ford JM, Stewart JH (1988) Risk factors for cancer of the renal parenchyma. Int J Cancer 42:13–16

    Article  PubMed  CAS  Google Scholar 

  • McCredie M, Pommer W, McLaughlin JK, Stewart JH, Lindblad P, Mandel JS, Mellemgaard A, Schlehofer B, Niwa S (1995) International renal-cell cancer study. II. Analgesics. Int J Cancer 60:345–349

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin JK, Blot WJ, Mehl ES, Fraumeni JF Jr (1985) Relation of analgesic use to renal cancer: population-based findings. Natl Cancer Inst Monogr 69:217–222

    PubMed  CAS  Google Scholar 

  • Mellemgaard A, Niwa S, Mehl ES, Engholm G, McLaughlin JK, Olsen JH (1994) Risk factors for renal cell carcinoma in Denmark: role of medication and medical history. Int J Epidemiol 23:923–930

    Article  PubMed  CAS  Google Scholar 

  • Menezes RJ, Swede H, Mettlin C, Moysich KB (2002a) Regular aspirin use and risk of prostate cancer. In: Proceedings of the American Association for Cancer Research Annual Meeting, San Francisco, vol 43:933

    Google Scholar 

  • Menezes RJ, Huber KR, Mahoney MC, Moysich KB (2002b) Regular use of aspirin and pancreatic cancer risk. BMC Public Health 2:18

    Article  Google Scholar 

  • Menezes RJ, Swede H, Niles R, Moysich KB (2006) Regular use of aspirin and prostate cancer risk (United States). Cancer Causes Control 17:251–256

    Article  PubMed  Google Scholar 

  • Moysich KB, Mettlin C, Piver MS, Natarajan N, Menezes RJ, Swede H (2001) Regular use of analgesic drugs and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev 10:903–906

    PubMed  CAS  Google Scholar 

  • Moysich KB, Menezes RJ, Ronsani A, Swede H, Reid ME, Cummings KM, Falkner KL, Loewen GM, Bepler G (2002) Regular aspirin use and lung cancer risk. BMC Cancer 2:31

    Article  PubMed  Google Scholar 

  • Moysich KB, Baker JA, Rodabaugh KJ, Villella JA (2005) Regular analgesic use and risk of endome-trial cancer. Cancer Epidemiol Biomarkers Prev 14:2923–2928

    Article  PubMed  CAS  Google Scholar 

  • Moysich KB, Bonner MR, Beehler G P, Marshall JR, Menezes RJ, Baker JA, Weiss JR, Chanan-Khan A (2007) Regular analgesic use and risk of multiple myeloma. Leuk Res 31:547–551

    Article  PubMed  CAS  Google Scholar 

  • Muscat JE, Stellman SD, Wynder EL (1994) Nonsteroidal antiinflammatory drugs and color-ectal cancer. Cancer 74:1847–1854

    Article  PubMed  CAS  Google Scholar 

  • Muscat JE, Chen SQ, Richie JP Jr, Altorki NK, Citron M, Olson S, Neugut AI, Stellman SD (2003) Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. Cancer 97:1732–1736

    Article  PubMed  Google Scholar 

  • Ness RB, Cottreau C (1999) Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst 91:1459–1467

    Article  PubMed  CAS  Google Scholar 

  • Neugut AI, Rosenberg DJ, Ahsan H, Jacobson JS, Wahid N, Hagan M, Rahman MI, Khan ZR, Chen L, Pablos-Mendez A, et al (1998) Association between coronary heart disease and cancers of the breast, prostate, and colon. Cancer Epidemiol Biomarkers Prev 7:869–873

    PubMed  CAS  Google Scholar 

  • Norrish AE, Jackson RT, McRae CU (1998) Non-steroidal anti-inflammatory drugs and prostate cancer progression. Int J Cancer 77:511–515

    Article  PubMed  CAS  Google Scholar 

  • Olsen JH, Friis S, Poulsen AH, Fryzek J, Harving H, Tjonneland A, Sorensen HT, Blot W (2008) Use of NSAIDs, smoking and lung cancer risk. Br J Cancer 98:232–237

    Article  PubMed  CAS  Google Scholar 

  • Paganini-Hill A, Chao A, Ross RK, Henderson BE (1989) Aspirin use and chronic diseases: a cohort study of the elderly. BMJ 299:1247–1250

    Article  PubMed  CAS  Google Scholar 

  • Peleg II, Maibach HT, Brown SH, Wilcox CM (1994) Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Arch Intern Med 154:394–399

    Article  PubMed  CAS  Google Scholar 

  • Perron L, Bairati I, Moore L, Meyer F (2003) Dosage, duration and timing of nonsteroidal antiinflammatory drug use and risk of prostate cancer. Int J Cancer 106:409–415

    Article  PubMed  CAS  Google Scholar 

  • Platz EA, Rohrmann S, Pearson JD, Corrada MM, Watson DJ, De Marzo AM, Landis PK, Metter EJ, Carter HB (2005) Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. Cancer Epidemiol Biomarkers Prev 14:390–396

    Article  PubMed  CAS  Google Scholar 

  • Ratnasinghe LD, Graubard BI, Kahle L, Tangrea JA, Taylor PR, Hawk E (2004) Aspirin use and mortality from cancer in a prospective cohort study. Anticancer Res 24:3177–3184

    PubMed  Google Scholar 

  • Reeves MJ, Newcomb PA, Trentham-Dietz A, Storer BE, Remington PL (1996) Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 5:955–960

    PubMed  CAS  Google Scholar 

  • Rosenberg L, Palmer JR, Zauber AG, Warshauer ME, Stolley PD, Shapiro S (1991) A hypothesis:nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst 83:355–358

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg L, Louik C, Shapiro S (1998) Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma. Cancer 82:2326–2333

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg L, Palmer JR, Rao RS, Coogan PF, Strom BL, Zauber AG, Stolley PD, Shapiro S (2000) A case-control study of analgesic use and ovarian cancer. Cancer Epidemiol Biomarkers Prev 9:933–937

    PubMed  CAS  Google Scholar 

  • Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, Petrelli N, Pipas JM, Karp DD, Loprinzi CL, et al (2003) A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med 348:883–890

    Article  PubMed  CAS  Google Scholar 

  • Sansbury LB, Millikan RC, Schroeder JC, Moorman PG, North KE, Sandler RS (2005) Use of nons-teroidal antiinflammatory drugs and risk of colon cancer in a population-based, case-control study of African Americans and Whites. Am J Epidemiol 162:548–558

    Article  PubMed  Google Scholar 

  • Schernhammer ES, Kang JH, Chan AT, Michaud DS, Skinner HG, Giovannucci E, Colditz GA, Fuchs CS (2004) A prospective study of aspirin use and the risk of pancreatic cancer in women. J Natl Cancer Inst 96:22–28

    Article  PubMed  CAS  Google Scholar 

  • Schildkraut JM, Moorman PG, Halabi S, Calingaert B, Marks JR, Berchuck A (2006) Analgesic drug use and risk of ovarian cancer. Epidemiology 17:104–107

    Article  PubMed  Google Scholar 

  • Schreinemachers DM, Everson RB (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5:138–146

    Article  PubMed  CAS  Google Scholar 

  • Sharp L, Chilvers CE, Cheng KK, McKinney PA, Logan RF, Cook-Mozaffari P, Ahmed A, Day NE (2001) Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study. Br J Cancer 85:1667–1670

    Article  PubMed  CAS  Google Scholar 

  • Signorello LB, McLaughlin JK, Lipworth L, Friis S, Sorensen HT, Blot WJ (2003) Confounding by indication: implications for implant research. J Long Term Eff Med Implants 13:63–68

    Article  PubMed  Google Scholar 

  • Sturmer T, Glynn RJ, Lee IM, Manson JE, Buring JE, Hennekens CH (1998) Aspirin use and colorectal cancer: post-trial follow-up data from the Physicians' Health Study. Ann Intern Med 128:713–720

    PubMed  CAS  Google Scholar 

  • Suh O, Mettlin C, Petrelli NJ (1993) Aspirin use, cancer, and polyps of the large bowel. Cancer 72:1171–1177

    Article  PubMed  CAS  Google Scholar 

  • Swede H, Mirand AL, Menezes RJ, Moysich KB (2005) Association of regular aspirin use and breast cancer risk. Oncology 68:40–47

    Article  PubMed  CAS  Google Scholar 

  • Taketo MM (1998a) Cyclooxygenase-2 inhibitors in tumorigenesis (part I). J Natl Cancer Inst 90:1529–1536

    Article  CAS  Google Scholar 

  • Taketo MM (1998b) Cyclooxygenase-2 inhibitors in tumorigenesis (Part II). J Natl Cancer Inst 90:1609–1620

    Article  CAS  Google Scholar 

  • Tavani A, Gallus S, La Vecchia C, Conti E, Montella M, Franceschi S (2000) Aspirin and ovarian cancer: an Italian case-control study. Ann Oncol 11:1171–1173

    Article  PubMed  CAS  Google Scholar 

  • Terry MB, Gammon MD, Zhang FF, Tawfik H, Teitelbaum SL, Britton JA, Subbaramaiah K, Dannenberg AJ, Neugut AI (2004) Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA 291:2433–2440

    Article  PubMed  CAS  Google Scholar 

  • Thun MJ, Namboodiri MM, Heath CW Jr (1991) Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 325:1593–1596

    PubMed  CAS  Google Scholar 

  • Thun MJ, Namboodiri MM, Calle EE, Flanders WD, Heath CW Jr (1993) Aspirin use and risk of fatal cancer. Cancer Res 53:1322–1327

    PubMed  CAS  Google Scholar 

  • Thun MJ, Henley SJ, Patrono C (2002) Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 94:252–266

    PubMed  CAS  Google Scholar 

  • Tzonou A, Polychronopoulou A, Hsieh CC, Rebelakos A, Karakatsani A, Trichopoulos D (1993) Hair dyes, analgesics, tranquilizers and perineal talc application as risk factors for ovarian cancer. Int J Cancer 55:408–410

    Article  PubMed  CAS  Google Scholar 

  • Vinogradova Y, Hippisley-Cox J, Coupland C, Logan RF (2007) Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study. Gastroenterology 133:393–402

    Article  PubMed  Google Scholar 

  • Wang WH, Huang JQ, Zheng GF, Lam SK, Karlberg J, Wong BC (2003) Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. J Natl Cancer Inst 95:1784–1791

    PubMed  CAS  Google Scholar 

  • Zaridze D, Borisova E, Maximovitch D, Chkhikvadze V (1999) Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int J Cancer 82:473–476

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, Holford TR, Leaderer B, Zahm SH, Boyle P, Morton LM, Zhang B, Zou K, Flynn S, Tallini G, et al (2004) Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women. Cancer Causes Control 15:419–428

    Article  PubMed  Google Scholar 

  • Zhang Y, Coogan P F, Palmer JR, Strom BL, Rosenberg L (2005) Use of nonsteroidal antiin-flammatory drugs and risk of breast cancer: the Case-Control Surveillance Study revisited. Am J Epidemiol 162:165–170

    Article  PubMed  Google Scholar 

  • Zhang Y, Coogan PF, Palmer JR, Strom BL, Rosenberg L (2006) Risk of non-Hodgkin lym-phoma and use of non-steroidal anti-inflammatory drugs. Cancer Detect Prev 30:99–101References

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche, Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy

    Cristina Bosetti & Silvano Gallus

  2. Mario Negri Institute for Pharmacological Research, Laboratory of General Epidemiology, Via La Masa 19, 20156 Milan, Italy

    Carlo La Vecchia

Authors
  1. Cristina Bosetti
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  2. Silvano Gallus
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  3. Carlo La Vecchia
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Correspondence to Carlo La Vecchia .

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  1. Zentrum fücr Tumordiagnostik und Prävention, Rorschacherstr. 150, St. Gallen, 9006, Schweiz

    Hans-Jörg Senn , Ursula Kapp  & Florian Otto ,  & 

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Bosetti, C., Gallus, S., Vecchia, C.L. (2009). Aspirin and Cancer Risk: A Summary Review to 2007. In: Senn, HJ., Kapp, U., Otto, F. (eds) Cancer Prevention II. Recent Results in Cancer Research, vol 181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69297-3_22

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  • DOI: https://doi.org/10.1007/978-3-540-69297-3_22

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