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Prostate Cancer Prevention by Short-Term Anti-androgens: The Rationale Behind Design of Pilot Studies

  • Conference paper
Cancer Prevention II

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 181))

Abstract

This paper sets out to review evidence that low-grade prostate inflammation is a precursor of prostate cancer development and the mechanisms by which it may account for the more than 50 years natural history from first infection to cancer. Though as yet there is no clear-cut specific associated infection, there is clear evidence that some sexually acquired infections damage the prostate and increase serum PSA with slow recovery back to normal. The demonstration that low-level solar exposure is protective provides a possible mechanism due to vitamin D's known benefit through action to boost macrophage-mediated immune surveillance. This observation and data demonstrating that non-steroidal anti-inflammatory drugs (NSAIDs) protect against prostate cancer provide the justification for trials of these two agents combined with short course intermittent anti-androgen therapy in populations at high risk of prostate cancer.

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Authors and Affiliations

  1. Wolfson Institute of Preventive Medicine, EPN 2056 6130 Executive Blvd., P.O. Box 2040, Bethesda, MD 20852, USA

    Tim Oliver, Attila Lorincz & Jack Cuzick

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  1. Tim Oliver
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  2. Attila Lorincz
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  3. Jack Cuzick
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Correspondence to Tim Oliver .

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  1. Zentrum fücr Tumordiagnostik und Prävention, Rorschacherstr. 150, St. Gallen, 9006, Schweiz

    Hans-Jörg Senn , Ursula Kapp  & Florian Otto ,  & 

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Oliver, T., Lorincz, A., Cuzick, J. (2009). Prostate Cancer Prevention by Short-Term Anti-androgens: The Rationale Behind Design of Pilot Studies. In: Senn, HJ., Kapp, U., Otto, F. (eds) Cancer Prevention II. Recent Results in Cancer Research, vol 181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69297-3_18

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  • DOI: https://doi.org/10.1007/978-3-540-69297-3_18

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